{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:31:24Z","timestamp":1791977484742,"version":"4.4.0"},"reference-count":27,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2003,2,19]]},"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    To develop and test a new concept of the degradation kinetics of newly developed coronary stents consisting of magnesium alloys.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Design of a coronary stent prototype consisting of the non-commercial magnesium based alloy AE21 (containing 2% aluminium and 1% rare earths) with an expected 50% loss of mass within six months. Eleven domestic pigs underwent coronary implantation of 20 stents (overstretch injury).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    No stent caused major problems during implantation or showed signs of initial breakage in the histological evaluation. There were no thromboembolic events. Quantitative angiography at follow up showed a significant (p &lt; 0.01) 40% loss of perfused lumen diameter between days 10 and 35, corresponding to neointima formation seen on histological analysis, and a 25% re-enlargement (p &lt; 0.05) between days 35 and 56 caused by vascular remodelling (based on intravascular ultrasound) resulting from the loss of mechanical integrity of the stent. Inflammation (p &lt; 0.001) and neointimal plaque area (p &lt; 0.05) depended significantly on injury score. Planimetric degradation correlated with time (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.67, p &lt; 0.01).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Vascular implants consisting of magnesium alloy degradable by biocorrosion seem to be a realistic alternative to permanent implants.\n                  <\/jats:p>","DOI":"10.1136\/heart.89.6.651","type":"journal-article","created":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T16:29:21Z","timestamp":1052929761000},"page":"651-656","source":"Crossref","is-referenced-by-count":711,"title":["Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?"],"prefix":"10.1136","volume":"89","author":[{"given":"B","family":"Heublein","sequence":"first","affiliation":[{"name":"Hannover Medical School, Leibniz Laboratory for Biotechnology and Artificial Organs, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rohde","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Leibniz Laboratory for Biotechnology and Artificial Organs, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kaese","sequence":"additional","affiliation":[{"name":"Institute of Materials Sciences, University of Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Institute of Materials Sciences, University of Hannover, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Haverich","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Leibniz Laboratory for Biotechnology and Artificial Organs, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2025091923242614000_89.6.651.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.371"},{"key":"2025091923242614000_89.6.651.2","doi-asserted-by":"publisher","DOI":"10.1007\/s001040050734"},{"key":"2025091923242614000_89.6.651.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.7.1690"},{"key":"2025091923242614000_89.6.651.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.3.395"},{"key":"2025091923242614000_89.6.651.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.44"},{"key":"2025091923242614000_89.6.651.6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90476-4"},{"key":"2025091923242614000_89.6.651.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00584-0"},{"key":"2025091923242614000_89.6.651.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.399"},{"key":"2025091923242614000_89.6.651.9","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(96)86738-X"},{"key":"2025091923242614000_89.6.651.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.1.28"},{"key":"2025091923242614000_89.6.651.11","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1997.0753"},{"key":"2025091923242614000_89.6.651.12","unstructured":"Sawyer PN, Brattain WH, Boddy PJ. 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