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These findings come to challenge the traditional view of FGIDs as pure functional disorders, and relate the origin to a tangible organic substrate. The mucosal inflammatory infiltrate is dominated by mast cells, eosinophils and intraepithelial lymphocytes in the intestine of FGIDs. It is well established that mast cell activation can generate epithelial and neuro-muscular dysfunction and promote visceral hypersensitivity and altered motility patterns in FGIDs, postoperative ileus, food allergy and inflammatory bowel disease. This review will discuss the role of mucosal mast cells in the gastrointestinal tract with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.<\/jats:p>","DOI":"10.1136\/gutjnl-2015-309151","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T19:48:37Z","timestamp":1448912917000},"page":"155-168","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":286,"title":["The role of mast cells in functional GI disorders"],"prefix":"10.1136","volume":"65","author":[{"given":"Mira M","family":"Wouters","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vicario","sequence":"additional","affiliation":[{"name":"Neuro-immuno-gastroenterology Laboratory, Digestive Diseases Research Unit. 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