{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:39:57Z","timestamp":1787017197325,"version":"build-2736575974"},"reference-count":19,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,9,19]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence and factors associated with persistent pulmonary hypertension (PH) following transcatheter aortic valve replacement (TAVR) and its relationship with long-term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients who underwent TAVR from July 2011 through January 2016 were studied. The prevalence of baseline PH (mean pulmonary artery pressure \u226525\u2009mm Hg on right heart catheterisation) and the prevalence and the predictors of persistent\u2265moderate\u2009PH (pulmonary artery systolic pressure (PASP)&gt;45\u2009mm Hg on 1\u2009month post-TAVR transthoracic Doppler echocardiography) were collected. Cox models quantified the effect of persistent PH on subsequent mortality while adjusting for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 407 TAVR patients, 273 (67%) had PH at baseline. Of these, 102 (25%) had persistent\u2265moderate\u2009PH. Mortality at 2 years in patients with no baseline PH versus those with PH improvement (follow-up PASP\u226445\u2009mm Hg) versus those with persistent\u2265moderate\u2009PH was 15.4%, 16.6% and 31.3%, respectively (p=0.049). After adjusting for Society of Thoracic Surgeons Predicted Risk of Mortality and baseline right ventricular function (using tricuspid annular plane systolic excursion), persistent\u2265moderate\u2009PH remained associated with all-cause mortality (HR=1.82, 95%\u2009CI 1.06 to 3.12, p=0.03). Baseline characteristics associated with increased likelihood of persistent\u2265moderate\u2009PH were \u2265moderate\u2009tricuspid regurgitation, \u2265moderate\u2009mitral regurgitation, atrial fibrillation\/flutter, early (E) to late (A) ventricular filling velocities (E\/A ratio) and left atrial volume index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Persistency of even moderate or greater PH at 1\u2009month post-TAVR is common and associated with higher all-cause mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-311978","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T21:20:22Z","timestamp":1506979222000},"page":"821-827","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Outcomes of persistent pulmonary hypertension following transcatheter aortic valve replacement"],"prefix":"10.1136","volume":"104","author":[{"given":"Ahmad","family":"Masri","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Abdelkarim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Sharbaugh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Althouse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W","family":"Crock","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E","family":"Harinstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin E","family":"Kliner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forozan","family":"Navid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"Gleason","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-2074","authenticated-orcid":false,"given":"Jo\u00e3o L","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"2025092023395016000_104.10.821.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002358"},{"key":"2025092023395016000_104.10.821.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.031"},{"key":"2025092023395016000_104.10.821.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.08.019"},{"key":"2025092023395016000_104.10.821.4","doi-asserted-by":"crossref","unstructured":"Testa L , Latib A , De Marco F , et al . 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