{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:04:25Z","timestamp":1774566265966,"version":"3.50.1"},"reference-count":27,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Objective: To investigate the effect of beraprost sodium, an orally active prostacyclin analogue, on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension and chronic thromboembolic pulmonary hypertension.<\/jats:p>\n               <jats:p>Patients and design: Symptom limited cardiopulmonary exercise testing was performed before and 3 (1) months (mean (SEM)) after beraprost treatment in 30 patients with precapillary pulmonary hypertension (14 with primary pulmonary hypertension and 16 with chronic thromboembolic pulmonary hypertension).<\/jats:p>\n               <jats:p>Results: Long term treatment with beraprost resulted in significant increases (mean (SEM)) in peak workload (87 (4) W to 97 (5) W, p &lt; 0.001) and peak oxygen consumption (peak V\u0307<jats:sc>o<\/jats:sc>\n                  <jats:sub>2<\/jats:sub>, 14.9 (0.7) ml\/kg\/min to 16.8 (0.7) ml\/kg\/min, p &lt; 0.001). Beraprost decreased the ventilatory response to carbon dioxide production during exercise (V\u0307<jats:sc>e<\/jats:sc>\u2013V\u0307<jats:sc>co<\/jats:sc>\n                  <jats:sub>2<\/jats:sub> slope, 42 (2) to 37 (1), p &lt; 0.001). No significant difference in the responses of these variables to beraprost treatment was observed between patients with primary pulmonary hypertension and chronic thromboembolic pulmonary hypertension.<\/jats:p>\n               <jats:p>Conclusions: Oral administration of beraprost sodium may improve exercise capacity and ventilatory efficiency in patients with both primary and chronic thromboembolic pulmonary hypertension.<\/jats:p>","DOI":"10.1136\/heart.87.4.340","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:30:44Z","timestamp":1027751444000},"page":"340-345","source":"Crossref","is-referenced-by-count":52,"title":["Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension"],"prefix":"10.1136","volume":"87","author":[{"given":"N","family":"Nagaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Oya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Uematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kyotani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Miyatake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2025092100224436000_87.4.340.1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","volume":"107","year":"1987","journal-title":"Ann 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