{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:18:13Z","timestamp":1771643893507,"version":"3.50.1"},"reference-count":20,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2000,11,21]]},"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine the relation between psychological characteristics and subsequent fatal ischaemic heart disease (IHD) events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>Prospective study of participants in the Northwick Park heart study (NPHS) recruited between 1972 and 1978 and followed up for fatal events until 1997.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>Three occupational groups in north west London.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUBJECTS<\/jats:title>\n                  <jats:p>1408 white men without a history of myocardial infarction aged 40\u201364 years at entry who completed a Crown-Crisp experiential index form (CCEI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURE<\/jats:title>\n                  <jats:p>Fatal IHD during follow up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A one point increase in the score on the obsessionality\/obsessional neurosis subscale was associated with a relative risk of fatal IHD of 1.08 (95% confidence interval (CI) 1.02 to 1.15). For the functional somatic complaint subscale the relative risk was also 1.08 (95% CI 1.02 to 1.15). In the case of the total score the relative risk of fatal IHD was 1.28 (95% CI 1.09 to 1.50) for a 10 point increase. The associations were independent of age, social class, and known cardiovascular risk factors. In the case of phobic anxiety, which had previously been found to be associated with fatal IHD in NPHS, the association was evident in the first 10 years of follow up but overall the relative risk was only 1.07 (95% CI 0.99 to 1.15) for a one point increase in the score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Scores on two of the subscales of the CCEI and the total score are significantly associated with fatal IHD on long term follow up independently of other known risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.85.4.385","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"385-389","source":"Crossref","is-referenced-by-count":35,"title":["Psychological characteristics and fatal ischaemic heart disease"],"prefix":"10.1136","volume":"85","author":[{"given":"A","family":"Haines","sequence":"first","affiliation":[{"name":"aDepartment of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK, \n\nbMRC Epidemiology and Medical Care Unit, St Bartholomew's and the Royal London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Cooper","sequence":"additional","affiliation":[{"name":"aDepartment of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK, \n\nbMRC Epidemiology and Medical Care Unit, St Bartholomew's and the Royal London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T W","family":"Meade","sequence":"additional","affiliation":[{"name":"aDepartment of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK, \n\nbMRC Epidemiology and Medical Care Unit, St Bartholomew's and the Royal London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2025091922532847000_85.4.385.1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/bmj.295.6593.297","article-title":"Phobic anxiety and ischaemic heart disease.","volume":"295","author":"Haines","year":"1987","journal-title":"BMJ"},{"key":"2025091922532847000_85.4.385.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.1992"},{"key":"2025091922532847000_85.4.385.3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0140-6736(84)91008-0","article-title":"Myocardial infarction and the emotional climate.","volume":"i","author":"Crisp","year":"1984","journal-title":"Lancet"},{"key":"2025091922532847000_85.4.385.4","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(84)92365-1","article-title":"Predicting myocardial infarction.","volume":"ii","author":"Thompson","year":"1984","journal-title":"Lancet"},{"key":"2025091922532847000_85.4.385.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(99)00091-4"},{"key":"2025091922532847000_85.4.385.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7196.1460"},{"key":"2025091922532847000_85.4.385.7","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(80)91498-1","article-title":"Haemostatic function and cardiovascular death: early results of a prospective study.","volume":"i","author":"Meade","year":"1980","journal-title":"Lancet"},{"key":"2025091922532847000_85.4.385.8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.bmb.a071448","article-title":"Population based distribution of haemostatic variables.","volume":"33","author":"Meade","year":"1977","journal-title":"Br Med Bull"},{"key":"2025091922532847000_85.4.385.9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.112.490.917"},{"key":"2025091922532847000_85.4.385.10","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(72)90088-8"},{"key":"2025091922532847000_85.4.385.11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/bmj.1.6000.7","article-title":"Jolly fat: the relation between obesity and psychoneurosis in the general population.","volume":"272","author":"Crisp","year":"1976","journal-title":"BMJ"},{"key":"2025091922532847000_85.4.385.12","unstructured":"World Health Organization Regional Office for Europe (1976) Myocardial infarction community registers. 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