{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:39:42Z","timestamp":1794285582590,"version":"4.9.0"},"reference-count":22,"publisher":"BMJ","issue":"19","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,4,25]]},"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and outcomes of intracranial aneurysm (IA) in patients with bicuspid aortic valve (BAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of patients with BAV who underwent brain MR angiography at the Mayo Clinic from 1994 to 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 678 patients included in this study\u2014mean age 57\u00b113 years, men 480 (71%), mean follow-up 10\u00b13 years (5913 patient-years). Coarctation of aorta (COA) was present in 154 (23%) patients.<\/jats:p>\n                    <jats:p>There were 59 IAs identified in 52 of 678 patients (7.7%). IA was present in 20\/154 patients (12.9%) with COA and 32\/524 patients (5.7%) without COA (p&lt;0.001). For the patients without COA, female gender and right\u2013left cusp fusion were risks factors for IA in women after adjustment for all potential variables (HR 1.76, CI 1.31 to 2.68, p=0.03). There was no significant trend in the risk for IA across age tertiles: age \u226440 years versus 41\u201360 years (HR 1.19, p=0.34), and age 41\u201360\u2009years versus 61\u201380 years (HR 1.06, p=0.56).<\/jats:p>\n                    <jats:p>Among the 52 patients with IA, enlargement occurred in three patients (6%), rupture in two patients (4%) and four patients (8%) underwent coil embolisation. For the 626 patients without IA at baseline, no patient developed IA over 7\u00b12 years of imaging follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BAV is associated with a higher prevalence of IA compared to the general population, and this risk is higher in patients with COA, right\u2013left cusp fusion and female gender.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heartjnl-2016-311076","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T20:50:27Z","timestamp":1496955027000},"page":"1508-1514","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve"],"prefix":"10.1136","volume":"103","author":[{"given":"Alexander 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