{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:48:09Z","timestamp":1794264489502,"version":"4.9.0"},"reference-count":38,"publisher":"BMJ","issue":"3","funder":[{"DOI":"10.13039\/100011100","name":"Minist\u00e8re du D\u00e9veloppement \u00c9conomique, de l\u2019Innovation et de l\u2019Exportation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000035","name":"Institute of Nutrition, Metabolism and Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2018,7,12]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu (\n                      <jats:italic>Myrciaria dubia<\/jats:italic>\n                      ) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal microbial transplantation (FMT), we have assessed the effect of a crude extract of camu camu (CC) on obesity and associated immunometabolic disorders in high fat\/high sucrose (HFHS)-fed mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment of HFHS-fed mice with CC prevented weight gain, lowered fat accumulation and blunted metabolic inflammation and endotoxaemia. CC-treated mice displayed improved glucose tolerance and insulin sensitivity and were also fully protected against hepatic steatosis. These effects were linked to increased energy expenditure and upregulation of uncoupling protein 1 mRNA expression in the brown adipose tissue (BAT) of CC-treated mice, which strongly correlated with the mRNA expression of the membrane bile acid (BA) receptor TGR5. Moreover, CC-treated mice showed altered plasma BA pool size and composition and drastic changes in the GM (eg, bloom of\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                      and a strong reduction of\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      ). Germ-free (GF) mice reconstituted with the GM of CC-treated mice gained less weight and displayed higher energy expenditure than GF-mice colonised with the FM of HFHS controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results show that CC prevents visceral and liver fat deposition through BAT activation and increased energy expenditure, a mechanism that is dependent on the GM and linked to major changes in the BA pool size and composition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2017-315565","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T05:15:23Z","timestamp":1533014123000},"page":"453-464","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":245,"title":["Treatment with camu camu (\n                    <i>Myrciaria dubia<\/i>\n                    ) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice"],"prefix":"10.1136","volume":"68","author":[{"given":"Fernando F","family":"Anh\u00ea","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Cardiology Axis of the Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec, Canada"},{"name":"Institute of Nutrition and Functional Foods, Laval University, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato T","family":"Nachbar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Cardiology Axis of the Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault V","family":"Varin","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods, Laval 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Feutry","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods, Laval University, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Pilon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Cardiology Axis of the Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec, Canada"},{"name":"Institute of Nutrition and Functional Foods, Laval University, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Barbier","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Endocrinology-Nephrology Axis, CHU-Qu\u00e9bec Research Centre, Qu\u00e9bec, Canada"},{"name":"Faculty of Pharmacy, Laval University, Qu\u00e9bec, 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