{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:28:22Z","timestamp":1790198902479,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2002,11]]},"abstract":"\n Objective:<\/jats:bold> To examine the relation between plasma concentrations of interleukin-18 (IL-18), the interferon \u03b3 inducing factor, and clinical instability of coronary artery disease.<\/jats:p>\n \n Design and setting:<\/jats:bold> Observational study in a university hospital.<\/jats:p>\n \n Patients:<\/jats:bold> 11 patients with unstable angina and negative troponin I, 21 patients with acute non-Q wave myocardial infarction (MI), 21 patients with acute Q wave MI, 9 patients with stable angina, and 11 controls.<\/jats:p>\n \n Main outcome measures:<\/jats:bold> Plasma IL-18 concentrations and their relation to clinical instability and myocardial dysfunction.<\/jats:p>\n \n Results:<\/jats:bold> Plasma concentrations of IL-18 were significantly increased in the unstable angina and MI groups in comparison with the stable angina and control groups (p < 0.01). No difference in IL-18 concentrations were found between patients with unstable angina, patients with non-Q wave MI, and patients with Q wave MI. Plasma IL-18 concentrations significantly correlated with decreased left ventricular ejection fraction (p = 0.01).<\/jats:p>\n \n Conclusions:<\/jats:bold> Plasma IL-18 concentrations are increased in patients with acute coronary syndromes and correlate with the severity of myocardial dysfunction.<\/jats:p>","DOI":"10.1136\/heart.88.5.467","type":"journal-article","created":{"date-parts":[[2002,10,15]],"date-time":"2002-10-15T14:02:42Z","timestamp":1034690562000},"page":"467-469","source":"Crossref","is-referenced-by-count":119,"title":["Increased plasma concentrations of interleukin-18 in acute coronary syndromes"],"prefix":"10.1136","volume":"88","author":[{"given":"Z","family":"Mallat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Fressonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Alouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Scoazec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Beaufils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chvatchko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tedgui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2025101714564302000_88.5.467.1","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"2025101714564302000_88.5.467.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60389-2"},{"key":"2025101714564302000_88.5.467.3","first-page":"483","volume":"11","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"2025101714564302000_88.5.467.4","doi-asserted-by":"publisher","DOI":"10.1161\/hc3901.096721"},{"key":"2025101714564302000_88.5.467.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041611398"},{"key":"2025101714564302000_88.5.467.6","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.668"},{"key":"2025101714564302000_88.5.467.7","first-page":"E41","volume":"89","year":"2001","journal-title":"Circ Res"},{"key":"2025101714564302000_88.5.467.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.734"},{"key":"2025101714564302000_88.5.467.9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1379"},{"key":"2025101714564302000_88.5.467.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.4.778"},{"key":"2025101714564302000_88.5.467.11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119114"},{"key":"2025101714564302000_88.5.467.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.6.836"},{"key":"2025101714564302000_88.5.467.13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4049\/jimmunol.163.2.583","volume":"163","year":"1999","journal-title":"J Immunol"},{"key":"2025101714564302000_88.5.467.14","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80111-9"},{"key":"2025101714564302000_88.5.467.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.915"},{"key":"2025101714564302000_88.5.467.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.4.438"},{"key":"2025101714564302000_88.5.467.17","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1096\/fasebj.13.15.2195","volume":"13","year":"1999","journal-title":"FASEB J"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.88.5.467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:56:49Z","timestamp":1760738209000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.88.5.467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2002,11,1]]},"published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1136\/heart.88.5.467"],"URL":"https:\/\/doi.org\/10.1136\/heart.88.5.467","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}