{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:55:30Z","timestamp":1785610530493,"version":"3.56.0"},"reference-count":49,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2013,1,31]]},"published-print":{"date-parts":[[2013,5,1]]},"abstract":"\n Background<\/jats:title>\n Overlapping first generation sirolimus- and paclitaxel-eluting stents are associated with persistent inflammation, fibrin deposition and delayed endothelialisation in preclinical models, and adverse angiographic and clinical outcomes\u2014including death and myocardial infarction (MI)\u2014in clinical studies.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To establish as to whether there are any safety concerns with newer generation drug-eluting stents (DES).<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Propensity score adjustment of baseline anatomical and clinical characteristics were used to compare clinical outcomes (Kaplan\u2013Meier estimates) between patients implanted with overlapping DES (Resolute zotarolimus-eluting stent (R-ZES) or R-ZES\/other DES) against no overlapping DES. Additionally, angiographic outcomes for overlapping R-ZES and everolimus-eluting stents were evaluated in the randomised RESOLUTE All-Comers Trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Patient level data from five controlled studies of the RESOLUTE Global Clinical Program evaluating the R-ZES were pooled. Enrolment criteria were generally unrestrictive.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n 5130 patients.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n 2-year clinical outcomes and 13-month angiographic outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 644 of 5130 patients (12.6%) in the RESOLUTE Global Clinical Program underwent overlapping DES implantation. Implantation of overlapping DES was associated with an increased frequency of MI and more complex\/calcified lesion types at baseline. Adjusted in-hospital, 30-day and 2-year clinical outcomes indicated comparable cardiac death (2-year overlap vs non-overlap: 3.0% vs 2.1%, p=0.36), major adverse cardiac events (13.3% vs 10.7%, p=0.19), target-vessel MI (3.9% vs 3.4%, p=0.40), clinically driven target vessel revascularisation (7.7% vs 6.5%, p=0.32), and definite\/probable stent thrombosis (1.4% vs 0.9%, p=0.28). 13-month adjusted angiographic outcomes were comparable between overlapping and non-overlapping DES.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Overlapping newer generation DES are safe and effective, with comparable angiographic and clinical outcomes\u2014including repeat revascularisation\u2014to non-overlapping DES.<\/jats:p>\n <\/jats:sec>\n \n ClinicalTrials.gov Identifiers<\/jats:title>\n NCT00248079; NCT00617084<\/jats:ext-link>; NCT00726453<\/jats:ext-link>; NCT00752128<\/jats:ext-link>; NCT00927940<\/jats:ext-link>.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/heartjnl-2012-303368","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T21:39:53Z","timestamp":1362605993000},"page":"626-633","source":"Crossref","is-referenced-by-count":31,"title":["Impact of overlapping newer generation drug-eluting stents on clinical and angiographic outcomes: pooled analysis of five trials from the international Global RESOLUTE Program"],"prefix":"10.1136","volume":"99","clinical-trial-number":[{"clinical-trial-number":"nct00617084","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00726453","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00752128","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00927940","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Vasim","family":"Farooq","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Erasmus University Medical Centre, Rotterdam, The 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmund","family":"Silber","sequence":"additional","affiliation":[{"name":"Kardiologische Praxis und Praxisklinik, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Widimsky","sequence":"additional","affiliation":[{"name":"Cardiocenter Kralovske Vinohrady, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York-Presbyterian Hospital, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"University Hospital Foundation, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Meredith","sequence":"additional","affiliation":[{"name":"Monash Heart and Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Negoita","sequence":"additional","affiliation":[{"name":"Medtronic, Santa Rosa, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Medtronic, Santa Rosa, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Joseph","family":"Neumann","sequence":"additional","affiliation":[{"name":"Heart Center Bad Krozingen, Bad Krozingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C","family":"Yeung","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine, Palo Alto, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M","family":"Garcia-Garcia","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Erasmus 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