{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:43:34Z","timestamp":1791179014937,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2012,3,4]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Serrated (hyperplastic) polyposis (SP) is a rare disorder with multiple colorectal hyperplastic polyps and often sessile serrated adenomas\/polyps (SSA\/P) or adenomas. Although associated with colorectal cancer, the course of SP is not well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>44 patients with SP were studied. The results of 146 colonoscopies with median follow-up of 2.0\u2005years (range 0\u201330) and a median of 1.0\u2005years (range 0.5\u20136) between surveillance colonoscopies were evaluated. Findings from oesophogastroduodenoscopy examinations were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age at diagnosis of SP was 52.5\u00b111.9\u2005years (range 22\u201378). In two pedigrees (5%) another family member had SP. None of 22 patients had gastroduodenal polyps. All patients had additional colorectal polyps at surveillance colonoscopy. SSA\/P or adenomas were found in 25 patients (61%) at first colonoscopy and 83% at last colonoscopy. Recurrent SSA\/P or adenomas occurred in 68% of patients at surveillance colonoscopy. Three patients had colorectal cancer. Eleven patients (25%) underwent surgery (mean time from diagnosis of SP 2.0\u00b10.9\u2005years). After surgery all seven surveyed patients developed recurrent polyps in the retained colorectum (4\/7 had SSA\/P or adenomas). No association was found between colorectal neoplasia and sex, age at diagnosis of SP or initial number of colorectal polyps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In SP, rapid and unrelenting colorectal neoplasia development continues in the intact colorectum and retained segment after surgery. These findings support the possibility of annual colonoscopic surveillance, consideration for colectomy when SSA\/P or adenomas are encountered and frequent postoperative endoscopic surveillance of the retained colorectum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2011-300514","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T22:30:36Z","timestamp":1333665036000},"page":"404-408","source":"Crossref","is-referenced-by-count":93,"title":["Serrated polyposis: rapid and relentless development of colorectal neoplasia"],"prefix":"10.1136","volume":"62","author":[{"given":"Daniel L","family":"Edelstein","sequence":"first","affiliation":[{"name":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Axilbund","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M","family":"Hylind","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Romans","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance A","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Cruz-Correa","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M","family":"Giardiello","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"2025112110063392000_62.3.404.1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/64.1.1"},{"key":"2025112110063392000_62.3.404.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.065"},{"key":"2025112110063392000_62.3.404.3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.064"},{"key":"2025112110063392000_62.3.404.4","unstructured":"Giardiello FM Burt RW Jarvinen HJ . 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