{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:58:02Z","timestamp":1781805482021,"version":"3.54.5"},"reference-count":28,"publisher":"BMJ","issue":"18","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2015,5,26]]},"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To study the relationship between acute air pollution exposure and cardiovascular events during labour\/delivery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Consortium on Safe Labor (2002\u20132008), an observational US cohort with 223\u2005502 singleton deliveries provided electronic medical records. Air pollution exposure was estimated by modified Community Multiscale Air Quality models. Cardiovascular events (cardiac failure\/arrest, stroke, myocardial infarcts and other events) were recorded in the hospital discharge records for 687 pregnancies (0.3%). Logistic regression with generalised estimating equations estimated the relationship between cardiovascular events and daily air pollutant levels for delivery day and the 7\u2005days preceding delivery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Increased odds of cardiovascular events were observed for each IQR increase in exposure to nitric oxides at 5 and 6\u2005days prior to delivery (OR=1.17, 99% CI 1.04 to 1.30 and OR=1.15, 1.03 to 1.28, respectively). High exposure to toxic air pollution species such as ethylbenzene (OR=1.50, 1.08 to 2.09), m-xylene (OR=1.54, 1.11 to 2.13), o-xylene (OR=1.51, 1.09 to 2.09), p-xylene (OR=1.43, 1.03 to 1.99) and toluene (OR=1.42, 1.02 to 1.97) at 5\u2005days prior to delivery were also associated with cardiovascular events. Decreased odds of events were observed with exposure to ozone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Air pollution in the days prior to delivery, especially nitrogen oxides and some toxic air pollution species, was associated with increased risk of cardiovascular events during the labour\/delivery admission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2014-307366","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T21:52:14Z","timestamp":1435096334000},"page":"1491-1498","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Acute and recent air pollution exposure and cardiovascular events at labour and delivery"],"prefix":"10.1136","volume":"101","author":[{"given":"Tuija","family":"M\u00e4nnist\u00f6","sequence":"first","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA"},{"name":"Northern Finland Laboratory Centre NordLab, Oulu, Finland"},{"name":"Department of Clinical Chemistry, University of Oulu, Oulu, Finland"},{"name":"Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland"},{"name":"Department of Chronic Disease Prevention, National Institute for Health and Welfare, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mendola","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Laughon","family":"Grantz","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Leishear","sequence":"additional","affiliation":[{"name":"Glotech Inc., Rockville, Maryland, USA"},{"name":"US Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Sherman","sequence":"additional","affiliation":[{"name":"The EMMES Corporation, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ying","sequence":"additional","affiliation":[{"name":"Zachry Department of Civil Engineering, Texas A&M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danping","family":"Liu","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"key":"2025092014573045000_101.18.1491.1","unstructured":"Ostro B . 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