{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:44:13Z","timestamp":1788975853591,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"3","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Z01 CP010180-15"],"award-info":[{"award-number":["Z01 CP010180-15"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2016,12,4]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Barrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10\u201355 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995\u20132012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 8929 patients with BE providing 50\u2005147 person-years of follow-up. Compared with the greater KPNC population, patients with BE had increased risks of any cancer (SIR=1.40, 95% CI 1.31 to 1.49), which slightly decreased after excluding oesophageal cancer. Oesophageal adenocarcinoma risk was increased 24 times, which translated into an excess absolute risk of 24 cases per 10\u2005000 person-years. Although oesophageal adenocarcinoma risk decreased with time since BE diagnosis, oesophageal cancer mortality did not, indicating that the true risk is stable and persistent with time. Relative risks of cardia and stomach cancers were increased, but excess absolute risks were modest. Risks of colorectal, lung and prostate cancers were unaltered. All-cause mortality was slightly increased after excluding oesophageal cancer (SMR=1.24, 95% CI 1.18 to 1.31), but time-stratified analyses indicated that this was likely attributable to diagnostic bias. Cause-specific SMRs were elevated for ischaemic heart disease (SMR=1.39, 95% CI 1.18 to 1.63), respiratory system diseases (SMR=1.51, 95% CI 1.29 to 1.75) and digestive system diseases (SMR=2.20 95% CI 1.75 to 2.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with BE had a persistent excess risk of oesophageal adenocarcinoma over time, although their absolute excess risks for this cancer, any cancer and overall mortality were modest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2016-312223","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T21:40:20Z","timestamp":1483566020000},"page":"418-529","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Cancer incidence and mortality risks in a large US Barrett's oesophagus cohort"],"prefix":"10.1136","volume":"67","author":[{"given":"Michael B","family":"Cook","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally B","family":"Coburn","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson R","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Research, Oakland Medical Center, Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Research, Oakland Medical Center, Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Corley","sequence":"additional","affiliation":[{"name":"Division of Research, Oakland Medical Center, Kaiser Permanente, Oakland, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"2025112110315232000_67.3.418.1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","article-title":"Adenocarcinoma and Barrett's esophagus. 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How does the adult Kaiser Permanente membership in Northern California compare with the larger community? 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