{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:07:00Z","timestamp":1785002820441,"version":"3.55.0"},"reference-count":26,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2011,9,21]]},"published-print":{"date-parts":[[2012,2,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effects of atorvastatin on endothelial function and low-grade systemic inflammation in subjects with successful surgery for aortic coarctation repair (SCR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Open-label study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Outpatients visiting the adult congenital heart disease department of our hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>34 young people with SCR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Patients with SCR received atorvastatin 10\u2005mg\/day (n=17) or no treatment (n=17) for 4\u2005weeks. At baseline and at 4\u2005weeks, endothelial function was assessed by flow-mediated dilatation (FMD) of the right brachial artery, and blood samples were obtained. Serum levels of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined by ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Effects of treatment on FMD and serum levels of IL-1b, IL-6 and sVCAM-1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>FMD in the atorvastatin group was significantly improved after 4\u2005weeks (from 6.46\u00b10.95% to 11.24\u00b11.38%, p&lt;0.01), while remaining unchanged in the control group (from 6.74\u00b10.58% to 6.95\u00b10.53%, p=NS). Even though atorvastatin had no effect on serum IL-6 levels (0.62 (0.37\u20130.88)\u2005pg\/ml to 0.53 (0.28\u20130.73)\u2005pg\/ml, p=NS), it significantly reduced circulating levels of IL-1b (from 1.17 (0.92\u20131.77)\u2005pg\/ml to 1.02 (0.75\u20131.55)\u2005pg\/ml, p&lt;0.05) and sVCAM-1 (from 883.4 (660.3\u20131093.1)\u2005ng\/ml to 801.4 (566.7\u20131030.2)\u2005ng\/ml, p&lt;0.05). No changes were seen in serum levels of IL-6, IL-1b and sVCAM-1 in the control group after 4\u2005weeks compared with baseline (p=NS for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Atorvastatin treatment for 4\u2005weeks in subjects with SCR significantly improved endothelial function and suppressed systemic inflammatory status by decreasing circulating levels of IL-1b and sVCAM-1.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2011-300287","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T21:42:24Z","timestamp":1320961344000},"page":"325-329","source":"Crossref","is-referenced-by-count":34,"title":["Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of 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