{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:21:59Z","timestamp":1762377719743,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart Asia"],"accepted":{"date-parts":[[2010,9,15]]},"published-print":{"date-parts":[[2010]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess prevalence, in-hospital prognostic significance and angiographic correlation of C-reactive protein (CRP) elevation in patients with unstable angina.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Royal Hospital, Muscat, Oman.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>100 patients admitted between July 2008 and January 2009.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Patients with unstable angina and ECG changes without biochemical evidence of necrosis (negative first troponin T), had CRP measured at admission by rate nephelometry (\u226510\u2005mg\/l abnormal).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>In-hospital cardiac events and severity of coronary artery disease (CAD) in patients with and without CRP elevation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>42% had CRP elevation \u226510\u2005mg\/l (Group I), and 58% had levels &lt;10\u2005mg\/l (Group II). When compared with Group II, Group I patients had more anginal episodes (mean=4.6\u00b12.5 episodes\/patient vs 1.6\u00b12.4; p&lt;0.0001), myocardial infarction (58% vs 17%; p&lt;0.01), in-hospital mortality (9% vs 0%; p=0.03) and severe triple vessel disease (71% vs 24%; p&lt;0.01), and a higher total number of events (86% vs 24%; p&lt;0.0001). Elevated admission CRP as a marker of in-hospital cardiac events showed a sensitivity of 72%, specificity of 88% and positive predictive value of 85%, and, as a marker of significant CAD, showed a specificity of 83% and a positive predictive value of 85%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Raised admission CRP level is predictive of increased in-hospital cardiac events and severe CAD in patients with unstable angina. CRP can be used to risk-stratify unstable angina patients independent of troponin levels. Patients with abnormal CRP should undergo coronary angiography either on-site or transferred to a centre with catheterisation facility during the index hospital admission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/ha.2009.001297","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T17:02:12Z","timestamp":1756054932000},"page":"140-144","source":"Crossref","is-referenced-by-count":1,"title":["C-reactive protein in unstable angina: clinical and angiographic correlation"],"prefix":"10.1136","volume":"2","author":[{"given":"Prashanth","family":"Panduranga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulla A","family":"Riyami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadhim 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