{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:31:04Z","timestamp":1787729464597,"version":"build-2784847793"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,7,19]]},"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To describe the mode of presentation and the clinical course of patients with ventricular pre-excitation (Wolff-Parkinson-White (WPW) syndrome), with special emphasis on asymptomatic cases in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Over an eight year period (1990\u201397) a prospective population based survey of cases with WPW pattern was conducted in a defined population in north west Greece (340\u2009000 inhabitants). ECGs with WPW pattern were obtained from a widespread pool of ECGs within the health system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      During the study period, 157 cases with WPW pattern were identified (49 female, 108 male). Ages ranged from infants to 84 years, mean (SD) 49.1 (21.0) years in female and 39.6 (20.6) years in male subjects (p\u2009&lt;\u20090.01); 78 (49%) had no history of syndrome related symptoms. Asymptomatic subjects (n\u2009=\u200977; 24 female, 53 male) were older than symptomatic subjects (mean age 46.7 (21.0)\n                      <jats:italic>v<\/jats:italic>\n                      38.5 (20.6) years, p\u2009&lt;\u20090.03). Documented supraventricular tachycardia was recorded in 27 patients (17%) and atrial fibrillation in 12 (8%) (mean age at first episode 31.2 (18.3) and 51.6 (20.7) years, respectively, p\u2009&lt;\u20090.01). During follow up (mean 55 months) no case of sudden death occurred. Three asymptomatic subjects reported episodes of brief palpitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>WPW pattern is more common, and diagnosed at a younger age, in men than in women. About half the patients with WPW pattern on ECG are asymptomatic at diagnosis and tend to remain so thereafter. No sudden cardiac death occurred during the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heart.83.1.29","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"29-34","source":"Crossref","is-referenced-by-count":94,"title":["Ventricular pre-excitation in the general population: a study on the mode of presentation and clinical course"],"prefix":"10.1136","volume":"83","author":[{"given":"J A","family":"Goudevenos","sequence":"first","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Katsouras","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Graekas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Argiri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Giogiakas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Sideris","sequence":"additional","affiliation":[{"name":"Division of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"2025091922502658000_83.1.29.1","unstructured":"Wellens HJJ Brugada P Penn OC (1990) Pre-excitation syndromes: clinical presentation, course and therapy. in Cardiac electrophysiology: from cell to bedside. eds Zipes DP Jalife J (WB Saunders, Philadelphia), pp 691\u2013702."},{"key":"2025091922502658000_83.1.29.2","unstructured":"Josephson M (1993) Preexcitation syndromes. in Clinical cardiac electrophysiology. ed Josephson M (Lea & Febiger, Philadelphia), pp 311\u2013416."},{"key":"2025091922502658000_83.1.29.3","first-page":"474","article-title":"Prevalence and course of Wolff-Parkinson-White syndrome in population of 138,048 subjects.","volume":"136","author":"Guize","year":"1985","journal-title":"Ann Med Interne (Paris)"},{"key":"2025091922502658000_83.1.29.4","unstructured":"Wellens HJJ Fare J Bar FW (1987) The Wolff-Parkinson-White syndrome. in Cardiac arrhythmias. 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