{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:51:08Z","timestamp":1778799068161,"version":"3.51.4"},"reference-count":34,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,4,25]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In patients with bicuspid aortic valve (BAV), coronary anatomy is variable. High take-off coronary arteries have been described, but data are scarce, especially when associated with complex congenital heart disease (CHD). The purpose of this study was to describe coronary patterns in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 84 postmortem heart specimens with BAV and associated CHD, position and height of the coronary ostia were studied and related to BAV morphology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>High take-off right (RCA) and left coronary arteries (LCA) were observed in 23% and 37% of hearts, respectively, most frequently in hearts with hypoplastic left ventricle (HLV) and outflow tract anomalies. In HLV, high take-off was observed in 18\/40 (45%) more frequently of LCA (n=14) than RCA (n=6). In hearts with aortic hypoplasia, 8\/13 (62%) had high take-off LCA and 6\/13 (46%) high take-off RCA. High take-off was seen 19 times in 22 specimens with perimembranous ventricular septal defect (RCA 8, LCA 11). High take-off was associated with type 1A BAV (raphe between right and left coronary leaflets), more outspoken for the RCA. Separate ostia of left anterior descending coronary artery and left circumflex coronary artery were seen in four hearts (5%), not related to specific BAV morphology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>High take-off coronary arteries, especially the LCA, occur more frequently in BAV with associated CHD than reported in normal hearts and isolated BAV. Outflow tract defects and HLV are associated with type 1A BAV and high take-off coronary arteries. Although it is unclear whether these findings in infants with detrimental outcome can be related to surviving adults, clinical awareness of variations in coronary anatomy is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-311178","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T20:50:29Z","timestamp":1501188629000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Coronary anatomy in children with bicuspid aortic valves and associated congenital heart disease"],"prefix":"10.1136","volume":"104","author":[{"given":"Wilke M C","family":"Koenraadt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot M","family":"Bartelings","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"B\u00f6kenkamp","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana C","family":"Gittenberger-de Groot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco C","family":"DeRuiter","sequence":"additional","affiliation":[{"name":"Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J","family":"Schalij","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique RM","family":"Jongbloed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"2025092013213194000_104.5.385.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.132092"},{"key":"2025092013213194000_104.5.385.2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-015-0784-4"},{"key":"2025092013213194000_104.5.385.3","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301773"},{"key":"2025092013213194000_104.5.385.4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90985-2"},{"key":"2025092013213194000_104.5.385.5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308629"},{"key":"2025092013213194000_104.5.385.6","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810080311"},{"key":"2025092013213194000_104.5.385.7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90657-X"},{"key":"2025092013213194000_104.5.385.8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1997)10:5<297::AID-CA1>3.0.CO;2-O"},{"key":"2025092013213194000_104.5.385.9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1996)9:6<376::AID-CA3>3.0.CO;2-9"},{"key":"2025092013213194000_104.5.385.10","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0535-4"},{"key":"2025092013213194000_104.5.385.11","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/ca.22664","article-title":"The clinical anatomy of high take-off coronary arteries","volume":"29","author":"Loukas","year":"2016","journal-title":"Clin Anat"},{"key":"2025092013213194000_104.5.385.12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.2.142"},{"key":"2025092013213194000_104.5.385.13","first-page":"10","article-title":"Coronary artery anomalies in Turner syndrome","volume":"16","author":"Viuff","year":"2016","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2025092013213194000_104.5.385.14","first-page":"538","article-title":"Benign or malignant anomaly? 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