{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T17:42:55Z","timestamp":1794678175573,"version":"4.9.1"},"reference-count":18,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n Objective<\/jats:title>\n Ciclosporin and infliximab have demonstrated short-term similar efficacy as second-line therapies in patients with acute severe UC (ASUC) refractory to intravenous steroids. The aim of this study was to assess long-term outcome of patients included in a randomised trial comparing ciclosporin and infliximab.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Between 2007 and 2010, 115 patients with steroid-refractory ASUC were randomised in 29 European centres to receive ciclosporin or infliximab in association with azathioprine. Patients were followed until death or last news up to January 2015. Colectomy-free survival rates at 1 and 5\u2005years and changes in therapy were estimated through Kaplan-Meier method and compared between initial treatment groups through log-rank test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After a median follow-up of 5.4\u2005years, colectomy-free survival rates (95% CI) at 1 and 5\u2005years were, respectively, 70.9% (59.2% to 82.6%) and 61.5% (48.7% to 74.2%) in patients who received ciclosporin and 69.1% (56.9% to 81.3%) and 65.1% (52.4% to 77.8%) in those who received infliximab (p=0.97). Cumulative incidence of first infliximab use at 1 and 5\u2005years in patients initially treated with ciclosporin was, respectively, 45.7% (32.6% to 57.9%) and 57.1% (43.0% to 69.0%). Only four patients from the infliximab group were subsequently switched to ciclosporin. Three patients died during the follow-up, none directly related to UC or its treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this cohort of patients with steroid-refractory ASUC initially treated by ciclosporin or infliximab, long-term colectomy-free survival was independent from initial treatment. These long-term results further confirm a similar efficacy and good safety profiles of both drugs and do not favour one drug over the other.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n \n EudraCT: 2006-005299-42; ClinicalTrials.gouv number:\n NCT00542152<\/jats:ext-link>\n ; post-results.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/gutjnl-2016-313060","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T21:40:20Z","timestamp":1483566020000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or 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