{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:33:14Z","timestamp":1760747594977,"version":"build-2065373602"},"reference-count":30,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2016,7,19]]},"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>72 healthy recreational runners (54% male\/46% female) recruited by age (group 1 (18\u201320\u2005years old, N=19); group 2 (45\u201350\u2005years old, N=27); group 3 (70\u201375\u2005years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10\u2005km running race.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3\u0394: 16\u00b122\u2005pg\/mL, p=0.001), hs-CRP increased only among younger runners (group 1\u0394: 1.5\u00b12.7\u2005mg\/L, p=0.03) and cTnI increased in both younger (group 1\u0394: 0.01\u00b10.02\u2005ng\/mL, p=0.028) and older (group 3\u0394: 0.01\u00b10.01\u2005ng\/mL, p=0.007) runners, but not middle aged runners (group 2\u0394: 0.00\u00b10.00\u2005ng\/mL, p=0.57).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-310059","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T22:19:23Z","timestamp":1471385963000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of moderate distance recreational running and ageing on cardiac physiology"],"prefix":"10.1136","volume":"103","author":[{"given":"Jonathan H","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"},{"name":"Atlanta Track Club, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-An","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Hedley","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"MacNamara","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mosaab","family":"Awad","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Healy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Aida","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc-Anh","family":"Le","sequence":"additional","affiliation":[{"name":"Biomarker Core Laboratory, Veterans\u2019 Affairs Medical Center, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"},{"name":"Biomarker Core Laboratory, Veterans\u2019 Affairs Medical Center, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"White","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence S","family":"Sperling","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Joseph S","family":"Wilson","sequence":"additional","affiliation":[{"name":"Atlanta Track Club, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron L","family":"Baggish","sequence":"additional","affiliation":[{"name":"Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"unstructured":"Lamppa R . 2015 state of the sport-U.S. race trends. 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