{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T03:53:59Z","timestamp":1763092439973,"version":"build-2065373602"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Clinical introduction<\/jats:title>\n                  <jats:p>A 16-day-old male neonate weighing 3.4\u2005kg presented with severe heart failure. His heart rate was 190\/min, normal sinus rhythm, blood pressure was 55\/30\u2005mm\u2005Hg and respiratory rate was 65\/min. Transthoracic echocardiography and cardiac MRI showed multiple intracardiac masses; the largest was filling most of the left ventricular cavity (figure 1A) (see online supplementary video 1 and figure S1), measuring around 2.8\u2005cm\u00d71.8\u2005cm and arising from the apical septum. Left ventricular function was moderately impaired with an ejection fraction of 40%. Due to accelerated haemodynamic instability, the mass was excised surgically. Through left ventriculotomy, a large mass could be identified which was attached with a pedicle to the apical septum. This mass was excised with its pedicle.<\/jats:p>\n                  <jats:p>During early postoperative course, the patient developed subdural and intraventricular haemorrhage, necessitating insertion of a ventriculoperitoneal shunt. MRI of the brain showed dark-signalled subependymal nodules and multiple cortical patches of high T2 signals (see online supplementary figure S2). The patient had no neurological sequelae and was discharged home.<\/jats:p>\n                  <jats:p>The patient was discharged home with no neurological sequelae. During the 2-year follow-up period, serial echocardiograms showed regression of the rest of the cardiac tumours and improvement of cardiac functions (see online supplementary figure S3). However, fibrous plaques were observed on the child's forehead.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Question<\/jats:title>\n                  <jats:p>What is the most likely diagnosis?\n<jats:list list-type=\"alpha-upper\">\n                        <jats:list-item>\n                           <jats:p>Hibernoma<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                           <jats:p>Fibroma<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                           <jats:p>Rhabdomyoma<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                           <jats:p>Rhabdomyosarcoma<\/jats:p>\n                        <\/jats:list-item>\n                     <\/jats:list>\n                  <\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-310251","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T22:59:13Z","timestamp":1474498753000},"page":"18-18","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Heart failure in a neonate with multiple cardiac masses"],"prefix":"10.1136","volume":"103","author":[{"given":"Emad","family":"Nasr","sequence":"first","affiliation":[{"name":"Aswan Heart Centre, Department of Cardiothoracic Surgery and PICU Department, Aswan, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Imperial College London, Harefield Heart Science Centre, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdi","family":"Yacoub","sequence":"additional","affiliation":[{"name":"Aswan Heart Centre, Department of Cardiothoracic Surgery and PICU Department, Aswan, Egypt"},{"name":"Imperial College London, Harefield Heart Science Centre, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"2025100706475689000_103.1.18.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.078576"},{"key":"2025100706475689000_103.1.18.2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s00246-003-0590-4","article-title":"Fetal and neonatal cardiac tumors","volume":"25","author":"Isaacs","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"2025100706475689000_103.1.18.3","unstructured":"Burke AP , Tazelaar H , Patel CR , et al . Benign tumors with myocyte differentiation. In: Travis W, ed . Tumours of the lung, thymus, pleura and heart. Lyon: Springer Verlag, 2004:254\u20139."},{"key":"2025100706475689000_103.1.18.4","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22202"},{"key":"2025100706475689000_103.1.18.5","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009067145"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2016-310251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:59:17Z","timestamp":1759845557000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2016-310251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,9]]},"published-print":{"date-parts":[[2017,1,1]]}},"alternative-id":["10.1136\/heartjnl-2016-310251"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2016-310251","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[2016,9,21]]}}}