{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:03Z","timestamp":1791919983391,"version":"4.3.4"},"reference-count":30,"publisher":"BMJ","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2012,7,12]]},"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to investigate the role of intraplaque neovascularisation (NV) in culprit lesions and non-culprit lesions of unstable angina pectoris (UAP) and in lesions of stable angina pectoris (SAP) using optical coherence tomography (OCT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This study was a retrospective study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The significance of NV for culprit and non-culprit plaques remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A total of 356 plaques from 92 UAP patients and 25 SAP patients who underwent OCT imaging were divided into three groups: culprit lesions in UAP (92), non-culprit lesions in UAP (203) and lesions of SAP (61).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>NV and plaque characteristics were examined by OCT and plaques with and without NV were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among UAP culprit lesions, plaques with NV had significantly higher incidence of thin cap fibroatheroma (81% vs 47%, p=0.002) compared with those without NV. In addition, the fibrous cap was thinner (56\u00b120\u2005\u03bcm vs 75\u00b130\u2005\u03bcm, p&lt;0.001), lipid arc was greater (254\u00b166\u00b0 vs 222\u00b165\u00b0, p=0.024) and lipid core length was longer (13\u00b15\u2005mm vs 10\u00b16\u2005mm, p=0.007). No significant difference was observed between non-culprit lesions of UAP with and without NV, and between lesions of SAP with and without NV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with UAP, the culprit plaques with NV had vulnerable features such as thinner fibrous cap, greater lipid arc, longer lipid core length and more frequent thin cap fibroatheroma compared with those without NV. In both non-culprit lesions of UAP patients and in lesions of SAP patients NV was not associated with vulnerable plaque characteristics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-302445","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T20:35:41Z","timestamp":1344285341000},"page":"1504-1509","source":"Crossref","is-referenced-by-count":61,"title":["Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study"],"prefix":"10.1136","volume":"98","author":[{"given":"Jinwei","family":"Tian","sequence":"first","affiliation":[{"name":"1Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Hou","sequence":"additional","affiliation":[{"name":"1Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[{"name":"1Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"2Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"2Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 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