{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:01Z","timestamp":1790357581127,"version":"4.1.0"},"reference-count":23,"publisher":"BMJ","issue":"23","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2016,6,10]]},"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Structural valve degeneration (SVD) leads to the failure of aortic valve bioprostheses. It is suspected that lipid-derived factors could play a role in SVD. We hypothesised that oxidised low-density lipoprotein (OxLDL), OxLDL\/LDL, OxLDL\/high-density lipoprotein (OxLDL\/HDL) and proprotein convertase subtilisin\/kexin 9 (PCSK9) may be associated with SVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included 199 patients who underwent an aortic valve replacement with a bioprosthesis and had an echocardiography follow-up to evaluate the function of the prosthesis. SVD was defined as an increase in mean transprosthetic gradient (\u226510\u2005mm\u2005Hg) or a worsening of transprosthetic regurgitation (\u22651\/3) during the follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After a mean follow-up of 8\u00b13.5\u2005years, 41(21%) patients developed SVD. The univariate predictors of SVD were LDL (p=0.03), apolipoprotein B (p=0.01), OxLDL (p=0.02), OxLDL\/HDL (p=0.009) and LDL associated with small, dense particles (LDL-C<jats:sub>&lt;255\u00c5<\/jats:sub>) (p=0.02). In a model adjusted for covariates, only OxLDL\/HDL (OR 1.49, 95%CI 1.08 to 2.07 per 10 units, p=0.01) remained associated with SVD. There was a significant interaction between OxLDL\/HDL and PCSK9 on SVD (p=0.05). After adjustment, compared with patients with low OxLDL\/HDL (median, &lt;25.4) and low PCSK9 (median, &lt;298\u2005ng\/mL) (referent), patients with both an elevated OxLDL\/HDL ratio and PCSK9 had a higher risk of SVD (OR 2.93, 95% CI 1.02 to 9.29, p=0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>OxLDL\/HDL ratio is independently associated with SVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-309541","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T21:58:45Z","timestamp":1467669525000},"page":"1915-1921","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration"],"prefix":"10.1136","volume":"102","author":[{"given":"Mohamed Jalloul","family":"Nsaibia","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute\/Research Center, Laval University, Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ablajan","family":"Mahmut","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute\/Research Center, Laval University, Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellaziz","family":"Dahou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihab","family":"Bouchareb","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute\/Research Center, Laval University, Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Chlo\u00e9","family":"Boulanger","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute\/Research Center, Laval University, Quebec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Despr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet J","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Larose","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laval University, Qu\u00e9bec, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute\/Research Center, Laval University, Quebec, Quebec, 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