{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:11:45Z","timestamp":1787242305148,"version":"build-2736575974"},"reference-count":17,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,10,11]]},"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess whether long term treatment with epoprostenol might restore primary non-responsiveness to nitric oxide (NO) in patients with primary pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Seven patients with primary pulmonary hypertension receiving intravenous epoprostenol continuously because of failure of NO to influence pulmonary haemodynamics during initial testing were followed over a period of 13\u201329 months. Afterwards, acute vascular reactivity towards NO was tested again during right heart catheterisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Administration of NO after continuous epoprostenol treatment for a mean period of 18 months improved arterial oxygen saturation (p\u2009&lt;\u20090.01) and cardiac index (p\u2009&lt;\u20090.05), and decreased mean pulmonary artery pressure (p\u2009&lt;\u20090.01) and total pulmonary vascular resistance (p\u2009&lt;\u20090.01) in patients previously unresponsive to NO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Long term treatment with epoprostenol reverts initial refractoriness to NO in patients with primary pulmonary hypertension. Thus the addition of NO to epoprostenol treatment might cause further improvement in the course of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heart.83.4.406","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"406-409","source":"Crossref","is-referenced-by-count":13,"title":["Treatment with epoprostenol reverts nitric oxide non-responsiveness in patients with primary pulmonary hypertension"],"prefix":"10.1136","volume":"83","author":[{"given":"R","family":"Ziesche","sequence":"first","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Petkov","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Wittmann","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kopatschka","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Stiebellehner","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Schenk","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Germann","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"R\u00f6der","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ullrich","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Block","sequence":"additional","affiliation":[{"name":"aDepartment of Internal Medicine IV, University of Vienna Medical School, W\u00e4hringer G\u00fcrtel 18-20, A-1090 Vienna, Austria, \n\nbDepartment of Anesthesiology and General Intensive Care, University of Vienna Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2025100706135619000_83.4.406.1","unstructured":"Rubin LJ Rich S , eds (1997) Pathophysiology of primary pulmonary hypertension. 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