{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:28:58Z","timestamp":1793219338060,"version":"4.5.0"},"reference-count":41,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2012,4,10]]},"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral contraceptive use has been associated with risk of Crohn's disease (CD) and ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether this association is confounded or modified by other important lifestyle and reproductive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective cohort study was carried out of 117\u2008375 US women enrolled since 1976 in the Nurses Health Study I (NHS I) and 115\u2008077 women enrolled since 1989 in the Nurses' Health Study II (NHS II) with no prior history of UC or CD. These women had provided information every 2\u2005years, on age at menarche, oral contraceptive use, parity, menopause status and other risk factors. Diagnoses of CD and UC were confirmed by review of medical records. Cox proportional hazards models were used to calculate HRs and 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 232\u2008452 women with over 5\u2008030\u2008196 person-years of follow-up, 315 cases of CD and 392 cases of UC were recorded through 2007 in NHS II and 2008 in NHS I. Compared with never users of oral contraceptives, the multivariate-adjusted HRs for CD were 2.82 (95% CI 1.65 to 4.82) among current users and 1.39 (95% CI 1.05 to 1.85) among past users. The association between oral contraceptives and UC differed according to smoking history (p\n                      <jats:sub>heterogeneity<\/jats:sub>\n                      =0.04). Age at menarche, age at first birth and parity were not associated with risk of UC or CD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In two large prospective cohorts of US women, oral contraceptive use was associated with risk of CD. The association between oral contraceptive use and UC was limited to women with a history of smoking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2012-302362","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T22:21:57Z","timestamp":1337725317000},"page":"1153-1159","source":"Crossref","is-referenced-by-count":183,"title":["Oral contraceptives, reproductive factors and risk of inflammatory bowel disease"],"prefix":"10.1136","volume":"62","author":[{"given":"Hamed","family":"Khalili","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, 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