{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:17:01Z","timestamp":1762867021905,"version":"build-2065373602"},"reference-count":14,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2016,12,7]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Percutaneous edge-to-edge mitral valve repair (PMVR) recently emerged as an effective treatment modality for patients with severe mitral regurgitation (MR). Length of postprocedural hospital stay may represent a modifiable cost associated with percutaneous treatment. We looked at feasibility, predictors and safety of early discharge (ED), defined as hospital discharge within 72\u2005hours, in patients undergoing PMVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients treated with MitraClip from October 2008 to December 2015 were analysed. Primary outcomes of interest were cardiovascular and non-cardiovascular mortality, rehospitalisation for heart failure and major adverse events at 30 days and 90\u2005days. A total of 269 patients were included. Of these, 115 patients were early discharged (ED group). Rates of ED increased from 25.9% for the biennium 2008\u20132009 to 59.1% in 2014\u20132015 (p&lt;0.001 for trend). In a penalised logistic regression model, male gender (OR=2.13, 95% CI 1.17 to 3.95) and procedural year (OR=2.13, 95% CI 1.51 to 3.11) were associated with higher probability of ED. Conversely, atrial fibrillation (OR=0.48, 95% CI 0.27 to 0.85), any Mitral Valve Academic Research Consortium bleeding (OR=0.07, 95% CI 0.01 to 0.60), log-transformed N-terminal pro-brain natriuretic peptide levels (OR=0.79, 95% CI 0.63 to 0.99) and postimplant MR grade (OR=0.60, 95% CI 0.37 to 0.94) conferred a lower likelihood of ED. In propensity score-weighted analyses, overall survival, freedom from heart failure and major adverse events at 30 days and 90\u2005days were not different in ED and non-ED groups (all weighted log-rank p value&gt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In selected patients undergoing PMVR, ED may be feasible and safe.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-310501","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T21:40:21Z","timestamp":1483998021000},"page":"931-936","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Feasibility and predictors of early discharge after percutaneous edge-to-edge mitral valve repair"],"prefix":"10.1136","volume":"103","author":[{"given":"Corrado","family":"Tamburino","sequence":"first","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Buccheri","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Popolo Rubbio","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Scandura","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mangiafico","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Imm\u00e9","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Caruso","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Scalia","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Condorelli","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Capranzano","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Capodanno","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Grasso","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"2025092022115925000_103.12.931.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"2025092022115925000_103.12.931.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.030"},{"key":"2025092022115925000_103.12.931.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.04.025"},{"key":"2025092022115925000_103.12.931.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.212"},{"key":"2025092022115925000_103.12.931.5","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.834823"},{"key":"2025092022115925000_103.12.931.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.01.300"},{"key":"2025092022115925000_103.12.931.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"2025092022115925000_103.12.931.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.024"},{"key":"2025092022115925000_103.12.931.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"2025092022115925000_103.12.931.10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/01823246-201223010-00002","article-title":"Early mobilization in the intensive care unit: a systematic review","volume":"23","author":"Adler","year":"2012","journal-title":"Cardiopulm Phys Ther J"},{"key":"2025092022115925000_103.12.931.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.054"},{"key":"2025092022115925000_103.12.931.12","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr029"},{"key":"2025092022115925000_103.12.931.13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.amjcard.2015.05.048","article-title":"Acute and midterm outcome after MitraClip therapy in patients with severe mitral regurgitation and left ventricular dysfunction","volume":"116","author":"Lesevic","year":"2015","journal-title":"Am J Cardiol"},{"key":"2025092022115925000_103.12.931.14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/joic.12179","article-title":"Effectiveness of MitraClip therapy in patients with refractory heart failure","volume":"28","author":"Adamo","year":"2015","journal-title":"J 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