{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:06:20Z","timestamp":1792757180033,"version":"4.5.0"},"reference-count":55,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/100015677","name":"Medical Psychiatry Alliance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015677","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2018,12,8]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with inflammatory bowel disease (IBD) have an elevated risk of mental illness. We determined the incidence and correlates of new-onset mental illness associated with IBD during pregnancy and post partum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This cohort study using population-based health administrative data included all women with a singleton live birth in Ontario, Canada (2002\u20132014). The incidence of new-onset mental illness from conception to 1-year post partum was compared between 3721 women with and 798\u2009908 without IBD, generating adjusted HRs (aHR). Logistic regression was used to identify correlates of new-onset mental illness in the IBD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>About 22.7% of women with IBD had new-onset mental illness versus 20.4% without, corresponding to incidence rates of 150.2 and 132.8 per 1000 patient-years (aHR 1.12, 95%\u2009CI 1.05 to 1.20), or one extra case of new-onset mental illness per 43 pregnant women with IBD. The risk was elevated in the post partum (aHR 1.20, 95%\u2009CI 1.09 to 1.31), but not during pregnancy, and for Crohn\u2019s disease (aHR 1.12, 95%\u2009CI 1.02 to 1.23), but not ulcerative colitis. The risk was specifically elevated for a new-onset mood or anxiety disorder (aHR 1.14, 95%\u2009CI 1.04 to 1.26) and alcohol or substance use disorders (aHR 2.73, 95%\u2009CI 1.42 to 5.26). Predictors of a mental illness diagnosis were maternal age, delivery year, medical comorbidity, number of prenatal visits, family physician obstetrical care and infant mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with IBD were at an increased risk of new-onset psychiatric diagnosis in the postpartum period, but not during pregnancy. Providers should look to increase opportunities for prevention, early identification and treatment accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gutjnl-2018-317610","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T05:25:12Z","timestamp":1547097912000},"page":"1597-1605","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Inflammatory bowel disease and new-onset psychiatric disorders in pregnancy and post partum: a population-based cohort study"],"prefix":"10.1136","volume":"68","author":[{"given":"Simone N","family":"Vigod","sequence":"first","affiliation":[{"name":"Women\u2019s College Hospital and Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada"},{"name":"ICES, 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