{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:22:21Z","timestamp":1790878941784,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2000,9,4]]},"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To assess whether the concentrations of serum advanced glycation end products (AGE) in diabetic patients with obstructive coronary artery disease differ from those in type 2 diabetic patients without obstructive coronary artery disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>Serum AGE concentrations were measured in type 2 diabetic patients and in non-diabetic patients, both with and without obstructive coronary artery disease, and the relation between these values and coronary disease severity was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Mean (SD) serum AGE concentrations were higher (p\u2009&lt;\u20090.0125) in type 2 diabetic patients with obstructive coronary artery disease (5.5 (2.5)\u2009mU\/ml, n\u2009=\u200930) than in patients without obstructive coronary artery disease (2.8 (0.5)\u2009mU\/ml, n\u2009=\u200912), and higher than in non-diabetic patients with (3.4 (1.0)\u2009mU\/ml, n\u2009=\u200928) and without (3.2 (0.4)\u2009mU\/ml, n\u2009=\u200913) obstructive coronary artery disease. Serum AGE was associated with the degree of coronary arteriosclerosis in type 2 diabetic patients with obstructive coronary artery disease (single vessel: n\u2009=\u200913, 3.4 (0.9)\u2009mU\/m; two vessel: n\u2009=\u20096, 5.7 (1.6)\u2009mU\/m; three vessel: n\u2009=\u200911, 7.2 (2.5)\u2009mU\/ml). Serum AGE was positively correlated with serum mean four year HbA<jats:sub>1C<\/jats:sub>(<jats:italic>r<\/jats:italic>\u2009=\u20090.46, p\u2009&lt;\u20090.01), but not with recent serum HbA<jats:sub>1C<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u20090.24). The four groups did not differ in the other coronary risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Serum AGE concentrations may be associated with long term poor glycaemic control and reflect the severity of coronary arteriosclerosis in type 2 diabetic patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.85.1.87","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"87-91","source":"Crossref","is-referenced-by-count":92,"title":["Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients"],"prefix":"10.1136","volume":"85","author":[{"given":"K","family":"Kiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025101714551549000_85.1.87.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805193182007"},{"key":"2025101714551549000_85.1.87.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109193251202"},{"key":"2025101714551549000_85.1.87.3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2337\/diacare.21.6.1027a","article-title":"Increased serum levels of advanced glycation end products in NIDDM patients with diabetic complications.","volume":"21","author":"Ono","year":"1998","journal-title":"Diabetes Care"},{"key":"2025101714551549000_85.1.87.4","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.1.54"},{"key":"2025101714551549000_85.1.87.5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92372-3"},{"key":"2025101714551549000_85.1.87.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90010-X"},{"key":"2025101714551549000_85.1.87.7","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1016\/S0021-9258(18)42741-X","article-title":"Immunochemical detection of advanced glycosylation end products in vivo.","volume":"267","author":"Makita","year":"1992","journal-title":"J Biol Chem"},{"key":"2025101714551549000_85.1.87.8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0021-9258(18)74360-3","article-title":"A rapid photoelectric method for the determination of glucose in blood and urine.","volume":"120","author":"Hoffman","year":"1937","journal-title":"J Biol Chem"},{"key":"2025101714551549000_85.1.87.9","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/clinchem\/19.12.1350","article-title":"Preparation and properties of a cholesterol oxidase from Nacardia sp and its application to the enzymatic assay of total cholesterol in serum.","volume":"19","author":"Richmond","year":"1973","journal-title":"Clin Chem"},{"key":"2025101714551549000_85.1.87.10","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(68)90041-7"},{"key":"2025101714551549000_85.1.87.11","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0022-2275(20)38059-7","article-title":"Separation and quantitation of subclasses of human plasma high density lipoproteins by a single precipitation procedure.","volume":"23","author":"Didez","year":"1982","journal-title":"J Lipid Res"},{"key":"2025101714551549000_85.1.87.12","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"2025101714551549000_85.1.87.13","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1543"},{"key":"2025101714551549000_85.1.87.14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1172\/JCI115014","article-title":"Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.","volume":"87","author":"Bucala","year":"1991","journal-title":"J Clin Invest"},{"key":"2025101714551549000_85.1.87.15","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.9.1481"},{"key":"2025101714551549000_85.1.87.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.9010"},{"key":"2025101714551549000_85.1.87.17","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.308"},{"key":"2025101714551549000_85.1.87.18","first-page":"207","article-title":"Deposition of advanced glycation end products (AGE) and expression of the receptor for AGE in cardiovascular tissue of the diabetic rat.","volume":"79","author":"Sun","year":"1998","journal-title":"Int J Exp Pathol"},{"key":"2025101714551549000_85.1.87.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.14.6434"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.85.1.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:55:22Z","timestamp":1760738122000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.85.1.87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,1,1]]},"published-print":{"date-parts":[[2001,1,1]]}},"alternative-id":["10.1136\/heart.85.1.87"],"URL":"https:\/\/doi.org\/10.1136\/heart.85.1.87","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,1]]}}}