{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:24:02Z","timestamp":1789752242001,"version":"4.0.1"},"reference-count":30,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2012,12,10]]},"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined cognitive function in older hospitalised patients with chronic atrial fibrillation (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective substudy of a multicentre randomised trial of an AF-specific disease management intervention (the Standard versus Atrial Fibrillation spEcific managmenT studY; SAFETY).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three tertiary referral hospitals within Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      A total of 260 patients with chronic AF: mean age 72\u00b111\u2005years, 53% men, mean CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      -VASc score 4\u00b12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Cognitive function was assessed at baseline (during inpatient stay) using the Montreal Cognitive Assessment (MoCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The extent of mild cognitive impairment (MCI\u2014defined as a MoCA score &lt;26) in AF patients and identification of independent predictors of MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 169 patients (65%, 95% CI 59% to 71%) were found to have MCI at baseline (mean MoCA score 21\u00b13). Multiple deficits in cognitive domains were identified, most notably in executive functioning, visuospatial abilities and short-term memory. Predictors of MCI (age and sex-adjusted) were lower education level (technical\/trade school level OR 6.00, 95% CI 2.07 to 17.42; &lt;8\u2005years school education OR 5.29, 95% CI 1.95 to 14.36 vs 8\u201313\u2005years), higher CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      -VASc score (OR 1.46, 95% CI 1.23 to 1.74) and prescribed digoxin (OR 2.19, 95% CI 1.17 to 4.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MCI is highly prevalent amongst typically older high-risk patients hospitalised with AF. Routine assessment of cognitive function with adjustment of clinical management is indicated for this patient group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-303182","type":"journal-article","created":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T20:39:31Z","timestamp":1358023171000},"page":"542-547","source":"Crossref","is-referenced-by-count":64,"title":["Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?"],"prefix":"10.1136","volume":"99","author":[{"given":"Jocasta","family":"Ball","sequence":"first","affiliation":[{"name":"National Health and Medical Research Council of Australia Centre of Research Excellence to Reduce Inequality in Heart Disease\/Preventative Health, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda Jane","family":"Carrington","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council of Australia Centre of Research Excellence to Reduce Inequality in Heart Disease\/Preventative Health, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Stewart","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council of Australia Centre of Research Excellence to Reduce Inequality in Heart Disease\/Preventative Health, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia"},{"name":"Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SAFETY investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,1,12]]},"reference":[{"key":"2025092000423670000_99.8.542.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"2025092000423670000_99.8.542.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"2025092000423670000_99.8.542.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"2025092000423670000_99.8.542.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072767.89944.6E"},{"key":"2025092000423670000_99.8.542.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.9.969"},{"key":"2025092000423670000_99.8.542.6","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301682"},{"key":"2025092000423670000_99.8.542.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.2.316"},{"key":"2025092000423670000_99.8.542.8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn341"},{"key":"2025092000423670000_99.8.542.9","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.STR.29.9.1816","article-title":"Atrial fibrillation is an independent determinant of low cognitive function: a cross-sectional study in elderly men","volume":"29","author":"Kilander","year":"1998","journal-title":"Stroke"},{"key":"2025092000423670000_99.8.542.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2178"},{"key":"2025092000423670000_99.8.542.11","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390220082016"},{"key":"2025092000423670000_99.8.542.12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0404.1993.tb05509.x","article-title":"Relationship between vascular factors and white matter low attenuation of the brain","volume":"87","author":"Tarvonen","year":"1993","journal-title":"Acta Neurol Scand"},{"key":"2025092000423670000_99.8.542.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0910237"},{"key":"2025092000423670000_99.8.542.14","doi-asserted-by":"publisher","DOI":"10.1159\/000082351"},{"key":"2025092000423670000_99.8.542.15","unstructured":"Carrington MJ Ball J Horowitz JD . 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