{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:28:08Z","timestamp":1792006088507,"version":"4.4.0"},"reference-count":21,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2013,10,8]]},"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the relationship between inhospital bleeding as defined by Bleeding Academic Research Consortium (BARC) consensus classification and short-term and long-term mortality in unselected patients admitted for primary percutaneous coronary intervention (PCI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed data of all consecutive patients with ST segment elevation myocardial infarction (STEMI) admitted for primary PCI, enrolled in a prospective registry of a high volume centre. The BARC-defined bleeding events were reconstructed from the detailed, prospectively collected clinical data. The primary outcome was mortality at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 1808 patients with STEMI admitted for primary PCI, 115 (6.4%) experienced a BARC type \u22652 bleeding. As the BARC bleeding severity worsened, there was a gradient of increasing rates of 1-year death. The 1-year mortality rate increased from 11.5% with BARC 0+1 type to 43.5% with BARC type 3b bleeding. After multivariable adjustment for demographic and clinical characteristics of patients, the independent predictors of 1-year death were BARC type 3a (HR 1.99; 95% CI 1.16 to 3.40, p=0.012) and BARC type 3b bleeding (HR 3.22; 95% CI 1.67 to 6.20, p&lt;0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The present study demonstrated that bleeding events defined according to the BARC classification hierarchically correlate with 1-year mortality after admission for primary PCI. The strongest predictor of 1-year mortality is the BARC type 3b bleeding.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2013-304564","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T03:50:38Z","timestamp":1383277838000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic implications of bleeding measured by Bleeding Academic Research Consortium (BARC) categorisation in patients undergoing primary percutaneous coronary intervention"],"prefix":"10.1136","volume":"100","author":[{"given":"Dragan M","family":"Matic","sequence":"first","affiliation":[{"name":"Emergency Department, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan G","family":"Milasinovic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milika R","family":"Asanin","sequence":"additional","affiliation":[{"name":"Emergency Department, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor B","family":"Mrdovic","sequence":"additional","affiliation":[{"name":"Emergency Department, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena M","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola I","family":"Kocev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija M","family":"Marjanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebojsa M","family":"Antonijevic","sequence":"additional","affiliation":[{"name":"Emergency Department, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladan D","family":"Vukcevic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija Z","family":"Savic","sequence":"additional","affiliation":[{"name":"Emergency Department, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milorad N","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatko H","family":"Mehmedbegovic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir M","family":"Dedovic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran R","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Catheterization Laboratories, Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"2025092014292191000_100.2.146.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00972-X"},{"key":"2025092014292191000_100.2.146.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612812"},{"key":"2025092014292191000_100.2.146.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.027"},{"key":"2025092014292191000_100.2.146.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.040"},{"key":"2025092014292191000_100.2.146.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.12.017"},{"key":"2025092014292191000_100.2.146.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61484-7"},{"key":"2025092014292191000_100.2.146.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.021"},{"key":"2025092014292191000_100.2.146.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.04.009"},{"key":"2025092014292191000_100.2.146.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"2025092014292191000_100.2.146.10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.060871"},{"key":"2025092014292191000_100.2.146.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00618-8"},{"key":"2025092014292191000_100.2.146.12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"2025092014292191000_100.2.146.13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017635.82128.8C"},{"key":"2025092014292191000_100.2.146.14","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"2025092014292191000_100.2.146.15","doi-asserted-by":"crossref","unstructured":"Therneau 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Modeling survival data: extending the cox model. 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