{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:16Z","timestamp":1787017096764,"version":"build-2736575974"},"reference-count":16,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2003,3]]},"abstract":"\n Background:<\/jats:bold>\n Clinical guidelines currently suggest that transthoracic echocardiography (TTE) be carried out in all patients with suspected endocarditis, but the use of TTE where there is a low probability of infective endocarditis has a poor diagnostic yield. This screening approach may no longer be appropriate.\n <\/jats:p>\n \n Objective:<\/jats:bold>\n To examine whether clinical criteria might aid decision making with respect to the use of TTE in possible endocarditis.\n <\/jats:p>\n \n Design:<\/jats:bold>\n A retrospective review of patient records.\n <\/jats:p>\n \n Setting:<\/jats:bold>\n Cardiology department of a tertiary referral centre.\n <\/jats:p>\n \n Patients:<\/jats:bold>\n 500 consecutive hospital inpatients referred for TTE to exclude endocarditis.\n <\/jats:p>\n \n Main outcome measures:<\/jats:bold>\n Evidence of endocardial vegetations on TTE and the presence of predetermined clinical criteria that may predispose to, or be suggestive of, endocarditis.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Evidence of infective endocarditis was detected on echocardiography in 43 of the 500 patients (8.6%). In 239 patients (48%), vegetations and certain prespecified clinical criteria were both absent. These criteria were: vasculitic\/embolic phenomena; the presence of central venous access; a recent history of injected drug use; presence of a prosthetic valve; and positive blood cultures. The collective absence of these five criteria indicated a zero probability of TTE showing evidence of endocarditis.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n The use of simple clinical criteria during the decision making process may avoid many unnecessary TTE examinations in hospital inpatients with a low probability of endocarditis.\n <\/jats:p>","DOI":"10.1136\/heart.89.3.273","type":"journal-article","created":{"date-parts":[[2003,2,18]],"date-time":"2003-02-18T15:43:45Z","timestamp":1045583025000},"page":"273-275","source":"Crossref","is-referenced-by-count":68,"title":["Clinical criteria and the appropriate use of transthoracic echocardiography for the exclusion of infective endocarditis"],"prefix":"10.1136","volume":"89","author":[{"given":"K","family":"Greaves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Celermajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2025101712165448000_89.3.273.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.4.730"},{"key":"2025101712165448000_89.3.273.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.25.2936"},{"key":"2025101712165448000_89.3.273.3","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.153.9.950"},{"key":"2025101712165448000_89.3.273.4","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90104-6"},{"key":"2025101712165448000_89.3.273.5","first-page":"43","volume":"9","year":"1988","journal-title":"Eur Heart J"},{"key":"2025101712165448000_89.3.273.6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/eurheartj\/8.suppl_J.287","volume":"8","year":"1987","journal-title":"Eur Heart J"},{"key":"2025101712165448000_89.3.273.7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90004-1"},{"key":"2025101712165448000_89.3.273.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90072-9"},{"key":"2025101712165448000_89.3.273.9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.CIR.61.2.374","volume":"61","year":"1980","journal-title":"Circulation"},{"key":"2025101712165448000_89.3.273.10","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0735-1097(10)80005-1","volume":"15","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"2025101712165448000_89.3.273.11","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.53.3.310"},{"key":"2025101712165448000_89.3.273.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90143-0"},{"key":"2025101712165448000_89.3.273.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00216-8"},{"key":"2025101712165448000_89.3.273.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00232-6"},{"key":"2025101712165448000_89.3.273.15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7326\/0003-4819-94-4-505","volume":"94","year":"1981","journal-title":"Ann Intern Med"},{"key":"2025101712165448000_89.3.273.16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90519-2"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.89.3.273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:17:06Z","timestamp":1760728626000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.89.3.273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,3,1]]},"published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1136\/heart.89.3.273"],"URL":"https:\/\/doi.org\/10.1136\/heart.89.3.273","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}