{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:17:15Z","timestamp":1777544235059,"version":"3.51.4"},"reference-count":29,"publisher":"BMJ","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2012,6,19]]},"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the differential implications of cardiac biomarker type on peri-procedural myocardial infarction (PMI) reporting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The Resolute \u2018All-Comers\u2019 stent trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Blood samples for creatine kinase (CK), CK-myoband (CK-MB) mass or cardiac troponin (cTn) (optional) were collected before and at 6, 12 and 18\u2005h after the assigned percutaneous coronary intervention or at discharge. PMIs were adjudicated using either the 2007 universal definition of MI (type-4a) or the extended historical definition of MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>2121\/2292 patients (92.5%) had an analysable dataset for either biomarker. 890\/2121 patients (42%) presented with an acute coronary syndrome (ACS). 267\/890 patients (30%) were within 24\u2005h of an ST-segment elevation MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Type-4a MI was diagnosed in 208\/2121 patients (9.8%) when cTn was used (CK-MB mass if cTn not available), and in 93\/2121 of patients (4.4%) when CK-MB mass was used (cTn if CK-MB mass not available). With the extended historical CK-based definition of MI, PMI was diagnosed in 65\/2121 patients (3.1%). Adjudication of type-4a MI in patients with an ACS was problematic with &lt;10% of the potential type-4a MI being confirmed as an event, as compared with approximately 95% in stable patients undergoing elective PCI. Type-4a MI was not associated with the subsequent hazard for cardiac mortality (p=0.6).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The percentage of adjudicated PMI events is driven by the MI-definition criteria and biomarker type. Type-4a MI may not be a reliable component of the primary composite end point in coronary stent investigations which recruit patients with ACS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ClinicalTrials.gov\">http:\/\/www.ClinicalTrials.gov<\/jats:ext-link>; Unique identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT00617084\">NCT00617084<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-302267","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T20:54:54Z","timestamp":1342904094000},"page":"1424-1430","source":"Crossref","is-referenced-by-count":26,"title":["Different cardiac biomarkers to detect peri-procedural myocardial infarction in contemporary coronary stent trials: impact on outcome reporting"],"prefix":"10.1136","volume":"98","clinical-trial-number":[{"clinical-trial-number":"nct00617084","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00617084","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Pascal","family":"Vranckx","sequence":"first","affiliation":[{"name":"1Department of Cardiac Intensive Care and Interventional Cardiology, Hartcentrum Hasselt, Hasselt, Belgium"},{"name":"2Cardialysis, Clinical Research Management and Core Laboratories, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasim","family":"Farooq","sequence":"additional","affiliation":[{"name":"3Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scot","family":"Garg","sequence":"additional","affiliation":[{"name":"3Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit-Anne","family":"Van Es","sequence":"additional","affiliation":[{"name":"2Cardialysis, Clinical Research Management and Core Laboratories, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigmund","family":"Silber","sequence":"additional","affiliation":[{"name":"4Department of Cardiology, Kardiologische Praxis und Praxisklinik, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"5Department of Interventional Cardiology, Bern University Hospital, Bern, 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