{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T15:27:40Z","timestamp":1794497260531,"version":"4.9.1"},"reference-count":50,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2013,5,14]]},"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The differential role of the IL-1 agonists, IL-1\u03b1, which is mainly cell-associated versus IL-1\u03b2, which is mostly secreted, was studied in colon inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1\u03b1 or IL-1\u03b2, and in wild-type mice, or in mice with conditional deletion of IL-1\u03b1 in intestinal epithelial cells (IECs). Bone marrow transplantation experiments were performed to assess the role of IL-1\u03b1 or IL-1\u03b2 of myeloid versus colon non-hematopoietic cells in inflammation and repair in acute colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL-1\u03b1 released from damaged IECs acts as an alarmin by initiating and propagating colon inflammation, as IL-1\u03b1 deficient mice exhibited mild disease symptoms with improved recovery. IL-1\u03b2 is involved in repair of IECs and reconstitution of the epithelial barrier during the resolution of colitis; its deficiency correlates with disease exacerbation. Neutralisation of IL-1\u03b1 in control mice during acute colitis led to alleviation of clinical and histological manifestations, whereas treatment with rIL-1Ra or anti-IL-1\u03b2 antibodies was not effective. Repair after colitis correlated with accumulation of CD8 and regulatory T cells in damaged crypts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The role of IL-1\u03b1 and IL-1\u03b2 differs in DSS-induced colitis in that IL-1\u03b1, mainly of colon epithelial cells is inflammatory, whereas IL-1\u03b2, mainly of myeloid cell origin, promotes healing and repair. Given the dissimilar functions of each IL-1 agonistic molecule, an IL-1 receptor blockade would not be as therapeutically effective as specific neutralising of IL-1\u03b1, which leaves IL-1\u03b2 function intact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2012-303329","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T21:41:34Z","timestamp":1371850894000},"page":"598-609","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":230,"title":["Non-redundant properties of IL-1\u03b1 and IL-1\u03b2 during acute colon inflammation in mice"],"prefix":"10.1136","volume":"63","author":[{"given":"Marina","family":"Bersudsky","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, The Shraga Segal Department of Microbiology and Immunology and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, 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