{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:08:21Z","timestamp":1791223701501,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2000,11,8]]},"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To test the hypothesis that vitamin D receptor polymorphism is associated with calcific aortic valve stenosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN<\/jats:title>\n                  <jats:p>The distribution of one polymorphism of the vitamin D receptor (BsmI B\/b) was examined in 100 consecutive patients with calcific valvar aortic stenosis and compared with a control group of 100 patients (paired match for age, sex, and the presence of coronary artery disease from a total of 630 patients without calcified aortic valves). Polymerase chain reaction and restriction fragment length polymorphism were used to determine genotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There was a significant difference in vitamin D receptor allele and genotype frequencies between the two groups. The allele B had a higher prevalence in patients with calcific aortic stenosis (B\u2009=\u20090.56, b\u2009=\u20090.44) than in the control cohort (B\u2009=\u20090.40, b\u2009=\u20090.60) (p\u2009=\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>There is a significant association of vitamin D receptor polymorphism with calcific aortic valve stenosis. The B allele of the vitamin D receptor is more common in patients with calcific aortic valve stenosis. It now needs to be evaluated whether other genes that control calcium homeostasis are involved in the pathogenesis of this disorder.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.85.6.635","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"635-638","source":"Crossref","is-referenced-by-count":126,"title":["The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis"],"prefix":"10.1136","volume":"85","author":[{"given":"J R","family":"Ortlepp","sequence":"first","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ohme","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lauscher","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bleckmann","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Hanrath","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"2025100704103203000_85.6.635.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61880-1"},{"key":"2025100704103203000_85.6.635.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370107"},{"key":"2025100704103203000_85.6.635.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.844"},{"key":"2025100704103203000_85.6.635.4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease.","volume":"29","author":"Stewart","year":"1997","journal-title":"Am J Cardiol"},{"key":"2025100704103203000_85.6.635.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6665"},{"key":"2025100704103203000_85.6.635.6","doi-asserted-by":"publisher","DOI":"10.1038\/367284a0"},{"key":"2025100704103203000_85.6.635.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90404-2"},{"key":"2025100704103203000_85.6.635.8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2796.1997.tb00008.x","article-title":"Association of BsmI vitamin-D receptor gene polymorphism with combined bone mass in spine and proximal femur in Icelandic women.","volume":"241","author":"Sigurdsson","year":"1997","journal-title":"J Intern Med"},{"key":"2025100704103203000_85.6.635.9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.8.2077"},{"key":"2025100704103203000_85.6.635.10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90002-6"},{"key":"2025100704103203000_85.6.635.11","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.7.1049"},{"key":"2025100704103203000_85.6.635.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.12.3657"},{"key":"2025100704103203000_85.6.635.13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.6.2043"},{"key":"2025100704103203000_85.6.635.14","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.4.695"},{"key":"2025100704103203000_85.6.635.15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/8756-3282(95)00483-1","article-title":"Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population.","volume":"18","author":"Houston","year":"1996","journal-title":"Bone"},{"key":"2025100704103203000_85.6.635.16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jbmr.5650110614","article-title":"Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: the OFELY study.","volume":"11","author":"Garnero","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2025100704103203000_85.6.635.17","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.1.31"},{"key":"2025100704103203000_85.6.635.18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S8756-3282(97)00301-3","article-title":"Vitamin D receptor gene polymorphisms and peak bone mass in southern Chinese women.","volume":"22","author":"Kung","year":"1998","journal-title":"Bone"},{"key":"2025100704103203000_85.6.635.19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S8756-3282(98)00028-3","article-title":"Vitamin D receptor alleles do not predict bone mineral density or bone loss in Danish perimenopausal women.","volume":"22","author":"Hansen","year":"1998","journal-title":"Bone"},{"key":"2025100704103203000_85.6.635.20","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050116"},{"key":"2025100704103203000_85.6.635.21","doi-asserted-by":"publisher","DOI":"10.1038\/8702"},{"key":"2025100704103203000_85.6.635.22","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-45"},{"key":"2025100704103203000_85.6.635.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801083380202"},{"key":"2025100704103203000_85.6.635.24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.25.3218"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.85.6.635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:10:37Z","timestamp":1759835437000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.85.6.635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,6,1]]},"published-print":{"date-parts":[[2001,6,1]]}},"alternative-id":["10.1136\/heart.85.6.635"],"URL":"https:\/\/doi.org\/10.1136\/heart.85.6.635","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}