{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:27:09Z","timestamp":1792819629757,"version":"4.5.0"},"reference-count":239,"publisher":"BMJ","issue":"8","funder":[{"name":"Competitive Research Funding of the Tampere University Hospital"},{"name":"Leibniz Foundation"},{"name":"Ministry of Research and Development (BMBF), Germany"},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian Research Fund"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"itive State Research Financing of the Tampere University"},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Sigrid Juselius Foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2018,1,8]]},"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Based on a literature review of 10\u2009062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2017-314853","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T13:32:55Z","timestamp":1518528775000},"page":"1410-1424","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Outcome measures in coeliac disease trials: the Tampere recommendations"],"prefix":"10.1136","volume":"67","clinical-trial-number":[{"clinical-trial-number":"nct02637141","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02633020","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5602","authenticated-orcid":false,"given":"Jonas F","family":"Ludvigsson","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Pediatrics, \u00d6rebro University Hospital, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ciacci","sequence":"additional","affiliation":[{"name":"Coeliac Center at Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter HR","family":"Green","sequence":"additional","affiliation":[{"name":"Celiac Disease Center at Columbia University, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Kaukinen","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilma R","family":"Korponay-Szabo","sequence":"additional","affiliation":[{"name":"Coeliac Disease Centre, Heim P\u00e1l Children\u2019s Hospital, Budapest, Hungary"},{"name":"Department of Paediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Department of Paediatrics, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Murray","sequence":"additional","affiliation":[{"name":"The Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut Erik Aslaksen","family":"Lundin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine and K.G. Jebsen Coeliac Disease Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Gastroenterology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku J","family":"Maki","sequence":"additional","affiliation":[{"name":"Science Center, Tampere University Hospital, Tampere, Finland"},{"name":"Tampere Centre for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popp","sequence":"additional","affiliation":[{"name":"Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy \u2019Carol Davila', Bucharest, Romania"},{"name":"Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norelle R","family":"Reilly","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Columbia University Medical Center, New York, USA"},{"name":"Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Rodriguez-Herrera","sequence":"additional","affiliation":[{"name":"Grupo IHP Pediatria, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Sanders","sequence":"additional","affiliation":[{"name":"Academic Unit of Gastroenterology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[{"name":"Celiac Center, University Medical Center, Johannes-Gutenberg University, Mainz, Germany"},{"name":"Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sleet","sequence":"additional","affiliation":[{"name":"Coeliac UK, Buckinghamshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Taavela","sequence":"additional","affiliation":[{"name":"Tampere Centre for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Voorhees","sequence":"additional","affiliation":[{"name":"Continuum Clinical, Northbrook, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie M","family":"Walker","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Leffler","sequence":"additional","affiliation":[{"name":"Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"2025121307531516000_67.8.1410.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4347"},{"key":"2025121307531516000_67.8.1410.2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2036.2006.03203.x","article-title":"Coeliac disease and the risk of fractures - a general population-based cohort study","volume":"25","author":"Ludvigsson","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq564"},{"key":"2025121307531516000_67.8.1410.4","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.194"},{"key":"2025121307531516000_67.8.1410.5","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13652"},{"key":"2025121307531516000_67.8.1410.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1320"},{"key":"2025121307531516000_67.8.1410.7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"2025121307531516000_67.8.1410.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"2025121307531516000_67.8.1410.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.007"},{"key":"2025121307531516000_67.8.1410.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03502.x"},{"key":"2025121307531516000_67.8.1410.11","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.55"},{"key":"2025121307531516000_67.8.1410.12","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614560786"},{"key":"2025121307531516000_67.8.1410.13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.29"},{"key":"2025121307531516000_67.8.1410.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2007.00763.x"},{"key":"2025121307531516000_67.8.1410.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2011.01160.x"},{"key":"2025121307531516000_67.8.1410.16","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133395"},{"key":"2025121307531516000_67.8.1410.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02376.x"},{"key":"2025121307531516000_67.8.1410.18","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.105"},{"key":"2025121307531516000_67.8.1410.19","first-page":"27","article-title":"Are patients with coeliac disease seeking alternative therapies to a gluten-free diet?","volume":"20","author":"Aziz","year":"2011","journal-title":"J Gastrointestin Liver Dis"},{"key":"2025121307531516000_67.8.1410.20","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312762"},{"key":"2025121307531516000_67.8.1410.21","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"2025121307531516000_67.8.1410.22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: time for a standardized report scheme for pathologists","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(98)00050-3"},{"key":"2025121307531516000_67.8.1410.24","first-page":"371","article-title":"Comparison of the marsh-oberhuber classification with a new grading system in identifying patients with latent celiac disease","volume":"56","author":"Villanacci","year":"2010","journal-title":"Minerva Gastroenterol Dietol"},{"key":"2025121307531516000_67.8.1410.25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.5858\/134.6.826","article-title":"Gluten-sensitive enteropathy (celiac disease): controversies in diagnosis and classification","volume":"134","author":"Ensari","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"2025121307531516000_67.8.1410.26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076163","article-title":"Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease","volume":"8","author":"Taavela","year":"2013","journal-title":"PLoS One"},{"key":"2025121307531516000_67.8.1410.27","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.008"},{"key":"2025121307531516000_67.8.1410.28","doi-asserted-by":"crossref","first-page":"S603","DOI":"10.14309\/00000434-201210001-01509","article-title":"Celiac disease symptom frequency and severity using a disease-specific patient-reported outcome diary: observations from a psychometric validation study in 202 patients","volume":"107","author":"Adelman","year":"2012","journal-title":"Am J Gastro"},{"key":"2025121307531516000_67.8.1410.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04220.x"},{"key":"2025121307531516000_67.8.1410.30","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225516.05666.4e"},{"key":"2025121307531516000_67.8.1410.31","first-page":"1328e1","article-title":"A validated disease-specific symptom index for adults with celiac disease","volume":"7","author":"Leffler","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.32","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.54"},{"key":"2025121307531516000_67.8.1410.33","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925178"},{"key":"2025121307531516000_67.8.1410.34","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-945044"},{"key":"2025121307531516000_67.8.1410.35","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0486-5"},{"key":"2025121307531516000_67.8.1410.36","unstructured":"Oxford Centre for Evidence-based Medicine. Levels of evidence. Oxford: Oxford Centre for Evidence-based Medicine, 2009."},{"key":"2025121307531516000_67.8.1410.37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"2025121307531516000_67.8.1410.38","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"2025121307531516000_67.8.1410.39","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306578"},{"key":"2025121307531516000_67.8.1410.40","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"2025121307531516000_67.8.1410.41","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.023978"},{"key":"2025121307531516000_67.8.1410.42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/gastro\/gov006","article-title":"Development of drugs for celiac disease: review of endpoints for Phase 2 and 3 trials","volume":"3","author":"Gottlieb","year":"2015","journal-title":"Gastroenterol Rep"},{"key":"2025121307531516000_67.8.1410.43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cgh.2006.07.022","article-title":"Malabsorption work-up: utility of small bowel biopsy","volume":"4","author":"Babbin","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.44","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.gie.2014.10.024","article-title":"Endoscopic biopsy technique in the diagnosis of celiac disease: one bite or two?","volume":"81","author":"Latorre","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"2025121307531516000_67.8.1410.45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.prp.2012.01.008","article-title":"Tricks of the trade: how to avoid histological pitfalls in celiac disease","volume":"208","author":"Ravelli","year":"2012","journal-title":"Pathol Res Pract"},{"key":"2025121307531516000_67.8.1410.46","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314297"},{"key":"2025121307531516000_67.8.1410.47","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310007675"},{"key":"2025121307531516000_67.8.1410.48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07456.x"},{"key":"2025121307531516000_67.8.1410.49","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00428-013-1448-7","article-title":"Anti-TCR gamma antibody in celiac disease: the value of count on formalin-fixed paraffin-embedded biopsies","volume":"463","author":"Lonardi","year":"2013","journal-title":"Virchows Arch"},{"key":"2025121307531516000_67.8.1410.50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/nu8090525","article-title":"Persistent intraepithelial lymphocytosis in celiac patients adhering to gluten-free diet is not abolished despite a gluten contamination elimination diet","volume":"8","author":"Zanini","year":"2016","journal-title":"Nutrients"},{"key":"2025121307531516000_67.8.1410.51","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.024836"},{"key":"2025121307531516000_67.8.1410.52","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/MCG.0b013e3181b64557","article-title":"Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease","volume":"44","author":"Koskinen","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"2025121307531516000_67.8.1410.53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fmed.2014.00009","article-title":"Beyond the intestinal celiac mucosa: diagnostic role of anti-TG2 deposits, a systematic review","volume":"1","author":"Gatti","year":"2014","journal-title":"Front Med"},{"key":"2025121307531516000_67.8.1410.54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-230X-11-129","article-title":"Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease","volume":"11","author":"L\u00e4hdeaho","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"2025121307531516000_67.8.1410.55","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200372"},{"key":"2025121307531516000_67.8.1410.56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365521.2014.948052","article-title":"Weaknesses of histological analysis in celiac disease diagnosis: new possible scenarios","volume":"49","author":"Picarelli","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.57","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025121307531516000_67.8.1410.58","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"2025121307531516000_67.8.1410.59","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13249"},{"key":"2025121307531516000_67.8.1410.60","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.117986"},{"key":"2025121307531516000_67.8.1410.61","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/ajg.2015.285","article-title":"Are ESPGHAN \u201c biopsy-sparing\u201d guidelines for celiac disease also suitable for asymptomatic patients?","volume":"110","author":"Trovato","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.62","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000390"},{"key":"2025121307531516000_67.8.1410.63","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.276"},{"key":"2025121307531516000_67.8.1410.64","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31827a6f83"},{"key":"2025121307531516000_67.8.1410.65","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200605000-00006"},{"key":"2025121307531516000_67.8.1410.66","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31816200e5"},{"key":"2025121307531516000_67.8.1410.67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107811108"},{"key":"2025121307531516000_67.8.1410.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407457111"},{"key":"2025121307531516000_67.8.1410.69","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130696"},{"key":"2025121307531516000_67.8.1410.70","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182470249"},{"key":"2025121307531516000_67.8.1410.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.030"},{"key":"2025121307531516000_67.8.1410.72","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MCG.0000000000000105","article-title":"Titers of anti-tissue transglutaminase antibody correlate well with severity of villous abnormalities in celiac disease","volume":"49","author":"Singh","year":"2015","journal-title":"J Clin Gastroenterol"},{"key":"2025121307531516000_67.8.1410.73","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ajg.2015.155","article-title":"Predictors and significance of incomplete mucosal recovery in celiac disease after 1 year on a gluten-free diet","volume":"110","author":"Pekki","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.74","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.05.015","article-title":"Tests for serum transglutaminase and endomysial antibodies do not detect most patients with celiac disease and persistent villous atrophy on gluten-free diets: a meta-analysis","volume":"153","author":"Silvester","year":"2017","journal-title":"Gastroenterology"},{"key":"2025121307531516000_67.8.1410.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.10.012"},{"key":"2025121307531516000_67.8.1410.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.008"},{"key":"2025121307531516000_67.8.1410.77","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302196"},{"key":"2025121307531516000_67.8.1410.78","doi-asserted-by":"crossref","unstructured":"Sarna VK , Skodje GI , Reims HM , et al . HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge. Gut 2017:gutjnl-2017-314461.doi:10.1136\/gutjnl-2017-314461","DOI":"10.1136\/gutjnl-2017-314461"},{"key":"2025121307531516000_67.8.1410.79","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.100511"},{"key":"2025121307531516000_67.8.1410.80","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.025"},{"key":"2025121307531516000_67.8.1410.81","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35355"},{"key":"2025121307531516000_67.8.1410.82","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.91"},{"key":"2025121307531516000_67.8.1410.83","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.1.52"},{"key":"2025121307531516000_67.8.1410.84","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S2468-1253(17)30110-3","article-title":"Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies","volume":"2","author":"Goel","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.85","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12232"},{"key":"2025121307531516000_67.8.1410.86","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.humimm.2009.09.351","article-title":"Serum cytokine elevations in celiac disease: association with disease presentation","volume":"71","author":"Manavalan","year":"2010","journal-title":"Hum Immunol"},{"key":"2025121307531516000_67.8.1410.87","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.1.187"},{"key":"2025121307531516000_67.8.1410.88","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90047-7"},{"key":"2025121307531516000_67.8.1410.89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10050"},{"key":"2025121307531516000_67.8.1410.90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601693"},{"key":"2025121307531516000_67.8.1410.91","doi-asserted-by":"publisher","DOI":"10.1038\/73200"},{"key":"2025121307531516000_67.8.1410.92","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.059998"},{"key":"2025121307531516000_67.8.1410.93","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.4861"},{"key":"2025121307531516000_67.8.1410.94","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608610104"},{"key":"2025121307531516000_67.8.1410.95","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.23"},{"key":"2025121307531516000_67.8.1410.96","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614540154"},{"key":"2025121307531516000_67.8.1410.97","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/mi.2015.147","article-title":"TCR sequencing of single cells reactive to DQ2.5-glia-\u03b12 and DQ2.5-glia-\u03c92 reveals clonal expansion and epitope-specific V-gene usage","volume":"9","author":"Dahal-Koirala","year":"2016","journal-title":"Mucosal Immunol"},{"key":"2025121307531516000_67.8.1410.98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmgh.2017.01.011","article-title":"A B-cell gene signature correlates with the extent of gluten-induced intestinal injury in celiac disease","volume":"4","author":"Garber","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.99","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.031"},{"key":"2025121307531516000_67.8.1410.100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/nu9010046","article-title":"Biomarkers to monitor gluten-free diet compliance in celiac patients","volume":"9","author":"Moreno","year":"2017","journal-title":"Nutrients"},{"key":"2025121307531516000_67.8.1410.101","doi-asserted-by":"publisher","DOI":"10.1021\/pr050173t"},{"key":"2025121307531516000_67.8.1410.102","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074129"},{"key":"2025121307531516000_67.8.1410.103","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.026708"},{"key":"2025121307531516000_67.8.1410.104","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/ajg.2016.439","article-title":"Fecal gluten peptides reveal limitations of serological tests and food questionnaires for monitoring gluten-free diet in celiac disease patients","volume":"111","author":"Comino","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.105","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310148"},{"key":"2025121307531516000_67.8.1410.106","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1517\/14728222.2014.985207","article-title":"Transglutaminase as a therapeutic target for celiac disease","volume":"19","author":"Sulic","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"2025121307531516000_67.8.1410.107","unstructured":"Guidance for industry and FDA staff qualification process for drug development tools. US: U.S. Department of Health and Human Services FaDA, Center for Drug Evaluation and Research, 2014."},{"key":"2025121307531516000_67.8.1410.108","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.cgh.2016.05.009","article-title":"Personalized technologies in chronic gastrointestinal disorders: self-monitoring and remote sensor technologies","volume":"14","author":"Riaz","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025121307531516000_67.8.1410.109","unstructured":"Claims GfIP-ROMUiMPDtSL. US: U.S. Department of Health and Human Services FaDA, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research, Health CfDaR, 2009."},{"key":"2025121307531516000_67.8.1410.110","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12147"},{"key":"2025121307531516000_67.8.1410.111","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023002"},{"key":"2025121307531516000_67.8.1410.112","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1053\/j.gastro.2016.11.004","article-title":"No difference between latiglutenase and placebo in reducing\u00a0villous atrophy or improving symptoms in patients\u00a0with symptomatic celiac disease","volume":"152","author":"Murray","year":"2017","journal-title":"Gastroenterology"},{"key":"2025121307531516000_67.8.1410.113","doi-asserted-by":"crossref","first-page":"A595","DOI":"10.1016\/j.jval.2016.09.1429","article-title":"The Coeliac Disease Assessment Questionnaire (Cdaq): development of a patient-reported outcome measure","volume":"19","author":"Crocker","year":"2016","journal-title":"Value in Health"},{"key":"2025121307531516000_67.8.1410.114","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/apt.13372","article-title":"Randomised clinical study: gluten challenge induces symptom recurrence in only a minority of patients who meet clinical criteria for non-coeliac gluten sensitivity","volume":"42","author":"Zanini","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.115","first-page":"977","article-title":"Quality of life of adult coeliac patients treated for 10 years","volume":"33","author":"Hallert","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.116","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.003"},{"key":"2025121307531516000_67.8.1410.117","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535722"},{"key":"2025121307531516000_67.8.1410.118","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00431-011-1568-5","article-title":"Lane-Hamilton syndrome: case report and review of the literature","volume":"170","author":"Hendrickx","year":"2011","journal-title":"Eur J Pediatr"},{"key":"2025121307531516000_67.8.1410.119","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/apt.13725","article-title":"Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten-free diet","volume":"44","author":"Silvester","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.120","doi-asserted-by":"publisher","DOI":"10.3390\/nu5051585"},{"key":"2025121307531516000_67.8.1410.121","unstructured":"Crocker HPM , Jenkinson C . The Coeliac Disease Assessment Questionnaire (CDAQ). 2016."},{"key":"2025121307531516000_67.8.1410.122","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12262"},{"key":"2025121307531516000_67.8.1410.123","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/apt.13988","article-title":"Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten-free diet","volume":"45","author":"Mahadev","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.124","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.046"},{"key":"2025121307531516000_67.8.1410.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.027"},{"key":"2025121307531516000_67.8.1410.126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03992.x"},{"key":"2025121307531516000_67.8.1410.127","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/MCG.0000000000000433","article-title":"Quality of life in screen-detected celiac disease patients in the United States","volume":"50","author":"Mahadev","year":"2016","journal-title":"J Clin Gastroenterol"},{"key":"2025121307531516000_67.8.1410.128","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.05.011"},{"key":"2025121307531516000_67.8.1410.129","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clnu.2016.04.021","article-title":"Systematic review with meta-analysis: dietary adherence influences normalization of health-related quality of life in coeliac disease","volume":"36","author":"Burger","year":"2017","journal-title":"Clin Nutr"},{"key":"2025121307531516000_67.8.1410.130","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.04.019"},{"key":"2025121307531516000_67.8.1410.131","first-page":"105","article-title":"Gluten-free diet and quality of life in patients with screen-detected celiac disease","volume":"5","author":"Mustalahti","year":"2002","journal-title":"Eff Clin Pract"},{"key":"2025121307531516000_67.8.1410.132","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.10.011"},{"key":"2025121307531516000_67.8.1410.133","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200312000-00006"},{"key":"2025121307531516000_67.8.1410.134","doi-asserted-by":"publisher","DOI":"10.1080\/00365520119754"},{"key":"2025121307531516000_67.8.1410.135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MPG.0000000000000799","article-title":"Effects of gluten-free diet on quality of life and depression in children with celiac disease","volume":"61","author":"Simsek","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025121307531516000_67.8.1410.136","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"2025121307531516000_67.8.1410.137","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04972.x"},{"key":"2025121307531516000_67.8.1410.138","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.2"},{"key":"2025121307531516000_67.8.1410.139","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1858"},{"key":"2025121307531516000_67.8.1410.140","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3164"},{"key":"2025121307531516000_67.8.1410.141","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12809"},{"key":"2025121307531516000_67.8.1410.142","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/ajg.2015.434","article-title":"Neurological dysfunction in coeliac disease and non-coeliac gluten sensitivity","volume":"111","author":"Hadjivassiliou","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.143","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000133637.64414.20"},{"key":"2025121307531516000_67.8.1410.144","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i35.5837"},{"key":"2025121307531516000_67.8.1410.145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajcn\/85.1.160","article-title":"A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease","volume":"85","author":"Catassi","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"2025121307531516000_67.8.1410.146","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02908.x"},{"key":"2025121307531516000_67.8.1410.147","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.11.1515"},{"key":"2025121307531516000_67.8.1410.148","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.211"},{"key":"2025121307531516000_67.8.1410.149","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"key":"2025121307531516000_67.8.1410.150","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000004530.11738.a2"},{"key":"2025121307531516000_67.8.1410.151","first-page":"693","article-title":"Translation and validation of the gastrointestinal Quality of Life Index (GIQLI)","volume":"93","author":"Quintana","year":"2001","journal-title":"Rev Esp Enferm Dig"},{"key":"2025121307531516000_67.8.1410.152","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.46"},{"key":"2025121307531516000_67.8.1410.153","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0401_6"},{"key":"2025121307531516000_67.8.1410.154","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/SGA.0b013e318237d201","article-title":"The relationship between quality of life and coping strategies of adults with celiac disease adhering to a gluten-free diet","volume":"34","author":"Smith","year":"2011","journal-title":"Gastroenterol Nurs"},{"key":"2025121307531516000_67.8.1410.155","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.05.011"},{"key":"2025121307531516000_67.8.1410.156","doi-asserted-by":"crossref","unstructured":"Brooks RG , Rabin R , De Charro F . The measurement and valuation of health status using EQ-5D: a European perspective: evidence from the EuroQol BIOMED Research Programme. Dordrchet; Boston: Kluwer Academic Pub, 2003.","DOI":"10.1007\/978-94-017-0233-1"},{"key":"2025121307531516000_67.8.1410.157","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-105"},{"key":"2025121307531516000_67.8.1410.158","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-118"},{"key":"2025121307531516000_67.8.1410.159","first-page":"196","article-title":"Benefit on health-related quality of life of adherence to gluten-free diet in adult patients with celiac disease","volume":"107","author":"Casellas","year":"2015","journal-title":"Rev Esp Enferm Dig"},{"key":"2025121307531516000_67.8.1410.160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12876-015-0229-y","article-title":"Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease","volume":"15","author":"Ram\u00edrez-Cervantes","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"2025121307531516000_67.8.1410.161","unstructured":"Upton J . Beck Depression Inventory\u00a0(BDI). In: Gellman MD , Turner JR , eds. Encyclopedia of behavioral medicine. New York, NY: Springer New York, 2013:178\u20139."},{"key":"2025121307531516000_67.8.1410.162","first-page":"447","article-title":"Impact of gluten-free diet on quality of life in celiac patients","volume":"79","author":"Borghini","year":"2016","journal-title":"Acta Gastroenterol Belg"},{"key":"2025121307531516000_67.8.1410.163","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.03.004"},{"key":"2025121307531516000_67.8.1410.164","unstructured":"Dupuy H . et al The Psychological General Wellbeing (PGWB) Index. In: Wenger N , Mattson M , Furberg C , Elinson J , . eds. Assessment of quality of life in clinical trials of cardiovascular therapies:170\u201383."},{"key":"2025121307531516000_67.8.1410.165","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8287.2012.02069.x"},{"key":"2025121307531516000_67.8.1410.166","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/00365520310007783","article-title":"Effect of an oats-containing gluten-free diet on symptoms and quality of life in coeliac disease. A randomized study","volume":"39","author":"Per\u00e4aho","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"2025121307531516000_67.8.1410.167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02574.x"},{"key":"2025121307531516000_67.8.1410.168","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-75"},{"key":"2025121307531516000_67.8.1410.169","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"2025121307531516000_67.8.1410.170","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2036.2006.03227.x","article-title":"Predictors of reduced health-related quality of life in adults with coeliac disease","volume":"25","author":"H\u00e4user","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.171","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000221855.19201.e8"},{"key":"2025121307531516000_67.8.1410.172","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328342a547"},{"key":"2025121307531516000_67.8.1410.173","first-page":"241","article-title":"Quality of life in coeliac disease is determined by perceived degree of difficulty adhering to a gluten-free diet, not the level of dietary adherence ultimately achieved","volume":"20","author":"Barratt","year":"2011","journal-title":"J Gastrointestin Liver Dis"},{"key":"2025121307531516000_67.8.1410.174","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"2025121307531516000_67.8.1410.175","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12205"},{"key":"2025121307531516000_67.8.1410.176","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80087-1"},{"key":"2025121307531516000_67.8.1410.177","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.dld.2007.05.017","article-title":"Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients","volume":"39","author":"Usai","year":"2007","journal-title":"Dig Liver Dis"},{"key":"2025121307531516000_67.8.1410.178","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200412000-00008"},{"key":"2025121307531516000_67.8.1410.179","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283267941"},{"key":"2025121307531516000_67.8.1410.180","doi-asserted-by":"publisher","DOI":"10.1159\/000265549"},{"key":"2025121307531516000_67.8.1410.181","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0b013e3182248a73"},{"key":"2025121307531516000_67.8.1410.182","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.09.015"},{"key":"2025121307531516000_67.8.1410.183","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096346","article-title":"Validation of a French version of the quality of life \"celiac disease questionnaire\"","volume":"9","author":"Pouchot","year":"2014","journal-title":"PLoS One"},{"key":"2025121307531516000_67.8.1410.184","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.10.018"},{"key":"2025121307531516000_67.8.1410.185","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4321\/S1130-01082013001000003","article-title":"Transcultural adaptation and validation of the Celiac Disease Quality of Life (CD-QOL) Survey, a specific questionnaire to measure quality of life in patients with celiac disease","volume":"105","author":"Casellas","year":"2013","journal-title":"Rev Esp Enferm Dig"},{"key":"2025121307531516000_67.8.1410.186","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jhn.12319","article-title":"Coeliac disease: the association between quality of life and social support network participation","volume":"29","author":"Lee","year":"2016","journal-title":"J Hum Nutr Diet"},{"key":"2025121307531516000_67.8.1410.187","doi-asserted-by":"crossref","first-page":"181","DOI":"10.17235\/reed.2016.4094\/2015","article-title":"Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain","volume":"108","author":"Rodr\u00edguez Almagro","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"2025121307531516000_67.8.1410.188","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00394-015-1128-2","article-title":"A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet","volume":"56","author":"Russo","year":"2017","journal-title":"Eur J Nutr"},{"key":"2025121307531516000_67.8.1410.189","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0004-28032015000300003","article-title":"Quality of life evaluation in celiac patients from southern Brazil","volume":"52","author":"Castilhos","year":"2015","journal-title":"Arq Gastroenterol"},{"key":"2025121307531516000_67.8.1410.190","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.appet.2017.02.023","article-title":"Self-compassion directly and indirectly predicts dietary adherence and quality of life among adults with celiac disease","volume":"113","author":"Dowd","year":"2017","journal-title":"Appetite"},{"key":"2025121307531516000_67.8.1410.191","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.8.940"},{"key":"2025121307531516000_67.8.1410.192","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02619.x"},{"key":"2025121307531516000_67.8.1410.193","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"2025121307531516000_67.8.1410.194","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015295106602"},{"key":"2025121307531516000_67.8.1410.195","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/MCG.0b013e3181c41d12","article-title":"Fatigue as a determinant of health in patients with celiac disease","volume":"44","author":"Jord\u00e1","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"2025121307531516000_67.8.1410.196","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(82)90024-7"},{"key":"2025121307531516000_67.8.1410.197","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/469097"},{"key":"2025121307531516000_67.8.1410.198","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049163"},{"key":"2025121307531516000_67.8.1410.199","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(198321)2:2<15::AID-EAT2260020203>3.0.CO;2-6"},{"key":"2025121307531516000_67.8.1410.200","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/erv.2376","article-title":"Eating disorders in adolescents with celiac disease: influence of personality characteristics and coping","volume":"23","author":"Wagner","year":"2015","journal-title":"Eur Eat Disord Rev"},{"key":"2025121307531516000_67.8.1410.201","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.49.5.399"},{"key":"2025121307531516000_67.8.1410.202","unstructured":"Fairburn CG . Cognitive behavior therapy and eating disorders. New York, NY: Guilford Press, 2008."},{"key":"2025121307531516000_67.8.1410.203","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20504"},{"key":"2025121307531516000_67.8.1410.204","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"2025121307531516000_67.8.1410.205","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1365-2036.2010.04432.x","article-title":"The quality of sleep in patients with coeliac disease","volume":"32","author":"Zingone","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121307531516000_67.8.1410.206","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008848218806"},{"key":"2025121307531516000_67.8.1410.207","first-page":"357","article-title":"Short communication health-related quality of life measure for children-the TACQOL","volume":"1","author":"Kamphuis","year":"1997","journal-title":"J Appl Therapeut"},{"key":"2025121307531516000_67.8.1410.208","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111504"},{"key":"2025121307531516000_67.8.1410.209","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2221"},{"key":"2025121307531516000_67.8.1410.210","unstructured":"Koopman H , Theunissen N , Vogels A , et al . The DUC-25: a short-form questionnaire for measuring health related quality of life of children with a chronic illness. Quality of Life Research 1998:619\u201319."},{"key":"2025121307531516000_67.8.1410.211","first-page":"183","article-title":"The inventory of life quality in children and adolescents (ILC)","volume":"26","author":"Mattejat","year":"1998","journal-title":"Z Kinder-Jugendpsychiatrie"},{"key":"2025121307531516000_67.8.1410.212","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31817fcb56"},{"key":"2025121307531516000_67.8.1410.213","first-page":"66","article-title":"Berner fragebogen zum wohlbefinden jugendlicher (BFW)","volume":"37","author":"Grob","year":"1991","journal-title":"Diagnostica"},{"key":"2025121307531516000_67.8.1410.214","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199902000-00003"},{"key":"2025121307531516000_67.8.1410.215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1399-5448.2011.00785.x","article-title":"Quality of life in children with diabetes and celiac disease: minimal impact of the \u2019double diagnosis'","volume":"13","author":"Sud","year":"2012","journal-title":"Pediatr Diabetes"},{"key":"2025121307531516000_67.8.1410.216","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.07.009"},{"key":"2025121307531516000_67.8.1410.217","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jped.2016.06.012","article-title":"Psychopathology, quality of life, and related factors in children with celiac disease","volume":"93","author":"Sevin\u00e7","year":"2017","journal-title":"J Pediatr"},{"key":"2025121307531516000_67.8.1410.218","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798006667"},{"key":"2025121307531516000_67.8.1410.219","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9930-7"},{"key":"2025121307531516000_67.8.1410.220","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(97)82616-4"},{"key":"2025121307531516000_67.8.1410.221","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2011.011081"},{"key":"2025121307531516000_67.8.1410.222","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2458-13-142","article-title":"Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study","volume":"13","author":"Nordyke","year":"2013","journal-title":"BMC Public Health"},{"key":"2025121307531516000_67.8.1410.223","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-70"},{"key":"2025121307531516000_67.8.1410.224","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/986475","article-title":"Health-related quality of life in children and adolescents with celiac disease: from the perspectives of children and parents","volume":"2012","author":"Bystr\u00f6m","year":"2012","journal-title":"Gastroenterol Res Pract"},{"key":"2025121307531516000_67.8.1410.225","doi-asserted-by":"crossref","unstructured":"Turner-Bowker D , Hogue SJ . Short form 12 health survey (sf-12). Michalos AC , ed. Encyclopedia of quality of life and well-being research. Dordrecht: Springer Netherlands, 2014:5954\u20137.","DOI":"10.1007\/978-94-007-0753-5_2698"},{"key":"2025121307531516000_67.8.1410.226","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-204"},{"key":"2025121307531516000_67.8.1410.227","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1469-8749.1995.tb15015.x","article-title":"The quality of life of children with chronic epilepsy and their families: preliminary findings with a new assessment measure","volume":"37","author":"Hoare","year":"1995","journal-title":"Dev Med Child Neurol"},{"key":"2025121307531516000_67.8.1410.228","first-page":"599","article-title":"The quality of life in developing age children with celiac disease","volume":"65","author":"Di Filippo","year":"2013","journal-title":"Minerva Pediatr"},{"key":"2025121307531516000_67.8.1410.229","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.5.3.353"},{"key":"2025121307531516000_67.8.1410.230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/1471-2458-14-425","article-title":"Health-related quality of life is not impaired in children with undetected as well as diagnosed celiac disease: a large population based cross-sectional study","volume":"14","author":"Myl\u00e9us","year":"2014","journal-title":"BMC Public Health"},{"key":"2025121307531516000_67.8.1410.231","first-page":"995","article-title":"The Children\u2019s Depression, Inventory (CDI)","volume":"21","author":"Kovacs","year":"1985","journal-title":"Psychopharmacol Bull"},{"key":"2025121307531516000_67.8.1410.232","first-page":"409","article-title":"[The psychometric properties of the new Turkish generic health-related quality of life questionnaire for children (Kid-KINDL)]","volume":"19","author":"Eser","year":"2008","journal-title":"Turk Psikiyatri Derg"},{"key":"2025121307531516000_67.8.1410.233","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31815ef87d"},{"key":"2025121307531516000_67.8.1410.234","first-page":"19","article-title":"Implementation of a health-related quality of life questionnaire for children and adolescents with celiac disease","volume":"112","author":"Pico","year":"2014","journal-title":"Arch Argent Pediatr"},{"key":"2025121307531516000_67.8.1410.235","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/MPG.0000000000000963","article-title":"Health-related quality of life in spanish children with coeliac disease","volume":"62","author":"Torres","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025121307531516000_67.8.1410.236","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jped.2014.11.005","article-title":"Translation, cultural adaptation, and validation of the celiac disease DUX (CDDUX)","volume":"91","author":"Lins","year":"2015","journal-title":"J Pediatr"},{"key":"2025121307531516000_67.8.1410.237","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/MPG.0000000000001355","article-title":"Comparison of patients\u2019 and doctors\u2019reports on health-related quality of life in celiac disease","volume":"64","author":"Vriezinga","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025121307531516000_67.8.1410.238","doi-asserted-by":"crossref","first-page":"7006220010p1","DOI":"10.5014\/ajot.2016.020594","article-title":"Children with celiac disease: health-related quality of life and leisure participation","volume":"70","author":"Meyer","year":"2016","journal-title":"Am J Occup Ther"},{"key":"2025121307531516000_67.8.1410.239","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31829b68a1"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gutjnl-2017-314853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T15:53:37Z","timestamp":1765641217000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gutjnl-2017-314853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":239,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,7,9]]},"published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1136\/gutjnl-2017-314853"],"URL":"https:\/\/doi.org\/10.1136\/gutjnl-2017-314853","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,13]]}}}