{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:20:26Z","timestamp":1791091226114,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To investigate whether CD40L\/CD154 on platelets and soluble CD40L\/CD154 may play a role in the inflammatory process of acute coronary syndromes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DESIGN AND SETTING<\/jats:title>\n                  <jats:p>Observational study in a university hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS<\/jats:title>\n                  <jats:p>15 patients with acute myocardial infarction, 25 patients with unstable angina, 15 patients with stable angina, and 12 controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                  <jats:p>CD40L\/CD154 on platelets, P-selectin\/CD62P on platelets, soluble CD40L\/CD154 serum concentrations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Mean (SD) CD40L\/CD154 expression on platelets was 6.2 (2.8) MFI (mean fluorescence intensity) in the infarct group, 11 (3.3) MFI in the unstable angina group (p\u2009&lt;\u20090.001 <jats:italic>v<\/jats:italic> infarction), 3.6 (0.9) MFI in the stable angina group (p\u2009&lt;\u20090.01 <jats:italic>v<\/jats:italic>infarction; p\u2009&lt;\u20090.001 <jats:italic>v<\/jats:italic> unstable angina), and 3.2 (1.0) MFI in the controls (p\u2009&lt;\u20090.01<jats:italic>v<\/jats:italic> infarction; p\u2009&lt;\u20090.001<jats:italic>v<\/jats:italic> unstable angina; NS<jats:italic>v<\/jats:italic> stable angina). Soluble CD40L\/CD154 concentration was 5.2 (1.1)\u2009ng\/ml in the infarct group, 4.2 (0.7)\u2009ng\/ml in the unstable angina group (p\u2009&lt;\u20090.001<jats:italic>v<\/jats:italic> infarction), 2.9 (1.0)\u2009ng\/ml in stable angina group (p\u2009&lt;\u20090.001 <jats:italic>v<\/jats:italic> infarction and unstable angina), and 3.0 (0.5)\u2009ng\/ml in the controls (p\u2009&lt;\u20090.001<jats:italic>v<\/jats:italic> infarction and unstable angina; NS<jats:italic>v<\/jats:italic> stable angina). At a six months follow up, there was lower expression of CD40L\/CD154 on platelets in patients with unstable angina (12.3 (3.6) <jats:italic>v<\/jats:italic> 3.8 (1.2) MFI, p\u2009&lt;\u20090.0001) and acute myocardial infarction (6.2 (2.8)<jats:italic>v<\/jats:italic> 3.5 (0.8) MFI, p\u2009&lt;\u20090.01) compared with their admission values six months earlier. Patients with unstable angina who needed redo coronary angioplasty (PTCA) or who had recurrence of angina were characterised by increased CD40L\/CD154 expression on platelets compared with the remainder of the study group (recurrence of angina: 12.7 (3.2) <jats:italic>v<\/jats:italic> 9.7 (1.6) MFI, p\u2009&lt;\u20090.05; re-do PTCA: 14.3 (4.2) <jats:italic>v<\/jats:italic>10.3 (2.1) MFI, p\u2009&lt;\u20090.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Both CD40L\/CD154 on platelets and soluble CD40L\/CD154 are raised in patients with unstable angina and myocardial infarction. These findings suggest that CD40\u2013CD40L\/CD154 interactions may play a pathogenic role in triggering and propagation of acute coronary syndromes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heart.86.6.649","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:19Z","timestamp":1027751539000},"page":"649-655","source":"Crossref","is-referenced-by-count":132,"title":["Patients with acute coronary syndromes express enhanced CD40 ligand\/CD154 on platelets"],"prefix":"10.1136","volume":"86","author":[{"given":"C 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