{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:47:35Z","timestamp":1789642055702,"version":"4.0.0"},"reference-count":29,"publisher":"BMJ","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2012,5,15]]},"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-procedural aortic regurgitation (AR) has been described in a large number of patients receiving transcatheter aortic valve implantation (TAVI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to examine the intraoperative 2-dimensional (2D) and 3-dimensional (3D) echocardiographic features of the aortic valve associated with significant post-procedural paravalvular AR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 135 patients (81\u00b17\u2005years) with severe symptomatic aortic stenosis, who underwent TAVI, were imaged with comprehensive 2D and 3D transoesophageal echocardiography before the procedure and peri-procedure. Various baseline and peri-procedural echocardiographic characteristics were tested to predict paravalvular AR post-TAVI: calcifications at the aortic valve commissures and leaflets, \u2018aortic annulus eccentricity index\u2019, \u2018area cover index\u2019, overlap between aortic prosthesis and anterior mitral leaflet. Post-procedural paravalvular AR\u22652 was considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Successful TAVI was achieved in all patients. The incidence of paravalvular AR\u22652 immediately after the procedure was 21% (28 patients). Commissural calcifications and, particularly, the calcification of the commissure between the right coronary and non-coronary cusps was significantly more frequent in presence of paravalvular AR; the area cover index pre-TAVI was significantly lower among patients with AR (11.1\u00b111.8% vs 20.8\u00b112.5%, p=0.0004). Multivariate analysis revealed that calcification of the commissure between the right coronary and non-coronary cusps (OR=2.66, 95% CI 1.39 to 5.12, p=0.001), and the area cover index pre-TAVI (OR=0.95, 95% CI 0.91 to 0.99, p=0.006) were the only independent predictors of significant paravalvular AR after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative 2D and 3D transoesophageal echocardiography identified calcification of the commissure between the right coronary and non-coronary cusps and the area cover index as independent predictors of significant paravalvular AR following TAVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-301998","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T02:43:06Z","timestamp":1343011386000},"page":"1229-1236","source":"Crossref","is-referenced-by-count":93,"title":["Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation"],"prefix":"10.1136","volume":"98","author":[{"given":"Paola","family":"Gripari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Hooi","family":"Ewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold C T","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cefal\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Schalij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Ajmone","family":"Marsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Tamborini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pepi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,7,22]]},"reference":[{"key":"2025101722374291000_98.16.1229.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.639450"},{"key":"2025101722374291000_98.16.1229.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"2025101722374291000_98.16.1229.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"2025101722374291000_98.16.1229.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.930453"},{"key":"2025101722374291000_98.16.1229.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.014"},{"key":"2025101722374291000_98.16.1229.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"2025101722374291000_98.16.1229.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698258"},{"key":"2025101722374291000_98.16.1229.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.032"},{"key":"2025101722374291000_98.16.1229.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn183"},{"key":"2025101722374291000_98.16.1229.10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"2025101722374291000_98.16.1229.11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq018"},{"key":"2025101722374291000_98.16.1229.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"2025101722374291000_98.16.1229.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.021"},{"key":"2025101722374291000_98.16.1229.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"2025101722374291000_98.16.1229.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.001"},{"key":"2025101722374291000_98.16.1229.16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.132092"},{"key":"2025101722374291000_98.16.1229.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"2025101722374291000_98.16.1229.18","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1316"},{"key":"2025101722374291000_98.16.1229.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01361-4"},{"key":"2025101722374291000_98.16.1229.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70124-9"},{"key":"2025101722374291000_98.16.1229.21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.837807"},{"key":"2025101722374291000_98.16.1229.22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp537"},{"key":"2025101722374291000_98.16.1229.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.11.015"},{"key":"2025101722374291000_98.16.1229.24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2010.03.004","article-title":"Association of aortic valve calcification severity with the degree of aortic regurgitation after transcatheter aortic valve implantation","volume":"150","author":"Koos","year":"2010","journal-title":"Int J Cardiol"},{"key":"2025101722374291000_98.16.1229.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.01.014"},{"key":"2025101722374291000_98.16.1229.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.023"},{"key":"2025101722374291000_98.16.1229.27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.885152"},{"key":"2025101722374291000_98.16.1229.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.07.003"},{"key":"2025101722374291000_98.16.1229.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.075"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2012-301998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T05:37:49Z","timestamp":1760765869000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2012-301998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,22]]},"references-count":29,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2012,7,22]]},"published-print":{"date-parts":[[2012,8,15]]}},"alternative-id":["10.1136\/heartjnl-2012-301998"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2012-301998","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717954109.793509658","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717954109.793459814","asserted-by":"object"}]},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,22]]}}}