{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:15:02Z","timestamp":1786540502810,"version":"build-2736575974"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2000,5,10]]},"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Postoperative pulmonary hypertension in children after congenital heart surgery is a risk factor for death and is associated with severe acute changes in both pulmonary vascular resistance and lung mechanics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To examine the impact of changes in pulmonary blood flow on lung mechanics in preoperative children with congenital heart disease, in order to assess the cause\u2013effect relation of pulmonary vascular\u2013bronchial interactions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>Prospective, cross sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>Cardiac catheterisation laboratory, general anaesthesia with mechanical ventilation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>INTERVENTIONS<\/jats:title>\n                  <jats:p>Variation of pulmonary blood flow (Qp) by either balloon occlusion of an atrial septal defect before interventional closure, or by complete occlusion of the pulmonary artery during balloon pulmonary valvuloplasty for pulmonary valve stenosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                  <jats:p>Ventilatory tidal volume (Vt), dynamic respiratory system compliance (Cdyn), respiratory system resistance (Rrs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>28 occlusions were examined in nine patients with atrial septal defect (median age 9.5 years) and 22 in eight patients with pulmonary stenosis (median age 1.2 years). Normalisation of Qp during balloon occlusion of atrial septal defect caused no significant change in airway pressures and Rrs, but there was a small decrease in Vt (mean (SD): 9.61 (0.85) to 9.52 (0.97)\u2009ml\/kg; p\u2009&lt;\u20090.05) and Cdyn (0.64 (0.11) to 0.59 (0.10)\u2009ml\/cm\u2009H<jats:sub>2<\/jats:sub>O*kg; p\u2009&lt;\u20090.01). These changes were more pronounced when there was complete cessation of Qp during balloon valvuloplasty in pulmonary stenosis, with a fall in Vt (9.71 (2.95) to 9.32 (2.84)\u2009ml\/kg; p\u2009&lt;\u20090.05) and Cdyn (0.72 (0.29) to 0.64 (0.26)\u2009ml\/cm\u2009H<jats:sub>2<\/jats:sub>O*kg; p\u2009&lt;\u20090.001), and there was also an increase in Rrs (25.1 (1.7) to 28.8 (1.6)\u2009cm\u2009H<jats:sub>2<\/jats:sub>O\/litre*s; p\u2009&lt;\u20090.01). All these changes exceeded the variability of the baseline measurements more than threefold.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Acute changes in pulmonary blood flow are associated with simultaneous changes in lung mechanics. While these changes are small they may represent a valid model to explain the pathophysiological impact of spontaneous changes in pulmonary blood flow in clinically more critical situations in children with congenital heart disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.84.3.284","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"284-289","source":"Crossref","is-referenced-by-count":15,"title":["Pulmonary vascular\u2013bronchial interactions: acute reduction in pulmonary blood flow alters lung mechanics"],"prefix":"10.1136","volume":"84","author":[{"given":"I","family":"Schulze-Neick","sequence":"first","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Penny","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Derrick","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Dhillon","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Rigby","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kelleher","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bush","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Redington","sequence":"additional","affiliation":[{"name":"aCardiothoracic Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1 3JN, UK, \n\nbDepartment of Paediatrics, The Royal Brompton and Harefield NHS Trust, Sydney Street, London SW3 6NP, UK, \n\ncDepartment of Anaesthesiology, The Royal Brompton and Harefield NHS Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025092006210357000_84.3.284.1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-5223(19)34676-8","article-title":"Does Down syndrome affect prognosis of surgically managed atrioventricular canal defects? 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