{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:37:03Z","timestamp":1791639423394,"version":"4.3.4"},"reference-count":76,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2012,9,17]]},"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Screening individuals at increased risk for pancreatic cancer (PC) detects early, potentially curable, pancreatic neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop consortium statements on screening, surveillance and management of high-risk individuals with an inherited predisposition to PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 49-expert multidisciplinary international consortium met to discuss pancreatic screening and vote on statements. Consensus was considered reached if \u226575% agreed or disagreed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was excellent agreement that, to be successful, a screening programme should detect and treat T1N0M0 margin-negative PC and high-grade dysplastic precursor lesions (pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm). It was agreed that the following were candidates for screening: first-degree relatives (FDRs) of patients with PC from a familial PC kindred with at least two affected FDRs; patients with Peutz\u2013Jeghers syndrome; and\n                      <jats:italic>p16<\/jats:italic>\n                      ,\n                      <jats:italic>BRCA<\/jats:italic>\n                      2 and hereditary non-polyposis colorectal cancer (HNPCC) mutation carriers with \u22651 affected FDR. Consensus was not reached for the age to initiate screening or stop surveillance. It was agreed that initial screening should include endoscopic ultrasonography (EUS) and\/or MRI\/magnetic resonance cholangiopancreatography not CT or endoscopic retrograde cholangiopancreatography. There was no consensus on the need for EUS fine-needle aspiration to evaluate cysts. There was disagreement on optimal screening modalities and intervals for follow-up imaging. When surgery is recommended it should be performed at a high-volume centre. There was great disagreement as to which screening abnormalities were of sufficient concern to for surgery to be recommended.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Screening is recommended for high-risk individuals, but more evidence is needed, particularly for how to manage patients with detected lesions. Screening and subsequent management should take place at high-volume centres with multidisciplinary teams, preferably within research protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2012-303108","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T01:07:00Z","timestamp":1352336820000},"page":"339-347","source":"Crossref","is-referenced-by-count":676,"title":["International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer"],"prefix":"10.1136","volume":"62","author":[{"given":"Marcia Irene","family":"Canto","sequence":"first","affiliation":[{"name":"Department of Medicine (Gastroenterology), Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femme","family":"Harinck","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H","family":"Hruban","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Johan","family":"Offerhaus","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Werner","family":"Poley","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung","family":"Nio","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Schulick","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Kluijt","sequence":"additional","affiliation":[{"name":"Department of Oncology, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabh","family":"Chak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University Hospitals of Cleveland, Cleveland Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fockens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goggins","sequence":"additional","affiliation":[{"name":"Department of Medicine (Gastroenterology), Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"2025120519323961000_62.3.339.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"2025120519323961000_62.3.339.2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11605-011-1781-6","article-title":"Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience","volume":"16","author":"Al-Sukhni","year":"2011","journal-title":"J Gastrointest Surg"},{"key":"2025120519323961000_62.3.339.3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.68"},{"key":"2025120519323961000_62.3.339.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.02.005"},{"key":"2025120519323961000_62.3.339.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00244-7"},{"key":"2025120519323961000_62.3.339.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.171611"},{"key":"2025120519323961000_62.3.339.7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.65"},{"key":"2025120519323961000_62.3.339.8","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.276"},{"key":"2025120519323961000_62.3.339.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.048"},{"key":"2025120519323961000_62.3.339.10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-3209"},{"key":"2025120519323961000_62.3.339.11","doi-asserted-by":"crossref","unstructured":"Canto MI Hruban RH Fishman EK . Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals. Gastroenterology 2012.","DOI":"10.1053\/j.gastro.2012.01.005"},{"key":"2025120519323961000_62.3.339.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"2025120519323961000_62.3.339.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"2025120519323961000_62.3.339.14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a744"},{"key":"2025120519323961000_62.3.339.15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2452"},{"key":"2025120519323961000_62.3.339.16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3823"},{"key":"2025120519323961000_62.3.339.17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.012"},{"key":"2025120519323961000_62.3.339.18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp466"},{"key":"2025120519323961000_62.3.339.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2010.05.011"},{"key":"2025120519323961000_62.3.339.20","first-page":"5360","article-title":"Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas","volume":"56","author":"Goggins","year":"1996","journal-title":"Cancer Res"},{"key":"2025120519323961000_62.3.339.21","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20228"},{"key":"2025120519323961000_62.3.339.22","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.725"},{"key":"2025120519323961000_62.3.339.23","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0783"},{"key":"2025120519323961000_62.3.339.24","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.3.214"},{"key":"2025120519323961000_62.3.339.25","first-page":"3789","article-title":"Evaluation of candidate genes MAP2K4, MADH4, ACVR1B and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%","volume":"62","author":"Murphy","year":"2002","journal-title":"Cancer Res"},{"key":"2025120519323961000_62.3.339.26","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-199912000-00003"},{"key":"2025120519323961000_62.3.339.27","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.028829"},{"key":"2025120519323961000_62.3.339.28","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-198"},{"key":"2025120519323961000_62.3.339.29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.5546"},{"key":"2025120519323961000_62.3.339.30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.18.1358"},{"key":"2025120519323961000_62.3.339.31","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171202"},{"key":"2025120519323961000_62.3.339.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01425.x"},{"key":"2025120519323961000_62.3.339.33","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.055"},{"key":"2025120519323961000_62.3.339.34","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-010-9414-x"},{"key":"2025120519323961000_62.3.339.35","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.226"},{"key":"2025120519323961000_62.3.339.36","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.043802"},{"key":"2025120519323961000_62.3.339.37","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-007-9166-4"},{"key":"2025120519323961000_62.3.339.38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0403"},{"key":"2025120519323961000_62.3.339.39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5590"},{"key":"2025120519323961000_62.3.339.40","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1529"},{"key":"2025120519323961000_62.3.339.41","first-page":"1501","article-title":"Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern and pushing borders suggest RER+","volume":"152","author":"Goggins","year":"1998","journal-title":"Am J Pathol"},{"key":"2025120519323961000_62.3.339.42","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.6.442"},{"key":"2025120519323961000_62.3.339.43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00115.2004"},{"key":"2025120519323961000_62.3.339.44","first-page":"73","article-title":"Hereditary pancreatitis and secondary screening for early pancreatic cancer","volume":"50","author":"Vitone","year":"2005","journal-title":"Rocz Akad Med Bialymst"},{"key":"2025120519323961000_62.3.339.45","doi-asserted-by":"publisher","DOI":"10.1159\/000055841"},{"key":"2025120519323961000_62.3.339.46","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-4-199908170-00003"},{"key":"2025120519323961000_62.3.339.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70092-8"},{"key":"2025120519323961000_62.3.339.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.09.018"},{"key":"2025120519323961000_62.3.339.49","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.013"},{"key":"2025120519323961000_62.3.339.50","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31821bd62f"},{"key":"2025120519323961000_62.3.339.51","doi-asserted-by":"publisher","DOI":"10.1159\/000090023"},{"key":"2025120519323961000_62.3.339.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.04.016"},{"key":"2025120519323961000_62.3.339.53","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25148"},{"key":"2025120519323961000_62.3.339.54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1010705"},{"key":"2025120519323961000_62.3.339.55","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7581"},{"key":"2025120519323961000_62.3.339.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2012.04.004"},{"key":"2025120519323961000_62.3.339.57","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1745-9"},{"key":"2025120519323961000_62.3.339.58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"2025120519323961000_62.3.339.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2006.08.018"},{"key":"2025120519323961000_62.3.339.60","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181613142"},{"key":"2025120519323961000_62.3.339.61","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2009.282"},{"key":"2025120519323961000_62.3.339.62","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806303182605"},{"key":"2025120519323961000_62.3.339.63","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21889"},{"key":"2025120519323961000_62.3.339.64","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00003"},{"key":"2025120519323961000_62.3.339.65","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200105000-00003"},{"key":"2025120519323961000_62.3.339.66","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/00000478-200107000-00014","article-title":"The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma","volume":"25","author":"Luttges","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2025120519323961000_62.3.339.67","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00009"},{"key":"2025120519323961000_62.3.339.68","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0004"},{"key":"2025120519323961000_62.3.339.69","first-page":"515","article-title":"K-ras mutation in focal proliferative lesions of human pancreas","volume":"7","author":"Terhune","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025120519323961000_62.3.339.70","doi-asserted-by":"publisher","DOI":"10.1038\/nature09515"},{"key":"2025120519323961000_62.3.339.71","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002543"},{"key":"2025120519323961000_62.3.339.72","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.2"},{"key":"2025120519323961000_62.3.339.73","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63053-2"},{"key":"2025120519323961000_62.3.339.74","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000128306.90650.aa"},{"key":"2025120519323961000_62.3.339.75","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255971"},{"key":"2025120519323961000_62.3.339.76","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145631"}],"updated-by":[{"DOI":"10.1136\/gutjnl-2012-303108corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000}},{"DOI":"10.1136\/gutjnl-2012-303108corr2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000}},{"DOI":"10.1136\/gutjnl-2012-303108corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000}},{"DOI":"10.1136\/gutjnl-2012-303108corr2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000}}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gutjnl-2012-303108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:32:49Z","timestamp":1764991969000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gutjnl-2012-303108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,7]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,1,31]]},"published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1136\/gutjnl-2012-303108"],"URL":"https:\/\/doi.org\/10.1136\/gutjnl-2012-303108","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,7]]}}}