{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:39:54Z","timestamp":1783471194893,"version":"3.55.0"},"reference-count":48,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2012,12,7]]},"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Barrett's oesophagus is a precursor lesion of oesophageal adenocarcinoma, a cancer that, in the USA, has increased in incidence over 600% during the past 40\u2005years. Barrett's oesophagus and oesophageal adenocarcinoma are much more common among men than among women; this finding is unexplained and most earlier studies lacked sufficient numbers of women to evaluate sex-specific risk factors. We leveraged the power of an international consortium to assess sex-specific relationships between body mass index (BMI), abdominal circumference and Barrett's oesophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Four case\u2013control studies provided a total of 1102 cases (316 women, 786 men) and 1400 population controls (436 women, 964 men) for analysis. Study-specific estimates, generated using individual participant data, were combined using random effects meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Waist circumference was significantly associated with Barrett's oesophagus, even after adjustment for BMI; persons in the highest versus the lowest quartiles of waist circumference had approximately 125% and 275% increases in the odds of Barrett's oesophagus among men and women, respectively (OR 2.24, 95% CI 1.08 to 4.65, I\n                      <jats:sup>2<\/jats:sup>\n                      =57; OR 3.75, 95% CI 1.47 to 9.56, I\n                      <jats:sup>2<\/jats:sup>\n                      =0). In contrast, there was no evidence of a significant association between BMI and the risk of Barrett's oesophagus, with or without adjustment for waist circumference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Waist circumference, independent of BMI, was found to be a risk factor for Barrett's oesophagus among both men and women. Future studies examining the biological mechanisms of this association will extend our knowledge regarding the pathogenesis of Barrett's oesophagus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2012-303753","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T20:09:49Z","timestamp":1359230989000},"page":"1684-1691","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":119,"title":["Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium"],"prefix":"10.1136","volume":"62","author":[{"given":"Ai","family":"Kubo","sequence":"first","affiliation":[{"name":"Division of Research, Northern California Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Blaise","family":"Cook","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fred Hutchinson Cancer Center, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Department of Population and Cancer Studies, Queensland Institute of Medical Research, Brisbane, Queensland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Medicine, Belfast, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Corley","sequence":"additional","affiliation":[{"name":"Division of Research, Northern California Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,26]]},"reference":[{"key":"2025120600260403000_62.12.1684.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510110055030"},{"key":"2025120600260403000_62.12.1684.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025120600260403000_62.12.1684.3","first-page":"2","article-title":"The changing epidemiology of esophageal cancer","volume":"26","author":"Blot","year":"1999","journal-title":"Semin Oncol"},{"key":"2025120600260403000_62.12.1684.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04131.x"},{"key":"2025120600260403000_62.12.1684.5","first-page":"1293","article-title":"Risk factors for Barrett's esophagus in community-based practice. 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