{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:49:21Z","timestamp":1787500161471,"version":"build-2736575974"},"reference-count":13,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2003,8]]},"abstract":"\n Objective:<\/jats:bold>\n To close perimembranous ventricular septal defects (PMVSDs) in children with the new Amplatzer asymmetric ventricular septal defect occluder (AAVSDO).\n <\/jats:p>\n \n Patients and design:<\/jats:bold>\n 10 children, aged 1.5\u201312 years, with PMVSDs underwent transcatheter closure with the AAVSDO. The device consists of two low profile disks made of Nitinol wire mesh with a 1.5 mm connecting waist. The left disk is 5 mm towards the apex and only 0.5 mm towards the aortic valve. The right disk is 4 mm larger than the waist. The prosthesis diameter was chosen to be 1\u20132 mm larger than the largest diameter of the defect (determined by transoesophageal echocardiography and angled angiocardiography). A 7\u20138 French gauge sheath was used to deliver the AAVSDO.\n <\/jats:p>\n \n Results:<\/jats:bold>\n The PMVSD diameter ranged from 2\u20138 mm. The device diameter ranged from 4\u20138 mm. After deployment of the prosthesis there was no residual shunt in 9 of 10 patients (90%). In one patient there was a trivial residual shunt that disappeared at the three month follow up. Three patients developed transient complete left bundle branch block. No other complications were observed.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n The AAVSDO appears to be a promising device for transcatheter closure of PMVSDs in children. Further studies are required to document its efficacy, safety, and long term results in a larger patient population.\n <\/jats:p>","DOI":"10.1136\/heart.89.8.918","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T15:35:30Z","timestamp":1058196930000},"page":"918-922","source":"Crossref","is-referenced-by-count":82,"title":["Transcatheter closure of perimembranous ventricular septal defects with the Amplatzer asymmetric ventricular septal defect occluder: preliminary experience in children"],"prefix":"10.1136","volume":"89","author":[{"given":"B D","family":"Thanopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Tsaousis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Karanasios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N G","family":"Eleftherakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Paphitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,7,14]]},"reference":[{"key":"2025092100460856000_89.8.918.1","unstructured":"Mavroudis C, Baker CL, Idriss FS. Ventricular septal defect. In: Mavroudis C, Baker CL, eds. Pediatric cardiac surgery, 2nd ed. St Louis: Mosby, 1994:201\u201324."},{"key":"2025092100460856000_89.8.918.2","first-page":"361","volume":"78","year":"1998","journal-title":"Circulation"},{"key":"2025092100460856000_89.8.918.3","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1056\/NEJM199105093241903","volume":"324","year":"1991","journal-title":"N Engl J Med"},{"key":"2025092100460856000_89.8.918.4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.368"},{"key":"2025092100460856000_89.8.918.5","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900093"},{"key":"2025092100460856000_89.8.918.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70122-5"},{"key":"2025092100460856000_89.8.918.7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.3.276"},{"key":"2025092100460856000_89.8.918.8","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726X(200008)50:4<502::AID-CCD29>3.0.CO;2-8"},{"key":"2025092100460856000_89.8.918.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00011-X"},{"key":"2025092100460856000_89.8.918.10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0735-1097(97)84186-1","volume":"31","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"2025092100460856000_89.8.918.11","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10292"},{"key":"2025092100460856000_89.8.918.12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.CIR.87.1.38","volume":"87","year":"1993","journal-title":"Circulation"},{"key":"2025092100460856000_89.8.918.13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(200002)49:2<167::AID-CCD11>3.0.CO;2-S"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heart.89.8.918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T07:46:15Z","timestamp":1758440775000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heart.89.8.918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,14]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2003,7,14]]},"published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1136\/heart.89.8.918"],"URL":"https:\/\/doi.org\/10.1136\/heart.89.8.918","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,14]]}}}