{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:32:32Z","timestamp":1783524752659,"version":"3.55.0"},"reference-count":46,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2011,7,29]]},"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>A multicentre cohort follow-up study of a large number of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma was conducted to elucidate the long-term outcome of the disease after <jats:italic>Helicobacter pylori<\/jats:italic> eradication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>420 patients with gastric low-grade MALT lymphoma who had undergone successful <jats:italic>H pylori<\/jats:italic> eradication and been followed up for at least 3\u2005years were registered from 21 participating institutes. Responders to treatment were defined as patients whose post-treatment biopsies showed complete histological response (ChR) or probable minimal residual disease (pMRD). Treatment failure was defined as the status of progressive disease or lymphoma relapse after ChR\/pMRD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>323 patients (77%) responded to <jats:italic>H pylori<\/jats:italic> eradication. A logistic regression analysis showed that absence of <jats:italic>H pylori<\/jats:italic>, submucosal invasion determined by endoscopic ultrasonography and t(11;18)\/<jats:italic>API2-MALT1<\/jats:italic> were independent predictors of resistance to <jats:italic>H pylori<\/jats:italic> eradication. During the follow-up periods ranging from 3.0 to 14.6\u2005years (mean 6.5\u2005years, median 6.04\u2005years), the disease relapsed in 10 of 323 responders (3.1%) while progressive disease was found in 27 of 97 non-responders (27%). Thus, 37 of 420 patients (8.8%) were regarded as treatment failures. Of these 37 patients, transformation into diffuse large B cell lymphoma occurred in nine patients. Among the non-responders and relapsed patients, 17 patients were subjected to a \u2018watch and wait\u2019 strategy while 90 patients underwent second-line treatments including radiotherapy (n=49), chemotherapy (n=26), surgical resection (n=6), chemoradiotherapy (n=5), antibiotic treatment (n=2), rituximab monotherapy (n=1) or endoscopic resection (n=1). Probabilities of freedom from treatment failure, overall survival and event-free survival after 10\u2005years were 90%, 95% and 86%, respectively. Cox multivariate analysis revealed endoscopic non-superficial type to be an independent prognostic factor for adverse freedom from treatment failure, overall survival and event-free survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The excellent long-term outcome of gastric MALT lymphoma after <jats:italic>H pylori<\/jats:italic> eradication was confirmed by this large-scale follow-up study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gutjnl-2011-300495","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T00:41:07Z","timestamp":1315010467000},"page":"507-513","source":"Crossref","is-referenced-by-count":260,"title":["Long-term clinical outcome of gastric MALT lymphoma after eradication of <i>Helicobacter pylori<\/i>: a multicentre cohort follow-up study of 420 patients in Japan"],"prefix":"10.1136","volume":"61","author":[{"given":"Shotaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tajika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanobu","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Kamoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Origasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the JAPAN GAST Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"2025090712561569000_61.4.507.1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1703"},{"key":"2025090712561569000_61.4.507.2","unstructured":"Isaacson PG Chott A Nakamura S . 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