{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:29:47Z","timestamp":1790101787687,"version":"4.0.1"},"reference-count":35,"publisher":"BMJ","issue":"17","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2014,4,11]]},"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation &gt;40\u2005mm and long-term outcome in adults who underwent ASO in childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All 116 ASO patients operated in a tertiary referral centre and born before 1995 were included. Of these, 83 (72%) survived to adulthood (&gt;17\u2005years) and six were lost to follow-up. Neo-aortic measurements performed in adulthood were collected from available echocardiographic, cardiovascular magnetic resonance and CT images. The time trend was analysed using a mixed model, adjusted for imaging modality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Clinical data with at least one measurement of the neo-aortic diameter were available in 77 (93%) adult patients and serial measurements in 65 (78%). At baseline (median age 18.1\u2005years), mean neo-aortic diameter was 36\u00b15\u2005mm. Mean neo-aortic growth was 0.31\u2005mm\/year (p&lt;0.001 compared with normal value 0.08\u2005mm\/year) and was linear over time. Freedom from neo-aortic dilation beyond a diameter of 40\u2005mm was 23% at 28\u2005years of age. During a mean clinical follow-up in adulthood of 7.2\u2005years (IQR 4.0 to 10.1), 3 (4%) patients underwent neo-aortic replacement. No other neo-aortic complications occurred.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In early adulthood, neo-aortic growth was on average linear and did not stabilise over time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2014-305702","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T04:10:56Z","timestamp":1400299856000},"page":"1360-1365","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Persistent neo-aortic growth during adulthood in patients after an arterial switch operation"],"prefix":"10.1136","volume":"100","author":[{"given":"Teun","family":"van der Bom","sequence":"first","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"The Netherlands Heart Institute, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel L F","family":"van der Palen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berto J","family":"Bouma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert W","family":"Vliegen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thelma C","family":"Konings","sequence":"additional","affiliation":[{"name":"Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aeilko H","family":"Zwinderman","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico A","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave R","family":"Koolbergen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J M","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands"},{"name":"The Netherlands Heart Institute, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"2025092003512365000_100.17.1360.1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0022-5223(19)40063-9","article-title":"Anatomic correction of transposition of the great vessels","volume":"72","author":"Jatene","year":"1976","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025092003512365000_100.17.1360.2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105182"},{"key":"2025092003512365000_100.17.1360.3","doi-asserted-by":"crossref","unstructured":"Junge C Westhoff-Bleck M Schoof S . 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