{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:43:10Z","timestamp":1791164590295,"version":"4.1.0"},"reference-count":58,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1136\/gutjnl-2014-308153","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T02:31:23Z","timestamp":1431484283000},"page":"1269-1278","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease"],"prefix":"10.1136","volume":"65","author":[{"given":"Frederike","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Kooy-Winkelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Sophia","family":"Wiekmeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn H","family":"Brugman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Luisa","family":"Mearin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Chuva de Sousa Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L","family":"Mummery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank JT","family":"Staal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"key-10.1136\/gutjnl-2014-308153-1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni1101-997","article-title":"Intraepithelial lymphocytes: exploring the Third Way in immunology","volume":"2","author":"Hayday","year":"2001","journal-title":"Nat Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005176-198908000-00007","article-title":"Heterogeneity in intraepithelial lymphocyte subpopulations in fetal and postnatal human small-intestine","volume":"9","author":"Spencer","year":"1989","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"key-10.1136\/gutjnl-2014-308153-3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/gut.30.3.339","article-title":"Changes in intraepithelial lymphocyte subpopulations in celiac-disease and enteropathy associated T-cell lymphoma (malignant histiocytosis of the intestine)","volume":"30","author":"Spencer","year":"1989","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/eji.1830200523","article-title":"Subsets of Cd3+ (T-cell receptor-alpha-beta or gamma-delta) and Cd3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral-blood","volume":"20","author":"Jarry","year":"1990","journal-title":"Eur J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-5","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1084\/jem.155.6.1785","article-title":"Characteristics of natural-killer cells in the murine intestinal epithelium and lamina propria","volume":"155","author":"Tagliabue","year":"1982","journal-title":"J Exp Med"},{"key":"key-10.1136\/gutjnl-2014-308153-6","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/intimm\/7.9.1473","article-title":"Intraepithelial lymphocytes\u2014evidence for regional specialization and extrathymic T-cell maturation in the human gut epithelium","volume":"7","author":"Lundqvist","year":"1995","journal-title":"Int Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-3083.2000.00761.x","article-title":"Intestinal intraepithelial lymphocytes contain a CD3(-) CD7(+) subset expressing natural killer markers and a singular pattern of adhesion molecules","volume":"52","author":"Eiras","year":"2000","journal-title":"Scand J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/(SICI)1097-0320(19980415)34:2<95::AID-CYTO6>3.0.CO;2-B","article-title":"Flow cytometry description of a novel CD3-\/CD7+ intraepithelial lymphocyte subset in human duodenal biopsies: potential diagnostic value in coeliac disease","volume":"34","author":"Eiras","year":"1998","journal-title":"Cytometry"},{"key":"key-10.1136\/gutjnl-2014-308153-9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0016-5085(03)00886-2","article-title":"Human small-intestinal epithelium contains functional natural killer lymphocytes","volume":"125","author":"Leon","year":"2003","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2013.02.010","article-title":"Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-gamma-producing cells","volume":"38","author":"Fuchs","year":"2013","journal-title":"Immunity"},{"key":"key-10.1136\/gutjnl-2014-308153-11","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.4049\/jimmunol.174.9.5414","article-title":"Phenotypic characterization of CD3(-)7(+) cells in developing human intestine and an analysis of their ability to differentiate into T cells","volume":"174","author":"Gunther","year":"2005","journal-title":"J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-12","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.4049\/jimmunol.161.11.5862","article-title":"Extrathymic T cell differentiation in the human intestine early in life","volume":"161","author":"Howie","year":"1998","journal-title":"J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/gutjnl-2012-302265","article-title":"Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II","volume":"62","author":"Schmitz","year":"2013","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2014a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1182\/blood-2013-11-427781","article-title":"Human innate lymphoid cells","volume":"124","author":"Hazenberg","year":"2014","journal-title":"Blood"},{"key":"key-10.1136\/gutjnl-2014-308153-16","first-page":"285","article-title":"Intraepithelial lymphocytes and coeliac disease: permanent changes in CD3(-)\/CD7(+) and T cell receptor gamma delta subsets studied by flow cytometry","volume":"89","author":"Camarero","year":"2000","journal-title":"Acta Paediatrica"},{"key":"key-10.1136\/gutjnl-2014-308153-17","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s10620-010-1534-5","article-title":"Dynamics of non-conventional intraepithelial lymphocytes-NK, NKT, and gamma delta T-in celiac disease: relationship with age, diet, and histopathology","volume":"56","author":"Calleja","year":"2011","journal-title":"Dig Dis Sci"},{"key":"key-10.1136\/gutjnl-2014-308153-18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/gut.34.2.208","article-title":"Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet","volume":"34","author":"Kutlu","year":"1993","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1365-2249.1999.00948.x","article-title":"Changing jejunal gamma delta T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease","volume":"117","author":"Iltanen","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0016-5085(98)70530-X","article-title":"Abnormal intestinal intraepithelial lymphocytes in refractory sprue","volume":"114","author":"Cellier","year":"1998","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-21","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1182\/blood-2008-04-150748","article-title":"Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma","volume":"112","author":"Tjon","year":"2008","journal-title":"Blood"},{"key":"key-10.1136\/gutjnl-2014-308153-22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.molimm.2012.01.014","article-title":"Origin and immunophenotype of aberrant IEL in RCDII patients","volume":"50","author":"Tack","year":"2012","journal-title":"Mol Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/gut.2005.068684","article-title":"Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease","volume":"55","author":"Di Sabatino","year":"2006","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/gut.2007.129882","article-title":"Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease","volume":"57","author":"Fina","year":"2008","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0016-5085(03)01047-3","article-title":"Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease","volume":"125","author":"Mention","year":"2003","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-26","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/mi.2013.19","article-title":"Increased production of interleukin-21, but not interleukin-17A, in the small intestine characterizes pediatric celiac disease","volume":"6","author":"van Leeuwen","year":"2013","journal-title":"Mucosal Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"Hue","year":"2004","journal-title":"Immunity"},{"key":"key-10.1136\/gutjnl-2014-308153-28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"},{"key":"key-10.1136\/gutjnl-2014-308153-29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/mi.2012.65","article-title":"IL-15 positively regulates IL-21 production in celiac disease mucosa","volume":"6","author":"Sarra","year":"2013","journal-title":"Mucosal Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/mi.2010.36","article-title":"HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22","volume":"3","author":"Bodd","year":"2010","journal-title":"Mucosal Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrd4296","article-title":"Interleukin-21: a double-edged sword with therapeutic potential","volume":"13","author":"Spolski","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"key-10.1136\/gutjnl-2014-308153-32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1136\/gut.2007.141994","article-title":"The cytokine interleukin 21: a new player in coeliac disease?","volume":"57","author":"Meresse","year":"2008","journal-title":"Gut"},{"key":"key-10.1136\/gutjnl-2014-308153-33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2006.09.053","article-title":"A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells","volume":"132","author":"Caruso","year":"2007","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-35","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S1074-7613(02)00474-0","article-title":"Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro","volume":"17","author":"Schmitt","year":"2002","journal-title":"Immunity"},{"key":"key-10.1136\/gutjnl-2014-308153-36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1309\/5PRJ-CM0U-6KLD-6KCM","article-title":"Morphologic features suggestive of gluten sensitivity in architecturally normal duodenal biopsy specimens","volume":"116","author":"Goldstein","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"key-10.1136\/gutjnl-2014-308153-37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2249.1991.tb05690.x","article-title":"Gamma-delta T-Cells and the diagnosis of celiac-disease","volume":"85","author":"Spencer","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-38","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1172\/JCI41344","article-title":"IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis","volume":"120","author":"Malamut","year":"2010","journal-title":"J Clin Invest"},{"key":"key-10.1136\/gutjnl-2014-308153-39","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.4049\/jimmunol.149.6.1876","article-title":"Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes","volume":"149","author":"Lanier","year":"1992","journal-title":"J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nri1257","article-title":"T-cell development made simple","volume":"4","author":"Zuniga-Pflucker","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-41","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1182\/blood-2007-03-082206","article-title":"Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells","volume":"110","author":"De Smedt","year":"2007","journal-title":"Blood"},{"key":"key-10.1136\/gutjnl-2014-308153-42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/002215540405200409","article-title":"Expression of Notch receptors and ligands in the adult gut","volume":"52","author":"Sander","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"key-10.1136\/gutjnl-2014-308153-43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-physiol-030212-183741","article-title":"Notch in the intestine: regulation of homeostasis and pathogenesis","volume":"75","author":"Noah","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"key-10.1136\/gutjnl-2014-308153-44","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MOG.0b013e328365d339","article-title":"Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract","volume":"29","author":"Fuchs","year":"2013","journal-title":"Curr Opin Gastroenterol"},{"key":"key-10.1136\/gutjnl-2014-308153-45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nature13047","article-title":"A committed precursor to innate lymphoid cells","volume":"508","author":"Constantinides","year":"2014","journal-title":"Nature"},{"key":"key-10.1136\/gutjnl-2014-308153-46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"key-10.1136\/gutjnl-2014-308153-47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-48","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"key-10.1136\/gutjnl-2014-308153-49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ni.1668","article-title":"Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells","volume":"10","author":"Cupedo","year":"2009","journal-title":"Nat Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.immuni.2005.01.013","article-title":"A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells","volume":"22","author":"Freud","year":"2005","journal-title":"Immunity"},{"key":"key-10.1136\/gutjnl-2014-308153-51","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1084\/jem.20052507","article-title":"Evidence for discrete stages of human natural killer cell differentiation in vivo","volume":"203","author":"Freud","year":"2006","journal-title":"J Exp Med"},{"key":"key-10.1136\/gutjnl-2014-308153-52","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1002\/eji.201141760","article-title":"NK cells can generate from precursors in the adult human liver","volume":"41","author":"Moroso","year":"2011","journal-title":"Eur J Immunol"},{"key":"key-10.1136\/gutjnl-2014-308153-53","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1073\/pnas.1016257108","article-title":"CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells","volume":"108","author":"Vacca","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.1136\/gutjnl-2014-308153-54","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1084\/jem.178.6.1857","article-title":"Human natural killer cell committed thymocytes and their relation to the T cell lineage","volume":"178","author":"Sanchez","year":"1993","journal-title":"J Exp Med"},{"key":"key-10.1136\/gutjnl-2014-308153-55","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.gastro.2007.05.017","article-title":"Lamina propria c-kit(+) immune precursors reside in human adult intestine and differentiate into natural killer cells","volume":"133","author":"Chinen","year":"2007","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0016-5085(03)00692-9","article-title":"Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue","volume":"125","author":"Verkarre","year":"2003","journal-title":"Gastroenterology"},{"key":"key-10.1136\/gutjnl-2014-308153-57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1073\/pnas.0509575103","article-title":"Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia","volume":"103","author":"Morris","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.1136\/gutjnl-2014-308153-58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(00)02481-8","article-title":"Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma","volume":"356","author":"Cellier","year":"2000","journal-title":"Lancet"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gutjnl-2014-308153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T12:45:47Z","timestamp":1691671547000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gutjnl-2014-308153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,7,8]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1136\/gutjnl-2014-308153"],"URL":"https:\/\/doi.org\/10.1136\/gutjnl-2014-308153","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}