{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:42:12Z","timestamp":1784227332686,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2017,9,4]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to identify positive and negative predictors of technical and clinical success for percutaneous coronary intervention (PCI) of chronic total occlusions (CTO).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a systematic review and meta-analysis of studies published between 2000 and 2016 analysing rates of CTO PCI success with respect to demographic and angiographic characteristics. Crude ORs and 95% CIs for each predictor were calculated using a random effects model. Predictors of technical and clinical success were assessed among 28 demographic and 31 angiographic variables. Clinical success was defined as technical success without major adverse cardiac events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 61 studies, totalling 69\u2009886 patients were included in this analysis. The major demographic characteristics associated with a 20% or greater reduction in the odds of technical and clinical success were a history of myocardial infarction, PCI, coronary artery bypass grafting, stroke\/transient ischaemic attack and peripheral vascular disease. Angiographic factors were generally stronger predictors of reduced technical and clinical success. Those associated with &gt;20% odds reduction included non-left anterior descending CTOs, multivessel disease, presence of bridging collaterals, moderate-to-severe calcification, &gt;45\u2009degree vessel bending, tortuous vessel, blunt stump and ostial lesions. Of these, novel predictors included prior PCI, prior stroke, peripheral vascular disease, presence of multivessel disease and bridging collaterals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The present study has identified strong negative predictors for clinical success for CTO PCI, which will aid in patient selection for this procedure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-311986","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T20:10:25Z","timestamp":1507320625000},"page":"517-524","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"104","author":[{"given":"Nelson","family":"Wang","sequence":"first","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"},{"name":"Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Fulcher","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"},{"name":"Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishan","family":"Abeysuriya","sequence":"additional","affiliation":[{"name":"University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Adams","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"},{"name":"Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Lal","sequence":"additional","affiliation":[{"name":"University of Sydney, Sydney, New South Wales, Australia"},{"name":"Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"2025101710373573000_104.6.517.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.12.065"},{"key":"2025101710373573000_104.6.517.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.007"},{"key":"2025101710373573000_104.6.517.3","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25264"},{"key":"2025101710373573000_104.6.517.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-009-0013-5"},{"key":"2025101710373573000_104.6.517.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.825760"},{"key":"2025101710373573000_104.6.517.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.10.011"},{"key":"2025101710373573000_104.6.517.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.033"},{"key":"2025101710373573000_104.6.517.8","first-page":"28","article-title":"Successful revascularization 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