{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:13:56Z","timestamp":1788758036885,"version":"build-2803163510"},"reference-count":140,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"published-print":{"date-parts":[[2013,6,1]]},"DOI":"10.1136\/heartjnl-2012-302535","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T04:52:32Z","timestamp":1359003152000},"page":"759-766","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":371,"title":["The role of uric acid in the pathogenesis of human cardiovascular disease"],"prefix":"10.1136","volume":"99","author":[{"given":"Mehmet","family":"Kanbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Afsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Hee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Rodriguez-Iturbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"key-10.1136\/heartjnl-2012-302535-1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF00163854","article-title":"Two independent mutational events in the loss of urate oxidase during hominoid evolution","volume":"34","author":"Wu","year":"1992","journal-title":"J Mol Evol"},{"key":"key-10.1136\/heartjnl-2012-302535-2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/oxfordjournals.molbev.a004123","article-title":"Loss of urate oxidase activity in hominoids and its evolutionary implications","volume":"19","author":"Oda","year":"2002","journal-title":"Mol Biol Evol"},{"key":"key-10.1136\/heartjnl-2012-302535-3","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.1136\/heartjnl-2012-302535-4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000028589.66335.AA","article-title":"Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity","volume":"40","author":"Watanabe","year":"2002","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/evan.20266","article-title":"Fructose, Uricase, and the Back-to-Africa Hypothesis","volume":"19","author":"Johnson","year":"2010","journal-title":"Evol Anthropol"},{"key":"key-10.1136\/heartjnl-2012-302535-6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00360-008-0291-7","article-title":"Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?","volume":"179","author":"Johnson","year":"2009","journal-title":"J Comp Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semnephrol.2004.09.002","article-title":"Uric acid, evolution and primitive cultures","volume":"25","author":"Johnson","year":"2005","journal-title":"Semin Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-8","first-page":"899","article-title":"Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease","volume":"86","author":"Johnson","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"key-10.1136\/heartjnl-2012-302535-9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr Rev"},{"key":"key-10.1136\/heartjnl-2012-302535-10","doi-asserted-by":"crossref","DOI":"10.1002\/9781119198048","volume-title":"The fat switch","author":"Johnson","year":"2012"},{"key":"key-10.1136\/heartjnl-2012-302535-11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/oxfordjournals.aje.a115593","article-title":"Precursors of essential hypertension: pulmonary function, heart rate, uric acid, serum cholesterol, and other serum chemistries","volume":"131","author":"Selby","year":"1990","journal-title":"Am J Epidemiol"},{"key":"key-10.1136\/heartjnl-2012-302535-12","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/01.HYP.17.6.969","article-title":"Predictors of an increased risk of future hypertension in Utah. A screening analysis","volume":"17","author":"Hunt","year":"1991","journal-title":". Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-13","first-page":"677","article-title":"Serum uric acid and hypertension: the Olivetti heart study","volume":"8","author":"Jossa","year":"1994","journal-title":"J Hum Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.jhh.1000740","article-title":"Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study. Coronary Artery Risk Development in (Young) Adults","volume":"13","author":"Dyer","year":"1999","journal-title":"J Hum Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1097\/00004872-200107000-00005","article-title":"Serum uric acid and the risk for hypertension and Type 2 diabetes in Japanese men: The Osaka Health Survey","volume":"19","author":"Taniguchi","year":"2001","journal-title":"J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1291\/hypres.24.531","article-title":"Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study","volume":"24","author":"Imazu","year":"2001","journal-title":"Hypertens Res"},{"key":"key-10.1136\/heartjnl-2012-302535-17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1291\/hypres.27.227","article-title":"Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan","volume":"27","author":"Nagahama","year":"2004","journal-title":"Hypertens Res"},{"key":"key-10.1136\/heartjnl-2012-302535-18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.HYP.0000150784.92944.9a","article-title":"Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence","volume":"45","author":"Sundstrom","year":"2005","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/sj.jhh.1002095","article-title":"The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study","volume":"20","author":"Shankar","year":"2006","journal-title":"J Hum Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/01.HYP.0000248752.08807.4c","article-title":"Uric acid and the development of hypertension: the normative aging study","volume":"48","author":"Perlstein","year":"2006","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-21","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/01.HYP.0000249768.26560.66","article-title":"Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study","volume":"48","author":"Mellen","year":"2006","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.0000254480.64564.b6","article-title":"Hyperuricemia and incidence of hypertension among men without metabolic syndrome","volume":"49","author":"Krishnan","year":"2007","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-23","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1373\/clinchem.2009.124891","article-title":"Plasma uric acid and hypertension in a Chinese community: prospective study and metaanalysis","volume":"55","author":"Zhang","year":"2009","journal-title":"Clin Chem"},{"key":"key-10.1136\/heartjnl-2012-302535-24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archinternmed.2008.521","article-title":"Uric acid and insulin sensitivity and risk of incident hypertension","volume":"169","author":"Forman","year":"2009","journal-title":"Arch Intern Med"},{"key":"key-10.1136\/heartjnl-2012-302535-25","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.metabol.2012.05.006","article-title":"Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: a Chinese cohort study","volume":"61","author":"Yang","year":"2012","journal-title":"Metabolism"},{"key":"key-10.1136\/heartjnl-2012-302535-26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/acr.20344","article-title":"Hyperuricemia and incident hypertension: A systematic review and meta-analysis","volume":"63","author":"Grayson","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"key-10.1136\/heartjnl-2012-302535-27","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/hy1101.092839","article-title":"Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism","volume":"38","author":"Mazzali","year":"2001","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-28","first-page":"F991","article-title":"Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism","volume":"282","author":"Mazzali","year":"2002","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1523-1755.2005.00074.x","article-title":"Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats","volume":"67","author":"Sanchez-Lozada","year":"2005","journal-title":"Kidney Int"},{"key":"key-10.1136\/heartjnl-2012-302535-30","first-page":"F1134","article-title":"Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia","volume":"295","author":"Sanchez-Lozada","year":"2008","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-31","first-page":"F1238","article-title":"Effects of acute and chronic L-arginine treatment in experimental hyperuricemia","volume":"292","author":"Sanchez-Lozada","year":"2007","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-32","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMra011078","article-title":"Subtle acquired renal injury as a mechanism of salt-sensitive hypertension","volume":"346","author":"Johnson","year":"2002","journal-title":"N Engl J Med"},{"key":"key-10.1136\/heartjnl-2012-302535-33","first-page":"F606","article-title":"Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all","volume":"286","author":"Rodriguez-Iturbe","year":"2004","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-34","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.semnephrol.2011.08.008","article-title":"Uric acid and hypertension","volume":"31","author":"Feig","year":"2011","journal-title":"Semin Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.HYP.0000085858.66548.59","article-title":"Hyperuricemia in childhood primary hypertension","volume":"42","author":"Feig","year":"2003","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-36","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2215\/CJN.11451210","article-title":"A randomized study of allopurinol on endothelial function and estimated glomerular filtration rate in asymptomatic hyperuricemic subjects with normal renal function","volume":"6","author":"Kanbay","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-37","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11255-007-9253-3","article-title":"Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions","volume":"39","author":"Kanbay","year":"2007","journal-title":"Int Urol Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-38","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.288.23.2981","article-title":"Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group","volume":"288","year":"2002","journal-title":"Jama"},{"key":"key-10.1136\/heartjnl-2012-302535-39","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/01.STR.0000221716.55088.d4","article-title":"Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study","volume":"37","author":"Bos","year":"2006","journal-title":"Stroke"},{"key":"key-10.1136\/heartjnl-2012-302535-40","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/art.24612","article-title":"Hyperuricemia and risk of stroke: a systematic review and meta-analysis","volume":"61","author":"Kim","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key-10.1136\/heartjnl-2012-302535-41","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.STR.29.3.635","article-title":"Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus","volume":"29","author":"Lehto","year":"1998","journal-title":"Stroke"},{"key":"key-10.1136\/heartjnl-2012-302535-42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1373\/clinchem.2007.094425","article-title":"Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men","volume":"54","author":"Strasak","year":"2008","journal-title":"Clin Chem"},{"key":"key-10.1136\/heartjnl-2012-302535-43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijcard.2009.01.010","article-title":"Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study","volume":"142","author":"Ekundayo","year":"2010","journal-title":"Int J Cardiol"},{"key":"key-10.1136\/heartjnl-2012-302535-44","first-page":"485","article-title":"The ALLHAT and the cardioprotection conferred by diuretics in hypertensive patients: a connection with uric acid?","volume":"16","author":"Reyes","year":"2002","journal-title":"Cardiovasc Drugs Ther"},{"key":"key-10.1136\/heartjnl-2012-302535-45","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/HYPERTENSIONAHA.111.181248","article-title":"Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial","volume":"58","author":"Ernst","year":"2011","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/01.HYP.0000203309.07140.d3","article-title":"Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure","volume":"47","author":"Ernst","year":"2006","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-47","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1097\/00004872-200018080-00021","article-title":"Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP)","volume":"18","author":"Franse","year":"2000","journal-title":"J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-48","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1523-1755.2004.00484.x","article-title":"The impact of serum uric acid on cardiovascular outcomes in the LIFE study","volume":"65","author":"Hoieggen","year":"2004","journal-title":"Kidney Int"},{"key":"key-10.1136\/heartjnl-2012-302535-49","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1681\/ASN.2007040416","article-title":"Thiazide diuretics exacerbate fructose-induced metabolic syndrome","volume":"18","author":"Reungjui","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-50","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1016\/S0021-9258(18)93017-6","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression","volume":"266","author":"Rao","year":"1991","journal-title":"J Biol Chem"},{"key":"key-10.1136\/heartjnl-2012-302535-51","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000087713","article-title":"Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter","volume":"25","author":"Kang","year":"2005","journal-title":"Am J Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-52","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1681\/ASN.2005050572","article-title":"Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells","volume":"16","author":"Kang","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-53","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ndt\/gfq635","article-title":"Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin","volume":"26","author":"Kanbay","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"key-10.1136\/heartjnl-2012-302535-54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11906-003-0029-6","article-title":"Hypertension and cognitive function: pathophysiologic effects of hypertension on the brain","volume":"5","author":"Manolio","year":"2003","journal-title":"Curr Hypertens Rep"},{"key":"key-10.1136\/heartjnl-2012-302535-55","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.STR.0000081983.34771.D2","article-title":"Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke","volume":"34","author":"Weir","year":"2003","journal-title":"Stroke"},{"key":"key-10.1136\/heartjnl-2012-302535-56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/dmrr.585","article-title":"Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes","volume":"22","author":"Newman","year":"2006","journal-title":"Diabetes Metab Res Rev"},{"key":"key-10.1136\/heartjnl-2012-302535-57","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1161\/01.STR.0000081984.07414.EF","article-title":"Editorial comment\u2013Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective","volume":"34","author":"Kanellis","year":"2003","journal-title":"Stroke"},{"key":"key-10.1136\/heartjnl-2012-302535-58","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/hs0402.105927","article-title":"Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke","volume":"33","author":"Chamorro","year":"2002","journal-title":"Stroke"},{"key":"key-10.1136\/heartjnl-2012-302535-59","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/oxfordjournals.eurheartj.a015352","article-title":"Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure","volume":"18","author":"Leyva","year":"1997","journal-title":"Eur Heart J"},{"key":"key-10.1136\/heartjnl-2012-302535-60","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1053\/euhj.1998.1188","article-title":"Uric acid in chronic heart failure: a marker of chronic inflammation","volume":"19","author":"Leyva","year":"1998","journal-title":"Eur Heart J"},{"key":"key-10.1136\/heartjnl-2012-302535-61","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.amjcard.2011.12.018","article-title":"Prognostic value of uric acid in patients with acute coronary syndromes","volume":"109","author":"Ndrepepa","year":"2012","journal-title":"Am J Cardiol"},{"key":"key-10.1136\/heartjnl-2012-302535-62","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2143\/AC.60.5.2004969","article-title":"Serum uric acid levels as a predictor of in-hospital death in patients hospitalized for decompensated heart failure","volume":"60","author":"Cengel","year":"2005","journal-title":"Acta cardiologica"},{"key":"key-10.1136\/heartjnl-2012-302535-63","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1253\/circj.70.1006","article-title":"Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure","volume":"70","author":"Sakai","year":"2006","journal-title":"Circ J"},{"key":"key-10.1136\/heartjnl-2012-302535-64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1751-7133.2011.00200.x","article-title":"Uric acid as a predictor of all-cause mortality in heart failure: a meta-analysis","volume":"17","author":"Tamariz","year":"2011","journal-title":"Congest Heart Fail"},{"key":"key-10.1136\/heartjnl-2012-302535-65","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2003.055913","article-title":"Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications","volume":"555","author":"Berry","year":"2004","journal-title":"J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-66","doi-asserted-by":"crossref","first-page":"L830","DOI":"10.1152\/ajplung.00007.2008","article-title":"Xanthine oxidoreductase in respiratory and cardiovascular disorders","volume":"294","author":"Boueiz","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM196609012750902","article-title":"Hyperuricemia in primary and renal hypertension","volume":"275","author":"Cannon","year":"1966","journal-title":"N Engl J Med"},{"key":"key-10.1136\/heartjnl-2012-302535-68","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.CIR.0000066420.36123.35","article-title":"Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology","volume":"107","author":"Hare","year":"2003","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-69","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1161\/01.CIR.0000017502.58595.ED","article-title":"Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies","volume":"105","author":"Doehner","year":"2002","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-70","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.CIR.0000022140.61460.1D","article-title":"Allopurinol improves endothelial dysfunction in chronic heart failure","volume":"106","author":"Farquharson","year":"2002","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-71","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid","volume":"114","author":"George","year":"2006","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-72","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1161\/hc4501.098928","article-title":"Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy","volume":"104","author":"Cappola","year":"2001","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/01.RES.0000200181.59551.71","article-title":"Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy","volume":"98","author":"Minhas","year":"2006","journal-title":"Circulation research"},{"key":"key-10.1136\/heartjnl-2012-302535-74","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.jacc.2008.01.068","article-title":"Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study","volume":"51","author":"Hare","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"key-10.1136\/heartjnl-2012-302535-75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1751-7133.2011.00262.x","article-title":"Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition","volume":"18","author":"Harzand","year":"2012","journal-title":"Congest Heart Fail"},{"key":"key-10.1136\/heartjnl-2012-302535-76","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1001\/jama.283.18.2404","article-title":"Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971\u20131992. National Health and Nutrition Examination Survey","volume":"283","author":"Fang","year":"2000","journal-title":"Jama"},{"key":"key-10.1136\/heartjnl-2012-302535-77","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1161\/01.HYP.34.1.144","article-title":"Serum uric acid and cardiovascular events in successfully treated hypertensive patients","volume":"34","author":"Alderman","year":"1999","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-78","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study","volume":"131","author":"Culleton","year":"1999","journal-title":"Ann Intern Med"},{"key":"key-10.1136\/heartjnl-2012-302535-79","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/hrt.78.2.147","article-title":"Serum urate and the risk of major coronary heart disease events","volume":"78","author":"Wannamethee","year":"1997","journal-title":"Heart"},{"key":"key-10.1136\/heartjnl-2012-302535-80","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.pmed.0020076","article-title":"Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis","volume":"2","author":"Wheeler","year":"2005","journal-title":"PLoS Med"},{"key":"key-10.1136\/heartjnl-2012-302535-81","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","article-title":"Hyperuricemia and coronary heart disease: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"key-10.1136\/heartjnl-2012-302535-82","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/oxfordjournals.aje.a117479","article-title":"Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study","volume":"141","author":"Freedman","year":"1995","journal-title":"Am J Epidemiol"},{"key":"key-10.1136\/heartjnl-2012-302535-83","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archinte.1995.00430070036004","article-title":"Lifestyle and biologic factors associated with atherosclerotic disease in middle-aged men. 20-year findings from the Honolulu Heart Program","volume":"155","author":"Goldberg","year":"1995","journal-title":"Arch Intern Med"},{"key":"key-10.1136\/heartjnl-2012-302535-84","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00001648-199907000-00009","article-title":"Association of serum uric acid with all-cause and cardiovascular disease mortality and incident myocardial infarction in the MONICA Augsburg cohort. World Health Organization Monitoring Trends and Determinants in Cardiovascular Diseases","volume":"10","author":"Liese","year":"1999","journal-title":"Epidemiology"},{"key":"key-10.1136\/heartjnl-2012-302535-85","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.atherosclerosis.2005.01.018","article-title":"Hyperuricemia as a risk factor on cardiovascular events in Taiwan: the Chin-Shan Community Cardiovascular Cohort Study","volume":"183","author":"Chien","year":"2005","journal-title":"Atherosclerosis"},{"key":"key-10.1136\/heartjnl-2012-302535-86","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1291\/hypres.30.823","article-title":"Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki","volume":"30","author":"Baba","year":"2007","journal-title":"Hypertens Res"},{"key":"key-10.1136\/heartjnl-2012-302535-87","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/ATVBAHA.107.160184","article-title":"Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA\/KORA cohort study","volume":"28","author":"Meisinger","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key-10.1136\/heartjnl-2012-302535-88","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(10)60391-1","article-title":"Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial","volume":"375","author":"Noman","year":"2010","journal-title":"Lancet"},{"key":"key-10.1136\/heartjnl-2012-302535-89","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1161\/01.HYP.35.3.e10","article-title":"Much ado about nothing, or much to do about something? The continuing controversy over the role of uric acid in cardiovascular disease","volume":"35","author":"Johnson","year":"2000","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-90","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/10715769309147501","article-title":"Identification of products from oxidation of uric acid induced by hydroxyl radicals","volume":"18","author":"Hicks","year":"1993","journal-title":"Free Radic Res Commun"},{"key":"key-10.1136\/heartjnl-2012-302535-91","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/15257770802138558","article-title":"Uric acid: the oxidant-antioxidant paradox","volume":"27","author":"Sautin","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"key-10.1136\/heartjnl-2012-302535-92","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bcp.2005.05.009","article-title":"Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase","volume":"70","author":"Kuzkaya","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"key-10.1136\/heartjnl-2012-302535-93","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/15257770902736400","article-title":"Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress","volume":"28","author":"Gersch","year":"2009","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"key-10.1136\/heartjnl-2012-302535-94","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.abb.2003.10.011","article-title":"Triuret: a novel product of peroxynitrite-mediated oxidation of urate","volume":"423","author":"Robinson","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"key-10.1136\/heartjnl-2012-302535-95","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/15257770802257952","article-title":"Inactivation of nitric oxide by uric acid","volume":"27","author":"Gersch","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"key-10.1136\/heartjnl-2012-302535-96","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jchromb.2008.11.029","article-title":"Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry","volume":"877","author":"Kim","year":"2009","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key-10.1136\/heartjnl-2012-302535-97","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.freeradbiomed.2010.04.010","article-title":"Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry","volume":"49","author":"Imaram","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"key-10.1136\/heartjnl-2012-302535-98","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/HJH.0b013e328337da1d","article-title":"Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction","volume":"28","author":"Yu","year":"2010","journal-title":"J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-99","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/HJH.0b013e3282f240bf","article-title":"Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system","volume":"26","author":"Corry","year":"2008","journal-title":"J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-100","doi-asserted-by":"crossref","first-page":"C584","DOI":"10.1152\/ajpcell.00600.2006","article-title":"Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative\/nitrosative stress","volume":"293","author":"Sautin","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-101","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1681\/ASN.2008060576","article-title":"Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells","volume":"20","author":"Cirillo","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-102","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1745-7254.2008.00877.x","article-title":"Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells","volume":"29","author":"Chao","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"key-10.1136\/heartjnl-2012-302535-103","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000345509","article-title":"Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations","volume":"121","author":"Sanchez-Lozada","year":"2012","journal-title":"Nephron Exp Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-104","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0140-6736(62)90501-9","article-title":"Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals","volume":"280","author":"Faires","year":"1962","journal-title":"Lancet"},{"key":"key-10.1136\/heartjnl-2012-302535-105","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2","volume":"41","author":"Kanellis","year":"2003","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-106","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1097\/01.ASN.0000034910.58454.FD","article-title":"A role for uric acid in the progression of renal disease","volume":"13","author":"Kang","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-107","first-page":"F116","article-title":"Effect of elevated serum uric acid on cisplatin-induced acute renal failure","volume":"292","author":"Roncal","year":"2007","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-108","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/eurheartj\/ehi879","article-title":"Uric acid and inflammatory markers","volume":"27","author":"Ruggiero","year":"2006","journal-title":"Eur Heart J"},{"key":"key-10.1136\/heartjnl-2012-302535-109","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000320356","article-title":"Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats","volume":"48","author":"Schwartz","year":"2011","journal-title":"J Vasc Res"},{"key":"key-10.1136\/heartjnl-2012-302535-110","doi-asserted-by":"crossref","first-page":"C1183","DOI":"10.1152\/ajpcell.00075.2008","article-title":"Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells","volume":"295","author":"Zharikov","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-111","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int"},{"key":"key-10.1136\/heartjnl-2012-302535-112","first-page":"F625","article-title":"A causal role for uric acid in fructose-induced metabolic syndrome","volume":"290","author":"Nakagawa","year":"2006","journal-title":"Am J Physiol"},{"key":"key-10.1136\/heartjnl-2012-302535-113","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/ajh.2009.109","article-title":"Hyperuricemia, Oxidative Stress, and Carotid Artery Tone in Experimental Renal Insufficiency","volume":"22","author":"Kurra","year":"2009","journal-title":"Am J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-114","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/01.HYP.35.3.746","article-title":"Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension","volume":"35","author":"Butler","year":"2000","journal-title":"Hypertension"},{"key":"key-10.1136\/heartjnl-2012-302535-115","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.CIR.0000046448.26751.58","article-title":"Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers","volume":"107","author":"Guthikonda","year":"2003","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-116","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.amjcard.2004.06.032","article-title":"Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk","volume":"94","author":"Mercuro","year":"2004","journal-title":"Am J Cardiol"},{"key":"key-10.1136\/heartjnl-2012-302535-117","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1183\/09031936.06.00101005","article-title":"Allopurinol improves endothelial function in sleep apnoea: a randomised controlled study","volume":"27","author":"El Solh","year":"2006","journal-title":"Eur Respir J"},{"key":"key-10.1136\/heartjnl-2012-302535-118","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/08037051.2010.538977","article-title":"Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients","volume":"20","author":"Dogan","year":"2011","journal-title":"Blood Press"},{"key":"key-10.1136\/heartjnl-2012-302535-119","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00392-007-0636-3","article-title":"Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome","volume":"97","author":"Yiginer","year":"2008","journal-title":"Clin Res Cardiol"},{"key":"key-10.1136\/heartjnl-2012-302535-120","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2215\/CJN.11451210","article-title":"A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function","volume":"6","author":"Kanbay","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07435800.2011.566235","article-title":"Effect of the treatment with allopurinol on the endothelial function in patients with hyperuricemia","volume":"37","author":"Melendez-Ramirez","year":"2012","journal-title":"Endocr Res"},{"key":"key-10.1136\/heartjnl-2012-302535-122","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5414\/CN107352","article-title":"Reduction of uric acid levels with allopurinol treatment improves endothelial function in patients with chronic kidney disease","volume":"77","author":"Yelken","year":"2012","journal-title":"Clin Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-123","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1681\/ASN.2010111185","article-title":"Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease","volume":"22","author":"Kao","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-124","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1097\/HJH.0b013e328303205d","article-title":"Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency","volume":"26","author":"Eraranta","year":"2008","journal-title":"J Hypertens"},{"key":"key-10.1136\/heartjnl-2012-302535-125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1532-5415.1978.tb02396.x","article-title":"Serum uric acid and the renin-angiotensin system in hypertension","volume":"26","author":"Saito","year":"1978","journal-title":"J Am Geriatr Soc"},{"key":"key-10.1136\/heartjnl-2012-302535-126","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0272-6386(85)80146-3","article-title":"The adolescent with essential hypertension","volume":"6","author":"Gruskin","year":"1985","journal-title":"Am J Kidney Dis"},{"key":"key-10.1136\/heartjnl-2012-302535-127","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/cs0490613","article-title":"Plasma uric acid concentration related to the urinary excretion of aldosterone and of electrolytes in normal subjects","volume":"49","author":"Ramsay","year":"1975","journal-title":"Clin Sci"},{"key":"key-10.1136\/heartjnl-2012-302535-128","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1681\/ASN.V1271448","article-title":"Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function","volume":"12","author":"Kang","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"key-10.1136\/heartjnl-2012-302535-129","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1523-1755.2004.00909.x","article-title":"Uric acid and the state of the intrarenal renin-angiotensin system in humans","volume":"66","author":"Perlstein","year":"2004","journal-title":"Kidney Int"},{"key":"key-10.1136\/heartjnl-2012-302535-130","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"key-10.1136\/heartjnl-2012-302535-131","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.4049\/jimmunol.176.7.3905","article-title":"Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model","volume":"176","author":"Shi","year":"2006","journal-title":"J Immunol"},{"key":"key-10.1136\/heartjnl-2012-302535-132","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0167-5699(90)90050-J","article-title":"Heat shock proteins and the immune response","volume":"11","author":"Kaufmann","year":"1990","journal-title":"Immunol Today"},{"key":"key-10.1136\/heartjnl-2012-302535-133","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.CIR.99.7.934","article-title":"Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart","volume":"99","author":"Nishizawa","year":"1999","journal-title":"Circulation"},{"key":"key-10.1136\/heartjnl-2012-302535-134","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.2337\/dc09-0288","article-title":"Association between serum uric acid and development of type 2 diabetes","volume":"32","author":"Kodama","year":"2009","journal-title":"Diabetes Care"},{"key":"key-10.1136\/heartjnl-2012-302535-135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/er.2008-0033","article-title":"Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?","volume":"30","author":"Johnson","year":"2009","journal-title":"Endocr Rev"},{"key":"key-10.1136\/heartjnl-2012-302535-136","doi-asserted-by":"crossref","DOI":"10.1186\/2001-1326-1-16","article-title":"Contribution of uric acid to cancer risk, recurrence and mortality","author":"Fini","year":"2012","journal-title":"Clin Transl Med"},{"key":"key-10.1136\/heartjnl-2012-302535-137","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/CS20030149","article-title":"Uric acid reduces exercise-induced oxidative stress in healthy adults","volume":"105","author":"Waring","year":"2003","journal-title":"Clin Sci (Lond)"},{"key":"key-10.1136\/heartjnl-2012-302535-138","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.2337\/db06-0283","article-title":"Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers","volume":"55","author":"Waring","year":"2006","journal-title":"Diabetes"},{"key":"key-10.1136\/heartjnl-2012-302535-139","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCGENETICS.109.934455","article-title":"Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors","volume":"3","author":"Yang","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"key-10.1136\/heartjnl-2012-302535-140","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1371\/journal.pmed.0050197","article-title":"SLC2A9 is a high-capacity urate transporter in humans","volume":"5","author":"Caulfield","year":"2008","journal-title":"PLoS Med"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2012-302535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:36:03Z","timestamp":1714869363000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2012-302535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,23]]},"references-count":140,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,6,1]]}},"alternative-id":["10.1136\/heartjnl-2012-302535"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2012-302535","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,23]]}}}