{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:10:48Z","timestamp":1793311848230,"version":"4.5.0"},"reference-count":30,"publisher":"BMJ","issue":"24","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2016,6,29]]},"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The evidence for cardiac rehabilitation after valve surgery remains sparse. Current recommendations are therefore based on patients with ischaemic heart disease. The aim of this randomised clinical trial was to assess the effects of cardiac rehabilitation versus usual care after heart valve surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The trial was an investigator-initiated, randomised superiority trial (The CopenHeart<jats:sub>VR<\/jats:sub> trial, VR; valve replacement or repair). We randomised 147 patients after heart valve surgery 1:1 to 12\u2005weeks of cardiac rehabilitation consisting of physical exercise and monthly psycho-educational consultations (intervention) versus usual care without structured physical exercise or psycho-educational consultations (control). Primary outcome was physical capacity measured by VO<jats:sub>2<\/jats:sub> peak and secondary outcome was self-reported mental health measured by Short Form-36.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>76% were men, mean age 62\u2005years, with aortic (62%), mitral (36%) or tricuspid\/pulmonary valve surgery (2%). Cardiac rehabilitation compared with control had a beneficial effect on VO<jats:sub>2<\/jats:sub> peak at 4\u2005months (24.8\u2005mL\/kg\/min vs 22.5\u2005mL\/kg\/min, p=0.045) but did not affect Short Form-36 Mental Component Scale at 6\u2005months (53.7 vs 55.2 points, p=0.40) or the exploratory physical and mental outcomes. Cardiac rehabilitation increased the occurrence of self-reported non-serious adverse events (11\/72 vs 3\/75, p=0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cardiac rehabilitation after heart valve surgery significantly improves VO<jats:sub>2<\/jats:sub> peak at 4\u2005months but has no effect on mental health and other measures of exercise capacity and self-reported outcomes. Further research is needed to justify cardiac rehabilitation in this patient group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>NCT01558765, Results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-309414","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T23:04:02Z","timestamp":1470351842000},"page":"1995-2003","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Cardiac rehabilitation increases physical capacity but not mental health after heart valve surgery: a randomised clinical trial"],"prefix":"10.1136","volume":"102","clinical-trial-number":[{"clinical-trial-number":"nct01558765","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Kirstine L","family":"Sibilitz","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina K","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Department of Cardiology, Gentofte Hospital, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine B","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Department of Cardiology, Gentofte Hospital, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Stelling","family":"Risom","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Bachelor's Degree Programme in Nursing, Metropolitan University College, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lau C","family":"Thygesen","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Faculty of Health and Technology, Bachelor's Degree Programme in Physiotherapy, Department of Rehabilitation and Nutrition, Metropolitan University College, Copenhagen, Denmark"},{"name":"CopenRehab, Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina B","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Zealand University Hospital, Department of Cardiology, K\u00f8gevej 7-13, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille Palm","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Department 7812, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Lindschou","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Department 7812, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Schmid","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Tiefenau Hospital and University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of 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