{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:36:04Z","timestamp":1790922964812,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Gut"],"accepted":{"date-parts":[[2026,1,13]]},"DOI":"10.1136\/gutjnl-2025-337652","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:20:27Z","timestamp":1769538027000},"page":"gutjnl-2025-337652","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Kupffer cell autophagy emerges as a central regulator of immune dysregulation in primary biliary cholangitis"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-0872","authenticated-orcid":false,"given":"Naths Grazia","family":"Sukubo","sequence":"first","affiliation":[{"name":"Medicine and Surgery, University of Milan-Bicocca, Monza, Italy"},{"name":"Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2330-3230","authenticated-orcid":false,"given":"Chiara","family":"Caime","sequence":"additional","affiliation":[{"name":"Medicine and Surgery, University of Milan-Bicocca, Monza, Italy"},{"name":"Gastroenterology, IRCCS San Gerardo dei Tintori Foundation Hospital, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gerussi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Lombardy, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3262-1998","authenticated-orcid":false,"given":"Pietro","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Program for Autoimmune Liver Diseases, International Center for Digestive Diseases, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026012710202146000_gutjnl-2025-337652v1.1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jaut.2018.10.015","article-title":"The immunobiology of female predominance in primary biliary cholangitis","volume":"95","author":"Gerussi","year":"2018","journal-title":"J Autoimmun"},{"key":"2026012710202146000_gutjnl-2025-337652v1.2","doi-asserted-by":"crossref","first-page":"1241901","DOI":"10.3389\/fgstr.2023.1241901","article-title":"Current and future opportunities for the management of primary biliary cholangitis","volume":"2","author":"Naffouj","year":"2023","journal-title":"Front Gastroenterol"},{"key":"2026012710202146000_gutjnl-2025-337652v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.51"},{"key":"2026012710202146000_gutjnl-2025-337652v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28359"},{"key":"2026012710202146000_gutjnl-2025-337652v1.5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.intimp.2019.02.016","article-title":"The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice","volume":"70","author":"Qu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"2026012710202146000_gutjnl-2025-337652v1.6","doi-asserted-by":"crossref","unstructured":"Jin C , Jiang P , Zhang Z , et al . Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis. Nat Commun 2024;15. doi:10.1038\/s41467-024-53104-9","DOI":"10.1038\/s41467-024-53104-9"},{"key":"2026012710202146000_gutjnl-2025-337652v1.7","doi-asserted-by":"crossref","unstructured":"Luo P-Y , Ma M , Liu M-C , et al . Autophagy of Kupffer cells modulates CD8 + T cell activation in primary biliary cholangitis. Gut 2025. doi:10.1136\/gutjnl-2025-335611","DOI":"10.1136\/gutjnl-2025-335611"},{"key":"2026012710202146000_gutjnl-2025-337652v1.8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1655"},{"key":"2026012710202146000_gutjnl-2025-337652v1.9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1152\/physrev.00004.2023","article-title":"The liver as a central \u201chub\u201d of the immune system: pathophysiological implications","volume":"105","author":"Ronca","year":"2025","journal-title":"Physiol Rev"},{"key":"2026012710202146000_gutjnl-2025-337652v1.10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3762\/bjnano.16.10","article-title":"Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy","volume":"16","author":"Sukubo","year":"2025","journal-title":"Beilstein J Nanotechnol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gutjnl-2025-337652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:20:28Z","timestamp":1769538028000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gutjnl-2025-337652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":10,"alternative-id":["10.1136\/gutjnl-2025-337652"],"URL":"https:\/\/doi.org\/10.1136\/gutjnl-2025-337652","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}