{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:42:32Z","timestamp":1787899352972,"version":"build-2784847793"},"reference-count":17,"publisher":"BMJ","issue":"18","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,2,15]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The purpose of our study is (1) to characterise patients with congenital heart disease undergoing heart transplantation by adult cardiac surgeons in a large academic medical centre and (2) to describe successful outcomes associated with our multidisciplinary approach to the evaluation and treatment of adults with congenital heart disease (ACHD) undergoing orthotopic heart transplantation (OHT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Heart failure is the leading cause of death in patients with ACHD leading to increasing referrals for OHT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Penn Congenital Transplant Database comprises a cohort of patients with ACHD who underwent OHT between March 2010 and April 2016. We performed a retrospective cohort study of the 20 consecutive patients. Original cardiac diagnoses include single ventricle palliated with Fontan (n=8), dextro-transposition of the great arteries after atrial switch (n=4), tetralogy of Fallot (n=4), pulmonary atresia (n=1), Ebstein anomaly (n=1), unrepaired ventricular septal defect (n=1) and Noonan syndrome with coarctation of the aorta (n=1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight patients required pretransplant inotropes and two required pretransplant mechanical support. Nine patients underwent heart\u2013liver transplant and three underwent heart\u2013lung transplant. Three patients required postoperative mechanical circulatory support. Patients were followed for an average of 38 months as of April 2016, with 100% survival at 30 days and 1 year and 94% overall survival (19\/20 patients).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ACHD\u2013OHT patients require highly specialised, complex and multidisciplinary healthcare. The success of our programme is attributed to using team-based, patient-centred care including our multidisciplinary staff and specialists across programmes and departments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-310933","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T20:50:28Z","timestamp":1488574228000},"page":"1449-1454","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Successful cardiac transplantation outcomes in patients with adult congenital heart disease"],"prefix":"10.1136","volume":"103","author":[{"given":"Jonathan N","family":"Menachem","sequence":"first","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Golbus","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hornsby","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Atluri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fuller","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edo Y","family":"Birati","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee R","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce W","family":"Wald","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"2025092005420354000_103.18.1449.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.960260"},{"key":"2025092005420354000_103.18.1449.2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305667"},{"key":"2025092005420354000_103.18.1449.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq032"},{"key":"2025092005420354000_103.18.1449.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000204"},{"key":"2025092005420354000_103.18.1449.5","doi-asserted-by":"crossref","unstructured":"Ross HJ , Law Y , Book WM , et al . Transplantation and mechanical circulatory support in congenital heart disease: a scientific statement from the American heart association. Circulation 2016;133.doi:10.1161\/CIR.0000000000000353","DOI":"10.1161\/CIR.0000000000000353"},{"key":"2025092005420354000_103.18.1449.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.05.001"},{"key":"2025092005420354000_103.18.1449.7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.184713"},{"key":"2025092005420354000_103.18.1449.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.06.024"},{"key":"2025092005420354000_103.18.1449.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.09.008"},{"key":"2025092005420354000_103.18.1449.10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/ajt.13030","article-title":"The future direction of the adult heart allocation system in the United States","volume":"15","author":"Meyer","year":"2015","journal-title":"Am J Transplant"},{"key":"2025092005420354000_103.18.1449.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.001"},{"key":"2025092005420354000_103.18.1449.12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.776963"},{"key":"2025092005420354000_103.18.1449.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.020"},{"key":"2025092005420354000_103.18.1449.14","doi-asserted-by":"crossref","unstructured":"Gatzoulis MA , Webb GD , Daubeney PEF . Diagnosis and management of adult congenital heart disease. 2nd edn, 2011.","DOI":"10.1016\/B978-0-7020-3426-8.00001-0"},{"key":"2025092005420354000_103.18.1449.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.071"},{"key":"2025092005420354000_103.18.1449.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.015"},{"key":"2025092005420354000_103.18.1449.17","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.transproceed.2015.07.038","article-title":"Combined heart and liver transplantation: the Cedars-Sinai experience","volume":"47","author":"Reich","year":"2015","journal-title":"Transplant Proc"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2016-310933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:42:08Z","timestamp":1758372128000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2016-310933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":17,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2017,8,24]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1136\/heartjnl-2016-310933"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2016-310933","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]}}}