{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:27:05Z","timestamp":1790116025653,"version":"4.0.1"},"reference-count":20,"publisher":"BMJ","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2012,5,1]]},"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The role of high sensitivity troponin T (hs-TnT) in the convalescence phase after an acute coronary syndrome (ACS) is unknown. The authors aim to assess the prognostic utility of a single hs-TnT level at 7-week post-ACS. Second, the authors evaluated whether any serial changes in hs-TnT between the index admission and 7\u2005weeks post-ACS had any link with the prognosis. Third, the authors assessed whether the prognostic utility of hs-TnT is independent of various echocardiographic abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The authors measured hs-TnT levels in 326 consecutive patients at 7\u2005weeks after an ACS event. The composite end point of death from any cause or acute myocardial infarction was evaluated over a median duration of 30\u2005months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A high 7-week hs-TnT (&gt;14\u2005ng\/l) predicted adverse clinical outcomes independent of conventional risk factors, left ventricular dysfunction and left ventricular hypertrophy on echocardiography (adjusted RR: 2.69 (95% CI 1.45 to 5.00)). Patients with persistent hs-TnT elevation at 7\u2005weeks were also at an increased risk of cardiovascular events compared with those with an initial high hs-TnT which then normalised (unadjusted RR 3.39 (95% CI 2.02 to 5.68)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The authors have demonstrated the prognostic utility of a single 7-week hs-TnT measurement in routine ACS patients and that it could be used to assist medium term risk stratification in this patient cohort. In addition, the authors also showed that hs-TnT predicted long-term adverse prognosis independent of various echo parameters. Future studies should evaluate whether tailoring specific treatment interventions to higher risk individuals as identified by an elevated hs-TnT during the convalescence phase of ACS would improve clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-301635","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:50:42Z","timestamp":1339462242000},"page":"1160-1165","source":"Crossref","is-referenced-by-count":17,"title":["The prognostic value of high sensitivity troponin T 7 weeks after an acute coronary syndrome"],"prefix":"10.1136","volume":"98","author":[{"given":"Donald S C","family":"Ang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle P C","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellie","family":"Dow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chim","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Struthers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"2025092005055225000_98.15.1160.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"2025092005055225000_98.15.1160.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.05.023"},{"key":"2025092005055225000_98.15.1160.3","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.134460"},{"key":"2025092005055225000_98.15.1160.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805299"},{"key":"2025092005055225000_98.15.1160.5","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi187"},{"key":"2025092005055225000_98.15.1160.6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160234"},{"key":"2025092005055225000_98.15.1160.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011053"},{"key":"2025092005055225000_98.15.1160.8","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.132654"},{"key":"2025092005055225000_98.15.1160.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900428"},{"key":"2025092005055225000_98.15.1160.10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"2025092005055225000_98.15.1160.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"2025092005055225000_98.15.1160.12","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen003"},{"key":"2025092005055225000_98.15.1160.13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"2025092005055225000_98.15.1160.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.09.018"},{"key":"2025092005055225000_98.15.1160.15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1708"},{"key":"2025092005055225000_98.15.1160.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041661.63285.AE"},{"key":"2025092005055225000_98.15.1160.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13976-1"},{"key":"2025092005055225000_98.15.1160.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.04.024"},{"key":"2025092005055225000_98.15.1160.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.02.346"},{"key":"2025092005055225000_98.15.1160.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109483.45211.8F"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2012-301635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:05:57Z","timestamp":1758369957000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2012-301635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,11]]},"references-count":20,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2012,7,5]]},"published-print":{"date-parts":[[2012,8,1]]}},"alternative-id":["10.1136\/heartjnl-2012-301635"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2012-301635","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,11]]}}}