{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:49:59Z","timestamp":1790056199599,"version":"4.0.1"},"reference-count":45,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2012,6,22]]},"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory complications after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether genetic factors are associated with adverse pouch outcomes such as chronic pouchitis (CP) and a Crohn's disease-like (CDL) phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>866 patients were recruited from three centres in North America: Mount Sinai Hospital (Toronto, Ontario, Canada), the Cleveland Clinic (Cleveland, Ohio, USA) and Penn State Milton S Hershey Medical Center (Hershey, Pennsylvania, USA). DNA and clinical and demographic information were collected. Subjects were classified into post-surgical outcome groups: no chronic pouchitis (NCP), CP and CDL phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clinical and genetic data were available on 714 individuals. 487 (68.2%) were classified as NCP, 118 (16.5%) CP and 109 (15.3%) CDL. The presence of arthritis or arthropathy (p=0.02), primary sclerosing cholangitis (p=0.009) and duration of time from ileostomy closure to recruitment (p=0.001) were significantly associated with outcome. The\n                      <jats:italic>NOD2<\/jats:italic>\n                      insC (rs2066847) risk variant was the single nucleotide polymorphism (SNP) most significantly associated with pouch outcome (p=7.4\u00d710\n                      <jats:sup>\u22125<\/jats:sup>\n                      ). Specifically, it was associated with both CP and CDL in comparison with NCP (OR=3.2 and 4.3, respectively). Additionally, SNPs in\n                      <jats:italic>NOX3<\/jats:italic>\n                      (rs6557421, rs12661812),\n                      <jats:italic>DAGLB<\/jats:italic>\n                      (rs836518) and\n                      <jats:italic>NCF4<\/jats:italic>\n                      (rs8137602) were shown to be associated with pouch outcome with slightly weaker effects. A multivariable risk model combining previously identified clinical (smoking status, family history of inflammatory bowel disease), serological (anti-\n                      <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                      antibody IgG, perinuclear antineutrophil cytoplasmic antibody and anti-CBir1) and genetic markers was constructed and resulted in an OR of 2.72 (p=8.89\u00d710\n                      <jats:sup>\u22127<\/jats:sup>\n                      ) for NCP versus CP\/CDL and 3.22 (p=4.11\u00d710\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) for NCP versus CDL, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Genetic polymorphisms, in particular, the\n                      <jats:italic>NOD2<\/jats:italic>\n                      insC risk allele, are associated with chronic inflammatory pouch outcomes among patients with UC and IPAA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2011-301957","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T01:09:36Z","timestamp":1344560976000},"page":"1433-1439","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":96,"title":["The\n                    <i>NOD2<\/i>\n                    insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis"],"prefix":"10.1136","volume":"62","author":[{"given":"Andrea D","family":"Tyler","sequence":"first","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M","family":"Stempak","sequence":"additional","affiliation":[{"name":"Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Hunter","family":"Brumell","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleixo M","family":"Muise","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Koltun","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"},{"name":"Department of Cellular and Molecular Physiology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Bowel Disease, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital IBD Group, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,8,9]]},"reference":[{"key":"2025121300431902000_62.10.1433.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3528(97)90053-1"},{"key":"2025121300431902000_62.10.1433.2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20897"},{"key":"2025121300431902000_62.10.1433.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01295733"},{"key":"2025121300431902000_62.10.1433.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.05.022"},{"key":"2025121300431902000_62.10.1433.5","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420170030003"},{"key":"2025121300431902000_62.10.1433.6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(85)90445-3"},{"key":"2025121300431902000_62.10.1433.7","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010136"},{"key":"2025121300431902000_62.10.1433.8","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410004668"},{"key":"2025121300431902000_62.10.1433.9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.6.690"},{"key":"2025121300431902000_62.10.1433.10","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20409"},{"key":"2025121300431902000_62.10.1433.11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20646"},{"key":"2025121300431902000_62.10.1433.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9158-3"},{"key":"2025121300431902000_62.10.1433.13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234133"},{"key":"2025121300431902000_62.10.1433.14","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.3748\/wjg.v11.i46.7323","article-title":"Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis","volume":"11","author":"Lammers","year":"2005","journal-title":"World J Gastroenterol"},{"key":"2025121300431902000_62.10.1433.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04107.x"},{"key":"2025121300431902000_62.10.1433.16","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28017"},{"key":"2025121300431902000_62.10.1433.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2007.10.003"},{"key":"2025121300431902000_62.10.1433.18","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"2025121300431902000_62.10.1433.19","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"2025121300431902000_62.10.1433.20","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181f22635"},{"key":"2025121300431902000_62.10.1433.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.016"},{"issue":"Suppl A","key":"2025121300431902000_62.10.1433.22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"key":"2025121300431902000_62.10.1433.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.006"},{"key":"2025121300431902000_62.10.1433.24","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2025121300431902000_62.10.1433.25","doi-asserted-by":"publisher","DOI":"10.1159\/000064976"},{"key":"2025121300431902000_62.10.1433.26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.186"},{"key":"2025121300431902000_62.10.1433.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01413.x"},{"key":"2025121300431902000_62.10.1433.28","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.76"},{"key":"2025121300431902000_62.10.1433.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40304.x"},{"key":"2025121300431902000_62.10.1433.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05063-7"},{"key":"2025121300431902000_62.10.1433.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.04.013"},{"key":"2025121300431902000_62.10.1433.32","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21339"},{"key":"2025121300431902000_62.10.1433.33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.219667"},{"key":"2025121300431902000_62.10.1433.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2008.00795.x"},{"key":"2025121300431902000_62.10.1433.35","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000186407.25694.cf"},{"key":"2025121300431902000_62.10.1433.36","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21579"},{"key":"2025121300431902000_62.10.1433.37","first-page":"179","article-title":"NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2","volume":"17","author":"Muise","year":"2011","journal-title":"Gut"},{"key":"2025121300431902000_62.10.1433.38","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301344"},{"key":"2025121300431902000_62.10.1433.39","doi-asserted-by":"publisher","DOI":"10.1042\/bj2960557"},{"key":"2025121300431902000_62.10.1433.40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414548200"},{"key":"2025121300431902000_62.10.1433.41","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.057"},{"key":"2025121300431902000_62.10.1433.42","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199610000-00003"},{"key":"2025121300431902000_62.10.1433.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.01.002"},{"key":"2025121300431902000_62.10.1433.44","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.671"},{"key":"2025121300431902000_62.10.1433.45","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.013"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gutjnl-2011-301957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:43:27Z","timestamp":1765615407000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gutjnl-2011-301957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,9]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,9,14]]},"published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1136\/gutjnl-2011-301957"],"URL":"https:\/\/doi.org\/10.1136\/gutjnl-2011-301957","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,9]]}}}