{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:10:08Z","timestamp":1777356608094,"version":"3.51.4"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2000,4,25]]},"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To evaluate the effect of nurse initiated thrombolysis on door to needle time (the interval between arriving at the hospital and starting thrombolytic treatment) in patients with acute myocardial infarction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>Comparison of door to needle times before and after the employment of nurses trained and approved to initiate thrombolysis without prescription by a doctor but with a protocol for rapid triage of patients with chest pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>A district general hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUBJECTS<\/jats:title>\n                  <jats:p>All patients admitted with suspected myocardial infarction between April 1995 and March 1999.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                  <jats:p>Speed (door to needle time) and appropriateness of administration of thrombolytic drugs to patients with acute myocardial infarction who gave a characteristic history and had appropriate criteria on the admission ECG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>During seven periods (each of four months) before the introduction of nurse initiated thrombolysis and a new chest pain triage protocol, the median door to needle time varied from 50\u201358 minutes. In four periods (each of 4\u20136 months) following the introduction of the changes, the median door to needle time was 25\u201330 minutes. The improvement was significant (p\u2009&lt;\u20090.001). Nurses trained to initiate thrombolysis currently provide cover for 66% of the time. Median door to needle time for nurses was 15 minutes. Median door to needle time for junior doctors improved to 35 minutes. The median door to needle times when nurses initiated thrombolysis was significantly shorter than when doctors did so (p\u2009&lt;\u20090.001). There have been no inappropriate management decisions by nurses approved to initiate thrombolysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The use of nurse initiated thrombolysis has resulted in a clinically important reduction in the time taken for thrombolysis to be started in patients with acute myocardial infarction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.84.3.262","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"262-266","source":"Crossref","is-referenced-by-count":42,"title":["Improving door to needle times with nurse initiated thrombolysis"],"prefix":"10.1136","volume":"84","author":[{"given":"P","family":"Wilmshurst","sequence":"first","affiliation":[{"name":"aDepartment of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK, \n\nbDepartment of Clinical Audit, \n\ncNHS Executive West Midlands, Department of Health, Birmingham B15 3DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Purchase","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK, \n\nbDepartment of Clinical Audit, \n\ncNHS Executive West Midlands, Department of Health, Birmingham B15 3DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Webb","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK, \n\nbDepartment of Clinical Audit, \n\ncNHS Executive West Midlands, Department of Health, Birmingham B15 3DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Jowett","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK, \n\nbDepartment of Clinical Audit, \n\ncNHS Executive West Midlands, Department of Health, Birmingham B15 3DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Quinn","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK, \n\nbDepartment of Clinical Audit, \n\ncNHS Executive West Midlands, Department of Health, Birmingham B15 3DP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025092003322851000_84.3.262.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91344-7"},{"key":"2025092003322851000_84.3.262.2","first-page":"312","article-title":"The management of acute myocardial infarction: guidelines and audit standards.","volume":"28","author":"De Bono","year":"1994","journal-title":"J R Coll Physicians Lond"},{"key":"2025092003322851000_84.3.262.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-3397(98)80614-9"},{"key":"2025092003322851000_84.3.262.4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.304.6819.83","article-title":"Effect of \u201cfast track\u201d admission for acute myocardial infarction on delay to thrombolysis.","volume":"304","author":"Pell","year":"1992","journal-title":"BMJ"},{"key":"2025092003322851000_84.3.262.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-3397(95)80605-9"},{"key":"2025092003322851000_84.3.262.6","first-page":"136","article-title":"The advanced nurse practitioner in CCU.","volume":"12","author":"Caunt","year":"1996","journal-title":"Care Crit Ill"},{"key":"2025092003322851000_84.3.262.7","unstructured":"NHS Executive (1999) Quality and performance in the NHS: clinical indicators. (Department of Health, London)."},{"key":"2025092003322851000_84.3.262.8","first-page":"46","article-title":"Effectiveness of a \u201cthrombolysis nurse\u201d in shortening delay to thrombolysis in acute myocardial infarction.","volume":"33","author":"Somauroo","year":"1999","journal-title":"J R Coll Physicians Lond"},{"key":"2025092003322851000_84.3.262.9","first-page":"284","article-title":"What is meant by \u201cthrombolysis nurse\u201d? [letter]","volume":"33","author":"Wilmshurst","year":"1999","journal-title":"J R Coll Physicians Lond"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.84.3.262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T10:32:35Z","timestamp":1758364355000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.84.3.262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,9,1]]},"published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["10.1136\/heart.84.3.262"],"URL":"https:\/\/doi.org\/10.1136\/heart.84.3.262","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]}}}